المؤلفون: George T. Kedia, Stefan Ückert, Dimitrios Tsikas, Armin J. Becker, Markus A. Kuczyk, Andreas Bannowsky

المصدر: Journal of Clinical Medicine; Volume 9; Issue 9; Pages: 2987

مصطلحات موضوعية: erectile dysfunction (ED), drug treatment, vasoactive compounds, nitric oxide (NO)/cyclic guanosine monophosphate (cyclic GMP), cyclic adenosine monophosphate (cyclic AMP)

وصف الملف: application/pdf

العلاقة: Vascular Medicine; https://dx.doi.org/10.3390/jcm9092987Test

الإتاحة: https://doi.org/10.3390/jcm9092987Test

المؤلفون: Abrahamovych M., Abrahamovych О., Farmaha M.

المصدر: Львівський клінічний вісник, Vol 4, Iss 20, Pp 40-53 (2017)

مصطلحات موضوعية: the improvement of diagnostics and treatment of those patients supposes the studying their pathogenesis. For the time being, the most probable pathogenetic chains are endothelial dysfunction, imbalance in renin-angiotensin-aldosterone system, and also overproduction of brain natriuretic peptide. Aim. To examine the content of vasoactive humoral-metabolic factors, i.e. endothelium-dependent (cyclic guanosine monophosphate, endothelin-1), indexes of renin-aldosterone system (renin, aldosterone) and brain natriuretic hormone in blood plasma in patients with cirrhosis and discover their participation in pathogenesis of comorbid syntropical damages of cardiovascular system. Materials and methods. Randomly with the previous stratification due to the presence of cirrhosis there were 603 patients (445 men (73.8 %) and 158 women (26.2 %) at the age of 19-80 (average age 49.2 ± 10.6) who were treated in the Lviv Regional Hepatological Centre, they had the complex clinical-laboratorial and instrumental research of all organs and systems before treatment due to the orders of the Ministry of Healthcare of Ukraine. Using these results we have seperate 490 (81.3 %) cirrhosis patients with extrahepatic damages of cardiovascular system (investigational group which is stratified into 3 subgroups, i.e. those who have only syntropic cardiomyopathy (103 patients) – group A, only syntropic hypotension (89 patients) – group B and others (306 patients)), and also those who don’t have the damages of cardiovascular system (113 patients, 18.7 %) – the comparison group). Randomly, to achieve the aim the part of the patients from every subgroup (30 patients from A-group, 27 – from B-group and 25 from group of comparison) were screened for the content of the vasoactive humoral-metabolic factorsm. There were 17 almost healthy volunteers of the same gender and age in the control group. Results and discussion. The patients of both investigational groups have reasonably higher number of vasoactive humoral-metabolic factors. In particular, patients with cirrhosis and syntopetic cardiomyopathy dominate the effects of endothelin-1, renin and brain natriuretic peptide, and in patients with cirrhosis and syntropic arterial hypotension – cyclic guanosine monophosphate and aldosterone are the main factors. Additionally we recorded the pathological interaction among vasoactive material. Unlike of the results in comparison group, in patients with liver cirrhosis and syntropic cardiomyopathy, the local vasoactive compounds are in such interactions with each other that result in hyperactivity of the renin-angiotensin-aldosterone system and endothelial dysfunction with a significant increase in both vasoconstrictor endothelin-1 and vasodilator NO, and in patients with liver cirrhosis and arterial hypotension – to severe endothelial dysfunction with overproduction of NO. Conclusions. Cyclic guanosine monophosphate, endothelin-1, renin, aldosterone, and brain natriuretic peptide, have a pathological effect on each other and are involved in the pathogenesis of syntropic damages of the circulatory system in patients with liver cirrhosis. In patients with cirrhosis and syntropic cardiomyopathy, heart damage occurs through toxic myocardial damage due to excessive effects of renin, and brain natriuretic peptide with the onset of systolic and diastolic dysfunction and overload of the heart with blood volume. And in patients with cirrhosis and syntropic arterial hypotension, the damage occurs due to the endothelial dysfunction with excessive cyclic guanosine monophosphate and hyperaldosteronism, which leads to the expansion of peripheral vessels, the depositing of excess blood in the organs and, consequently, brain natriuretic peptide, cyclic guanosine monophosphate, liver cirrhosis, Medicine

وصف الملف: electronic resource

العلاقة: http://lkv.biz/the-content-of-someTest-vasoactive-humoral-metabolic-factors-in-patients-with-cirrhosis-and-their-participation-in-pathogenesis-of-comorbid-syntropical-damages-of-cardiovascular-system/; https://doaj.org/toc/2306-4269Test; https://doaj.org/toc/2520-2898Test

الوصول الحر: https://doaj.org/article/3c3fbfccf1a442b493defbc9f47a4432Test

المؤلفون: M. Farmaha, О. Abrahamovych, М. Abrahamovych

المصدر: Львівський клінічний вісник, Vol 4, Iss 20, Pp 40-53 (2017)

مصطلحات موضوعية: 0301 basic medicine, Cirrhosis, lcsh:Medicine, Gastroenterology, and in patients with liver cirrhosis and arterial hypotension – to severe endothelial dysfunction with overproduction of NO. Conclusions. Cyclic guanosine monophosphate, and brain natriuretic peptide, Pathogenesis, 0302 clinical medicine, aldosterone) and brain natriuretic hormone in blood plasma in patients with cirrhosis and discover their participation in pathogenesis of comorbid syntropical damages of cardiovascular system. Materials and methods. Randomly with the previous stratification due to the presence of cirrhosis there were 603 patients (445 men (73.8 %) and 158 women (26.2 %) at the age of 19-80 (average age 49.2 ± 10.6) who were treated in the Lviv Regional Hepatological Centre, Vasoactive, have a pathological effect on each other and are involved in the pathogenesis of syntropic damages of the circulatory system in patients with liver cirrhosis. In patients with cirrhosis and syntropic cardiomyopathy, and also overproduction of brain natriuretic peptide. Aim. To examine the content of vasoactive humoral-metabolic factors, to achieve the aim the part of the patients from every subgroup (30 patients from A-group, renin and brain natriuretic peptide, only syntropic hypotension (89 patients) – group B and others (306 patients)), the damage occurs due to the endothelial dysfunction with excessive cyclic guanosine monophosphate and hyperaldosteronism, endothelin-1, 030211 gastroenterology & hepatology, heart damage occurs through toxic myocardial damage due to excessive effects of renin, medicine.medical_specialty, i.e. those who have only syntropic cardiomyopathy (103 patients) – group A, they had the complex clinical-laboratorial and instrumental research of all organs and systems before treatment due to the orders of the Ministry of Healthcare of Ukraine. Using these results we have seperate 490 (81.3 %) cirrhosis patients with extrahepatic damages of cardiovascular system (investigational group which is stratified into 3 subgroups, the depositing of excess blood in the organs and, liver cirrhosis, imbalance in renin-angiotensin-aldosterone system, the local vasoactive compounds are in such interactions with each other that result in hyperactivity of the renin-angiotensin-aldosterone system and endothelial dysfunction with a significant increase in both vasoconstrictor endothelin-1 and vasodilator NO, brain natriuretic peptide, 03 medical and health sciences, i.e. endothelium-dependent (cyclic guanosine monophosphate, the most probable pathogenetic chains are endothelial dysfunction, Internal medicine, consequently, medicine, In patient, and also those who don’t have the damages of cardiovascular system (113 patients, 18.7 %) – the comparison group). Randomly, and brain natriuretic peptide with the onset of systolic and diastolic dysfunction and overload of the heart with blood volume. And in patients with cirrhosis and syntropic arterial hypotension, endothelin-1), aldosterone, business.industry, cyclic guanosine monophosphate, lcsh:R, and in patients with cirrhosis and syntropic arterial hypotension – cyclic guanosine monophosphate and aldosterone are the main factors. Additionally we recorded the pathological interaction among vasoactive material. Unlike of the results in comparison group, medicine.disease, 030104 developmental biology, in patients with liver cirrhosis and syntropic cardiomyopathy, renin, indexes of renin-aldosterone system (renin, 27 – from B-group and 25 from group of comparison) were screened for the content of the vasoactive humoral-metabolic factorsm. There were 17 almost healthy volunteers of the same gender and age in the control group. Results and discussion. The patients of both investigational groups have reasonably higher number of vasoactive humoral-metabolic factors. In particular, Damages, patients with cirrhosis and syntopetic cardiomyopathy dominate the effects of endothelin-1, which leads to the expansion of peripheral vessels, business, the improvement of diagnostics and treatment of those patients supposes the studying their pathogenesis. For the time being

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ad091a21da8a3c52cd14a9db640c11Test
http://lkv.biz/the-content-of-someTest-vasoactive-humoral-metabolic-factors-in-patients-with-cirrhosis-and-their-participation-in-pathogenesis-of-comorbid-syntropical-damages-of-cardiovascular-system/

المؤلفون: Claude R. Benedict, Rajbabu Pakala, Shinji Koba, Takashi Katagiri, Takuya Watanabe

المصدر: Japanese Heart Journal. 2002, 43(4):409

المصدر: Cephalalgia. 21(5):549-557

مصطلحات موضوعية: COMMON MIGRAINE, NITRIC-OXIDE, neurogenic inflammation, FACTOR-ALPHA, NEUROGENIC PLASMA EXTRAVASATION, infection, cytokines, stress, vasoactive compounds, TENSION-TYPE HEADACHE, HELICOBACTER-PYLORI, MESSENGER-RNA EXPRESSION, RAT DURA-MATER, CLUSTER HEADACHE, TUMOR-NECROSIS-FACTOR

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dris___00893::8ef03a263b7753d3060a47639ac854f6Test
https://hdl.handle.net/11370/0b44e06a-4c80-4299-8108-9eab64a10c11Test

المؤلفون: Kemper, RHA, Meijler, WJ, Korf, J, Ter Horst, GJ

المصدر: Kemper , RHA , Meijler , WJ , Korf , J & Ter Horst , GJ 2001 , ' Migraine and function of the immune system : a meta-analysis of clinical literature published between 1966 and 1999 ' , Cephalalgia , vol. 21 , no. 5 , pp. 549-557 .

مصطلحات موضوعية: infection, cytokines, vasoactive compounds, neurogenic inflammation, stress, TUMOR-NECROSIS-FACTOR, RAT DURA-MATER, NEUROGENIC PLASMA EXTRAVASATION, MESSENGER-RNA EXPRESSION, TENSION-TYPE HEADACHE, HELICOBACTER-PYLORI, NITRIC-OXIDE, COMMON MIGRAINE, CLUSTER HEADACHE, FACTOR-ALPHA

العلاقة: https://research.rug.nl/en/publications/0b44e06a-4c80-4299-8108-9eab64a10c11Test

الإتاحة: https://hdl.handle.net/11370/0b44e06a-4c80-4299-8108-9eab64a10c11Test
https://research.rug.nl/en/publications/0b44e06a-4c80-4299-8108-9eab64a10c11Test