دورية أكاديمية
Long‐Term Outcome of Patients With Intractable Chronic Cluster Headache Treated With Injection of Onabotulinum Toxin A Toward the Sphenopalatine Ganglion – An Observational Study.
| العنوان: | Long‐Term Outcome of Patients With Intractable Chronic Cluster Headache Treated With Injection of Onabotulinum Toxin A Toward the Sphenopalatine Ganglion – An Observational Study. |
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| المؤلفون: | Aschehoug, Irina1 irina.aschehoug@ntnu.no, Bratbak, Daniel Fossum1,2, Tronvik, Erling Andreas1,3,4 |
| المصدر: | Headache: The Journal of Head & Face Pain. Nov2018, Vol. 58 Issue 10, p1519-1529. 11p. 2 Color Photographs, 3 Charts, 1 Graph. |
| مصطلحات موضوعية: | *BOTULINUM toxin, *CLUSTER headache, *HEALTH services accessibility, *LONGITUDINAL method, *NERVE block, *SCIENTIFIC observation, *QUESTIONNAIRES, *TIME, *PILOT projects, *TREATMENT effectiveness, *THERAPEUTICS |
| مستخلص: | Objectives: To investigate long‐term outcomes in per‐protocol chronic cluster headache patients (n = 7), 18 and 24 months after participation in "Pilot study of sphenopalatine injection of onabotulinumtoxinA for the treatment of intractable chronic cluster headache." Methods: Data were collected prospectively through headache diaries, HIT‐6, and open questionnaire forms at 18 and 24 months after the first treatment. Patients had access to repeated injections when needed. Results: An overall significant reduction in cluster headache attack frequency per month (57.3 ± 35.6 at baseline vs 12.4 ± 15.2 at month 18 and 24.6 ± 19.2 at month 24) was found. In addition, there was a reduction in attacks with severe and unbearably intensity (50.0 ± 38.3 at baseline vs 10.1 ± 14.7 at month 18 and 16.6 ± 13.7 at month 24) and an increase in attack free days (4.2 ± 5.9 at baseline vs 19.1 ± 9.4 at month 18 and 12.9 ± 8.8 at month 24). Conclusions: Our findings suggest sustained headache relief after repeated onabotulinumtoxinA injections toward the sphenopalatine ganglion in intractable chronic cluster headache. A placebo‐controlled trial with long‐term follow‐up is warranted. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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