دورية أكاديمية
Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study.
العنوان: | Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study. |
---|---|
المؤلفون: | Aftanas, L. I.1,2 liaftanas@gmail.com, Gevorgyan, M. M.1, Zhanaeva, S. Ya.1, Dzemidovich, S. S.1, Kulikova, K. I.1, Al’perina, E. L.1, Danilenko, K. V.1,2, Idova, G. V.1,2 |
المصدر: | Bulletin of Experimental Biology & Medicine. Jun2018, Vol. 165 Issue 2, p195-199. 5p. |
مصطلحات موضوعية: | *TRANSCRANIAL magnetic stimulation, *NEUROPLASTICITY, *PHYSIOLOGICAL adaptation, *PARKINSON'S disease, *BLOOD serum analysis |
مستخلص: | The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed. [ABSTRACT FROM AUTHOR] |
قاعدة البيانات: | Academic Search Index |
ResultId |
1 |
---|---|
Header |
asx Academic Search Index 131577572 1255 6 Academic Journal academicJournal 1255.25866699219 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=131577572&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
|
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Aftanas%2C+L%2E+I%2E%22">Aftanas, L. I.</searchLink><relatesTo>1,2</relatesTo><i> liaftanas@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Gevorgyan%2C+M%2E+M%2E%22">Gevorgyan, M. M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhanaeva%2C+S%2E+Ya%2E%22">Zhanaeva, S. Ya.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dzemidovich%2C+S%2E+S%2E%22">Dzemidovich, S. S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kulikova%2C+K%2E+I%2E%22">Kulikova, K. I.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Al’perina%2C+E%2E+L%2E%22">Al’perina, E. L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Danilenko%2C+K%2E+V%2E%22">Danilenko, K. V.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Idova%2C+G%2E+V%2E%22">Idova, G. V.</searchLink><relatesTo>1,2</relatesTo> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <searchLink fieldCode="JN" term="%22Bulletin+of+Experimental+Biology+%26+Medicine%22">Bulletin of Experimental Biology & Medicine</searchLink>. Jun2018, Vol. 165 Issue 2, p195-199. 5p. ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => *<searchLink fieldCode="DE" term="%22TRANSCRANIAL+magnetic+stimulation%22">TRANSCRANIAL magnetic stimulation</searchLink><br />*<searchLink fieldCode="DE" term="%22NEUROPLASTICITY%22">NEUROPLASTICITY</searchLink><br />*<searchLink fieldCode="DE" term="%22PHYSIOLOGICAL+adaptation%22">PHYSIOLOGICAL adaptation</searchLink><br />*<searchLink fieldCode="DE" term="%22PARKINSON'S+disease%22">PARKINSON'S disease</searchLink><br />*<searchLink fieldCode="DE" term="%22BLOOD+serum+analysis%22">BLOOD serum analysis</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed. [ABSTRACT FROM AUTHOR] ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1007/s10517-018-4128-4
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 5
[StartPage] => 195
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => TRANSCRANIAL magnetic stimulation
[Type] => general
)
[1] => Array
(
[SubjectFull] => NEUROPLASTICITY
[Type] => general
)
[2] => Array
(
[SubjectFull] => PHYSIOLOGICAL adaptation
[Type] => general
)
[3] => Array
(
[SubjectFull] => PARKINSON'S disease
[Type] => general
)
[4] => Array
(
[SubjectFull] => BLOOD serum analysis
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Aftanas, L. I.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gevorgyan, M. M.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Zhanaeva, S. Ya.
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Dzemidovich, S. S.
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kulikova, K. I.
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Al’perina, E. L.
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Danilenko, K. V.
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Idova, G. V.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 06
[Text] => Jun2018
[Type] => published
[Y] => 2018
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00074888
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 165
)
[1] => Array
(
[Type] => issue
[Value] => 2
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Bulletin of Experimental Biology & Medicine
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |