التفاصيل البيبلوغرافية
| العنوان: |
The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples |
| المؤلفون: |
Franz Konen, Peter Lange, Ulrich Wurster, Konstantin Jendretzky, Stefan Gingele, Nora Möhn, Kurt-Wolfram Sühs, Martin Stangel, Thomas Skripuletz, Philipp Schwenkenbecher |
| المصدر: |
Brain Sciences; Volume 12; Issue 3; Pages: 410 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
cerebrospinal fluid, immunoglobulins, virus-specific antibody index, ventriculo-lumbar gradient, idiopathic intrathecal hypertension, normal pressure hydrocephalus |
| الوصف: |
Background: Cerebrospinal fluid (CSF) samples from patients with non-inflammatory neurological diseases are used for control groups in biomarker studies. Since large amounts of CSF are withdrawn, patients with idiopathic intracranial hypertension (IIH) or normal pressure hydrocephalus (NPH) are especially suitable. The serially taken CSF portions are usually collected in different tubes. We aimed to investigate whether the later random choice of one of these tubes for CSF investigations might harbor the risk of different CSF protein findings due to the so-called ventriculo-lumbar CSF gradient. Methods: Patients with IIH (9) and NPH (7) were included. CSF was serially taken and collected in six tubes of 5 mL each. Concentrations and CSF-serum quotients of immunoglobulins, albumin and the virus-specific antibody index (AI) were determined in the first, fourth and sixth CSF fraction. Results: CSF immunoglobulin and albumin concentrations and CSF-serum protein quotients were significantly lower in the fourth and sixth CSF fraction compared with the first CSF fraction. Virus-specific AI did not significantly differ in the different CSF fractions. Conclusions: CSF protein analytics should be performed in the first CSF fraction in order to avoid different measurement results and achieve comparability within a control group and between different control and patient groups. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Neuropharmacology and Neuropathology; https://dx.doi.org/10.3390/brainsci12030410Test |
| DOI: |
10.3390/brainsci12030410 |
| الإتاحة: |
https://doi.org/10.3390/brainsci12030410Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.EC879ECB |
| قاعدة البيانات: |
BASE |
