التفاصيل البيبلوغرافية
| العنوان: |
Heterogeneous Iridium-Catalyzed Carbene N–H Bond Insertion with α‑Alkyl Diazo Esters |
| المؤلفون: |
Ping Guo, Yan Chen, Lei Tao, Shufang Ji, Ruixue Zhang, Zedong Zhang, Xiao Liang, Dingsheng Wang, Yadong Li, Jie Zhao |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Biotechnology, Immunology, Marine Biology, Hematology, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, two reactive sites, remarkable selectivity observed, mechanism study revealed, chiral diamino substrate, carbene insertion reaction, aryl amines coupled, alkyl diazo esters, atom site catalyst, heterogeneous iridium single, heterogeneous iridium, catalyst loading, hydride elimination, either β, 23 mol |
| الوصف: |
A heterogeneous iridium single-atom site catalyst (Ir-SA) was synthesized and investigated in catalyzing the carbene insertion reaction with challenging α-alkyl diazo ester substrates. With only 0.23 mol % catalyst loading, our Ir-SA demonstrated remarkable performance in heterogeneous carbene N–H bond insertion reactions involving various (hetero) aryl amines coupled with α-alkyl diazo esters. Notably, in the case of using a chiral diamino substrate with two reactive sites, Ir-SA exhibited high selectivity toward single carbene N–H insertion, leading to the generation of a class of unsymmetric chiral diamino ligands. Further mechanism study revealed that the lower activation barrier associated with the single N–H bond insertion step, as compared to either β-hydride elimination or downstream dual N–H bond insertion, accounted for the remarkable selectivity observed in this carbene insertion reaction catalyzed by Ir-SA. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Heterogeneous_Iridium-Catalyzed_Carbene_N_H_Bond_Insertion_with_Alkyl_Diazo_Esters/25399111Test |
| DOI: |
10.1021/acscatal.3c05635.s001 |
| الإتاحة: |
https://doi.org/10.1021/acscatal.3c05635.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.C31F8ACA |
| قاعدة البيانات: |
BASE |
