دورية أكاديمية
MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery
| العنوان: | MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery |
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| المؤلفون: | Cara E. Brocklehurst, Eva Altmann, Corentin Bon, Holly Davis, David Dunstan, Peter Ertl, Carol Ginsburg-Moraff, Jonathan Grob, Daniel J. Gosling, Guillaume Lapointe, Alexander N. Marziale, Heinrich Mues, Marco Palmieri, Sophie Racine, Richard I. Robinson, Clayton Springer, Kian Tan, William Ulmer, René Wyler |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Pharmacology, Developmental Biology, Inorganic Chemistry, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, using microscale chemistry, time frame never, throughput assay technology, robotic liquid handling, incorporates recent advances, every learning cycle, enable rapid access, drug discovery projects, based microscale chemistry, active learning models, accelerate drug discovery, reorienting existing high, modular technology platform, situ quantification, relevant data, property space, multiparameter exploration, herein describe, hereby driven, generating knowledge, full package, automated purification |
| الوصف: | We herein describe the development and application of a modular technology platform which incorporates recent advances in plate-based microscale chemistry, automated purification, in situ quantification, and robotic liquid handling to enable rapid access to high-quality chemical matter already formatted for assays. In using microscale chemistry and thus consuming minimal chemical matter, the platform is not only efficient but also follows green chemistry principles. By reorienting existing high-throughput assay technology, the platform can generate a full package of relevant data on each set of compounds in every learning cycle. The multiparameter exploration of chemical and property space is hereby driven by active learning models. The enhanced compound optimization process is generating knowledge for drug discovery projects in a time frame never before possible. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/MicroCycle_An_Integrated_and_Automated_Platform_to_Accelerate_Drug_Discovery/25062534Test |
| DOI: | 10.1021/acs.jmedchem.3c02029.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.jmedchem.3c02029.s001Test https://figshare.com/articles/journal_contribution/MicroCycle_An_Integrated_and_Automated_Platform_to_Accelerate_Drug_Discovery/25062534Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.D53FE65A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jmedchem.3c02029.s001 |
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