دورية أكاديمية
Ventilator-associated Pneumonia caused by commensal oropharyngeal; a retrospective Analysis of a prospectively collected Database
| العنوان: | Ventilator-associated Pneumonia caused by commensal oropharyngeal; a retrospective Analysis of a prospectively collected Database |
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| المؤلفون: | Scholte, J.B.J., van der Velde, J.I.M., Linssen, C.F.M., van Dessel, H.A., Bergmans, D.C.J.J., Savelkoul, P.H.M., Roekaerts, P.M.H.J., van Mook, W.N.K.A. |
| المصدر: | Scholte , J B J , van der Velde , J I M , Linssen , C F M , van Dessel , H A , Bergmans , D C J J , Savelkoul , P H M , Roekaerts , P M H J & van Mook , W N K A 2015 , ' Ventilator-associated Pneumonia caused by commensal oropharyngeal; a retrospective Analysis of a prospectively collected Database ' , BMC Pulmonary Medicine , vol. 15 , 86 . https://doi.org/10.1186/s12890-015-0087-yTest |
| سنة النشر: | 2015 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Ventilator-associated pneumonia, Bronchoalveolar lavage, Commensal oropharyngeal flora, Intensive care unit, MALDI-TOF-MS, BRONCHOALVEOLAR LAVAGE FLUID, INTENSIVE-CARE UNITS, CRITICALLY-ILL PATIENTS, ANTIBIOTIC-THERAPY, PULMONARY INFECTIONS, NEUTROPENIC PATIENTS, CYSTIC-FIBROSIS, SOFA SCORE, DIAGNOSIS, METAANALYSIS |
| الوصف: | BACKGROUND: The significance of commensal oropharyngeal flora (COF) as a potential cause of ventilator-associated pneumonia (VAP) is scarcely investigated and consequently unknown. Therefore, the aim of this study was to explore whether COF may cause VAP. METHODS: Retrospective clinical, microbiological and radiographic analysis of all prospectively collected suspected VAP cases in which bronchoalveolar lavage fluid exclusively yielded >/= 10(4) cfu/ml COF during a 9.5-year period. Characteristics of 899 recent intensive care unit (ICU) admissions were used as a reference population. RESULTS: Out of the prospectively collected database containing 159 VAP cases, 23 patients were included. In these patients, VAP developed after a median of 8 days of mechanical ventilation. The patients faced a prolonged total ICU length of stay (35 days [P < .001]), hospital length of stay (45 days [P = .001]), and a trend to higher mortality (39 % vs. 26 %, [P = .158]; standardized mortality ratio 1.26 vs. 0.77, [P = .137]) compared to the reference population. After clinical, microbiological and radiographic analysis, COF was the most likely cause of respiratory deterioration in 15 patients (9.4 % of all VAP cases) and a possible cause in 2 patients. CONCLUSION: Commensal oropharyngeal flora appears to be a potential cause of VAP in limited numbers of ICU patients as is probably associated with an increased length of stay in both ICU and hospital. As COF-VAP develops late in the course of ICU admission, it is possibly associated with the immunocompromised status of ICU patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12890-015-0087-y |
| الإتاحة: | https://doi.org/10.1186/s12890-015-0087-yTest https://cris.maastrichtuniversity.nl/en/publications/cc127aa4-57a0-48bc-a50e-baa2b1de7741Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7A849FC1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12890-015-0087-y |
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