Prevalence and Evolution of Susceptibility-Weighted Imaging Lesions in Patients With Artificial Heart Valves
| العنوان: | Prevalence and Evolution of Susceptibility-Weighted Imaging Lesions in Patients With Artificial Heart Valves |
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| المؤلفون: | Jan Gralla, Thomas Raphael Meinel, Philipe Sebastian Breiding, Urs Fischer, Thomas Pilgrim, Felix Zibold, Simon Jung, Florian Schönhoff, Thierry Carrel, Marcel Arnold, Johannes Kaesmacher, Felix G. Meinel, Jana T Duerrenmatt |
| المصدر: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Breiding, Philipe Sebastian; Duerrenmatt, Jana T; Meinel, Felix G; Carrel, Thierry; Schönhoff, Florian; Zibold, Felix; Kaesmacher, Johannes; Gralla, Jan; Pilgrim, Thomas; Jung, Simon; Fischer, Urs; Arnold, Marcel; Meinel, Thomas R (2019). Prevalence and Evolution of Susceptibility-Weighted Imaging Lesions in Patients With Artificial Heart Valves. Journal of the American Heart Association, 8(15), e012814. American Heart Association 10.1161/JAHA.119.012814 <http://dx.doi.org/10.1161/JAHA.119.012814Test> |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, Magnetic Resonance Imaging (MRI), Aortic Valve Replacement/Transcather Aortic Valve Implantation, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Postoperative Complications, law, Catheter-Based Coronary and Valvular Interventions, Prevalence, 610 Medicine & health, Original Research, Cardiopulmonary Bypass, medicine.diagnostic_test, Thrombolysis, heart valve, Middle Aged, Magnetic Resonance Imaging, Stroke, medicine.anatomical_structure, Heart Valve Prosthesis, Susceptibility weighted imaging, Cardiology, Female, Cerebral amyloid angiopathy, Cardiology and Cardiovascular Medicine, valve abrasion, medicine.medical_specialty, 03 medical and health sciences, Artificial heart, Internal medicine, susceptibility‐weighted imaging, medicine, Cardiopulmonary bypass, Humans, Heart valve, Risk factor, cerebral amyloid angiopathy, Aged, Retrospective Studies, Ischemic Stroke, Intracranial Hemorrhage, business.industry, Magnetic resonance imaging, medicine.disease, amyloid angiopathy, cerebral microbleed, business, 030217 neurology & neurosurgery |
| الوصف: | Background In patients with mechanical heart valves, cerebral susceptibility‐weighted imaging ( SWI ) lesions on magnetic resonance imaging, postulated to be caused by degenerative metallic abrasion, are frequently referred to as valve abrasion . It remains unclear whether valve implantation not requiring cardiopulmonary bypass or biological heart valves also shows those lesions. Methods and Results Two blinded readers rated SWI lesions and cerebral amyloid angiopathy probability according to established criteria on brain magnetic resonance imaging pre‐ and postinterventionally. We assessed the association between valve type/cardiopulmonary bypass use and SWI lesion count on the first postinterventional scan using multivariable logistic regression. On postinterventional magnetic resonance imaging, 57/58 (98%) patients with mechanical heart valves had at least 1 and 46/58 (79%) 3 or more SWI lesions, while 92/97 (95%) patients with biological heart valves had at least 1 and 72/97 (74%) 3 or more SWI lesions. On multivariate analysis, duration of cardiopulmonary bypass during implantation significantly increased the odds of having SWI lesions on the first postinterventional magnetic resonance imaging (β per 10 minutes 0.498; 95% CI , 0.116–0.880; P =0.011), whereas valve type showed no significant association ( P =0.338). Thirty‐seven of 155 (23.9%) patients fulfilled the criteria of possible/probable cerebral amyloid angiopathy. Conclusions SWI lesions in patients with artificial heart valves evolve around the time point of valve implantation and the majority of patients had multiple lesions. The missing association with the valve type weakens the hypothesis of degenerative metallic abrasion and highlights cardiopulmonary bypass as the main risk factor for SWI occurrence. SWI lesions associated with cardiac procedures can mimic cerebral amyloid angiopathy. Further research needs to clarify whether those lesions are associated with intracranial hemorrhage after intravenous thrombolysis or anticoagulation. |
| وصف الملف: | application/pdf |
| تدمد: | 2047-9980 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c9ad056a9a17ac7f72305b1ed2c990Test https://pubmed.ncbi.nlm.nih.gov/31379252Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72c9ad056a9a17ac7f72305b1ed2c990 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20479980 |
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