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أعرض في EDS

Immunophenotypes, apoptosis, and expression of Fas and Bcl-2 from peripheral blood lymphocytes in patients with secondary early syphilis.

التفاصيل البيبلوغرافية
العنوان: Immunophenotypes, apoptosis, and expression of Fas and Bcl-2 from peripheral blood lymphocytes in patients with secondary early syphilis.
المؤلفون: Fan, Yl-Ming1,2, Zeng, Wen-Jun1, Wu, Zhi-Hua1, Li, Shun-Fan1, Fan, Yi-Ming3 (AUTHOR)
المصدر: Sexually Transmitted Diseases. Apr2004, Vol. 31 Issue 4, p221-224. 4p.
مصطلحات موضوعية: *LYMPHOCYTES, *APOPTOSIS, *SYPHILIS, *T cells, *IMMUNE system, *CYTOMETRY
مستخلص: Objectives: Whether syphilis influences lymphocyte apoptosis has not been reported so far.Goal: The goals of this study were to determine whether syphilis influences lymphocyte apoptosis and to investigate the molecular mechanism of apoptosis.Study Design: Peripheral blood lymphocyte (PBL) immunophenotypes, apoptosis, and expression of Fas (CD95) and Bcl-2 were detected by flow cytometry in 33 patients with secondary early syphilis and 30 healthy subjects.Results: Compared with the control subjects, the percentage of CD4 T cells and the ratio of CD4:CD8 were significantly decreased, and that of CD8 T cells and the apoptotic rates of PBLs and CD4 T cells were obviously increased in syphilitic patients. Fas overexpression and Bcl-2 downexpression in the syphilitic group were observed in PBLs and CD4 cells but not in CD8 and CD19 cells.Conclusions: The increased apoptosis of PBLs and CD4 T cells by Fas-mediated death pathway and downexpression of Bcl-2 protein could account for immune dysfunction in secondary early syphilis, which is responsible for the incomplete clearance of Treponema pallidum from the lesions and the chronic infection. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
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Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => <bold>Objectives: </bold>Whether syphilis influences lymphocyte apoptosis has not been reported so far.<bold>Goal: </bold>The goals of this study were to determine whether syphilis influences lymphocyte apoptosis and to investigate the molecular mechanism of apoptosis.<bold>Study Design: </bold>Peripheral blood lymphocyte (PBL) immunophenotypes, apoptosis, and expression of Fas (CD95) and Bcl-2 were detected by flow cytometry in 33 patients with secondary early syphilis and 30 healthy subjects.<bold>Results: </bold>Compared with the control subjects, the percentage of CD4 T cells and the ratio of CD4:CD8 were significantly decreased, and that of CD8 T cells and the apoptotic rates of PBLs and CD4 T cells were obviously increased in syphilitic patients. Fas overexpression and Bcl-2 downexpression in the syphilitic group were observed in PBLs and CD4 cells but not in CD8 and CD19 cells.<bold>Conclusions: </bold>The increased apoptosis of PBLs and CD4 T cells by Fas-mediated death pathway and downexpression of Bcl-2 protein could account for immune dysfunction in secondary early syphilis, which is responsible for the incomplete clearance of Treponema pallidum from the lesions and the chronic infection. [ABSTRACT FROM AUTHOR] )
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