دورية أكاديمية
Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura.
العنوان: | Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura. |
---|---|
المؤلفون: | de la Rubia, Javier1, López, Aurelio1, Arriaga, Francisco1, Cid, Ana Rosa1, Vicente, Ana Isabel1, Marty, Maria Luisa1, Sanz, Miguel A.1 |
المصدر: | Acta Haematologica. 1999, Vol. 102 Issue 1, p12-16. 5p. |
مصطلحات موضوعية: | *PLASMA exchange (Therapeutics), *STEROIDS, *THERAPEUTICS, *THROMBOTIC thrombocytopenic purpura, *THROMBOPENIC purpura |
مستخلص: | We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE) and steroids. Nine patients (82%) achieved complete remission (CR) after a median of 6 rounds of PE (range 2–22). There were 3 early relapses managed in the same way as the initial episode. One patient relapsed 23 months after diagnosis achieving CR with standard therapy; another patient suffered several relapses, and splenectomy was performed after the last one. Three patients died, 2 of them with resistant disease 9 and 38 days after diagnosis, and the remaining one died due to AIDS-related complications while he was in CR. Eight patients are alive in CR with a median follow-up of 38 months (range 8–74). The combination of PE and steroids is a well-tolerated and effective treatment of TTP, but improvements in therapy are needed to manage refractory patients. [ABSTRACT FROM AUTHOR] |
قاعدة البيانات: | Academic Search Index |
ResultId |
1 |
---|---|
Header |
asx Academic Search Index 11333276 1191 6 Academic Journal academicJournal 1190.90551757813 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=11333276&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
|
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22de+la+Rubia%2C+Javier%22">de la Rubia, Javier</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22López%2C+Aurelio%22">López, Aurelio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Arriaga%2C+Francisco%22">Arriaga, Francisco</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cid%2C+Ana+Rosa%22">Cid, Ana Rosa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vicente%2C+Ana+Isabel%22">Vicente, Ana Isabel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marty%2C+Maria+Luisa%22">Marty, Maria Luisa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sanz%2C+Miguel+A%2E%22">Sanz, Miguel A.</searchLink><relatesTo>1</relatesTo> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <searchLink fieldCode="JN" term="%22Acta+Haematologica%22">Acta Haematologica</searchLink>. 1999, Vol. 102 Issue 1, p12-16. 5p. ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => *<searchLink fieldCode="DE" term="%22PLASMA+exchange+%28Therapeutics%29%22">PLASMA exchange (Therapeutics)</searchLink><br />*<searchLink fieldCode="DE" term="%22STEROIDS%22">STEROIDS</searchLink><br />*<searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br />*<searchLink fieldCode="DE" term="%22THROMBOTIC+thrombocytopenic+purpura%22">THROMBOTIC thrombocytopenic purpura</searchLink><br />*<searchLink fieldCode="DE" term="%22THROMBOPENIC+purpura%22">THROMBOPENIC purpura</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE) and steroids. Nine patients (82%) achieved complete remission (CR) after a median of 6 rounds of PE (range 2–22). There were 3 early relapses managed in the same way as the initial episode. One patient relapsed 23 months after diagnosis achieving CR with standard therapy; another patient suffered several relapses, and splenectomy was performed after the last one. Three patients died, 2 of them with resistant disease 9 and 38 days after diagnosis, and the remaining one died due to AIDS-related complications while he was in CR. Eight patients are alive in CR with a median follow-up of 38 months (range 8–74). The combination of PE and steroids is a well-tolerated and effective treatment of TTP, but improvements in therapy are needed to manage refractory patients. [ABSTRACT FROM AUTHOR] ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1159/000040961
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 5
[StartPage] => 12
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => PLASMA exchange (Therapeutics)
[Type] => general
)
[1] => Array
(
[SubjectFull] => STEROIDS
[Type] => general
)
[2] => Array
(
[SubjectFull] => THERAPEUTICS
[Type] => general
)
[3] => Array
(
[SubjectFull] => THROMBOTIC thrombocytopenic purpura
[Type] => general
)
[4] => Array
(
[SubjectFull] => THROMBOPENIC purpura
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => de la Rubia, Javier
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => López, Aurelio
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Arriaga, Francisco
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cid, Ana Rosa
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vicente, Ana Isabel
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Marty, Maria Luisa
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sanz, Miguel A.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 07
[Text] => 1999
[Type] => published
[Y] => 1999
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00015792
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 102
)
[1] => Array
(
[Type] => issue
[Value] => 1
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Acta Haematologica
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |