دورية أكاديمية
Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits
| العنوان: | Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits |
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| المؤلفون: | Ming Qi, Ze Song, Lei Wang, Xu Xie |
| المصدر: | Bioengineered, Vol 12, Iss 2, Pp 12535-12543 (2021) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | vascular embolization agent, temperature-sensitive nanogel, subintimal angioplasty, lower extremity arterial occlusion, Biotechnology, TP248.13-248.65 |
| الوصف: | The study was to explore the effect of subintimal angioplasty (SIA) on the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular endothelial cadherin (VE-cadherin) in the rabbit model of lower extremity arterial occlusion. Specifically, the poly(N-isopropylacrylamide-co-butyl methacrylate) (PIB) temperature-sensitive nanogel was prepared, and the cytotoxicity of direct and indirect contact with PIB temperature-sensitive gel was analyzed then. Subsequently, the PIB temperature-sensitive gel was injected to the New Zealand white rabbit to prepare the lower extremity arterial occlusion model. The healthy control, model group, and SIA group were compared for the serum lipids, fibrinogen (Fbg), fibrinogen (Fbg), and fibrinogen (Fbg) levels. The results showed that the cell proliferation activity and survival rate were always higher than 90% under different concentrations of PIB temperature-sensitive gels. Compared with the model group, the SIA group had increased total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and Fbg levels, but decreased high-density lipoprotein (HDL) level (P < 0.05); decreased TXB2, ET-1, and ICAM-1 levels, but increased levels of 6-Keto-PGF1α and NO (P < 0.05); and decreased sICAM-1 and VE-cadherin levels (P < 0.05). It showed that PIB temperature-sensitive nanogel can elicit vascular embolism, and SIA is suggested in the treatment of lower extremity arterial occlusion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2165-5979 2165-5987 |
| العلاقة: | http://dx.doi.org/10.1080/21655979.2021.2009967Test; https://doaj.org/toc/2165-5979Test; https://doaj.org/toc/2165-5987Test; https://doaj.org/article/099fc8c86f794ed3a0ea3630f9e948a2Test |
| DOI: | 10.1080/21655979.2021.2009967 |
| الإتاحة: | https://doi.org/10.1080/21655979.2021.2009967Test https://doaj.org/article/099fc8c86f794ed3a0ea3630f9e948a2Test |
| رقم الانضمام: | edsbas.A604A3B9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21655979 21655987 |
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| DOI: | 10.1080/21655979.2021.2009967 |