دورية أكاديمية
Differential Expression of Lymphocyte Function-Associated Antigen 1(LFA-1) on Epidermotropic and Non-Epidermotropic T-Cell Clones.
| العنوان: | Differential Expression of Lymphocyte Function-Associated Antigen 1(LFA-1) on Epidermotropic and Non-Epidermotropic T-Cell Clones. |
|---|---|
| المؤلفون: | Shiohara, Tetsuo1, Moriya, Noriko1, Gotoh, Chie1, Hayakawa, Jun, Saizawa, Kaj2, Yagita, Hideo3, Nagashima, Masaji1 |
| المصدر: | Journal of Investigative Dermatology. Dec89, Vol. 93 Issue 6, p804-808. 5p. |
| مصطلحات موضوعية: | *T cells, *IMMUNOGLOBULINS, *EPIDERMIS, *ANTIGENS, *LYMPHOCYTES, *PHORBOL esters |
| مستخلص: | Various T-cell surface molecules are involved in T-cell adhesion, which is an essential requirement for epidermotropic migration of T cells. Our previous studies demonstrated that certain T-cell clones can migrate into the epidermis upon their intradermal inoculation into the footpads of recipients mice with relevant antigens, while other T-cell clones, despite their identical antigen specificities and functions, are non-epidermotropic. We therefore tested whether the differences in epidermotropism of these T cells could reside in the different levels of expression of T-cell surface molecules such as CD3, CD4, CD2, and lymphocyte function associated antigen 1 (LFA-1 was preferentially expressed on the surface of epidermotropic T-cell clones, while non-epidermotropic T-cell clones were negative or very weakly positive for LFA-1 with one exception. After exposure to phorbol ester, epidermotropic clones with high levels of LFA-1 did not show any further up-regulation of LFA-1. In contrast, under identical conditions, significant up-regulation of LFA-1 was observed on non-epidermotropic T cells with low levels of LFA-1. However, even after exposure to phorbol ester, these T cells remained non-epidermotropic. These results suggest that the presence of high levels of LFA-1 on T cells is absolutely necessary for their epidermotropic migration, but its up-regulation is neither necessary nor sufficient to trigger the epidermotropic migration. High levels of LFA-1, regardless of cell activation, may be required to mediate stable cell adhesions leading to epidermotropic migration . [ABSTRACT FROM AUTHOR] |
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