دورية أكاديمية
Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips.
| العنوان: | Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. |
|---|---|
| المؤلفون: | Sedláková, Veronika1,2 (AUTHOR) veronika.sedlakova@mail.muni.cz, Kloučková, Michaela1 (AUTHOR), Garlíková, Zuzana1,3 (AUTHOR), Vašíčková, Kateřina1,3 (AUTHOR), Jaroš, Josef1,3 (AUTHOR), Kandra, Mário1,3 (AUTHOR), Kotasová, Hana1 (AUTHOR), Hampl, Aleš1,3 (AUTHOR) |
| المصدر: | Drug Discovery Today. Apr2019, Vol. 24 Issue 4, p971-982. 12p. |
| مصطلحات موضوعية: | *RESPIRATORY organs, *HAZARDOUS substances, *ENVIRONMENTAL impact analysis, *TOXICITY testing, *LUNG diseases |
| مستخلص: | Highlights • Air–liquid interfaces can be included on inserts, scaffolds and microfluidic chips. • Artificial and decellularized scaffolds enable easy spatial cell organization. • Artificial and decellularized scaffolds effectively mimic extracellular matrix. • Dynamic conditions and breathing motions are easily applied to microfluidic chips. • Microfluidic chips are suitable for high-throughput studies. The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening. Teaser This review describes progress in respiratory system model development and key applications of culture inserts, artificial and decellularized scaffolds, and microfluidic chips as platforms for development of near-to-native lung tissue. [ABSTRACT FROM AUTHOR] |
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