دورية أكاديمية
Microglia-derived microvesicles affect microglia phenotype in glioma
| العنوان: | Microglia-derived microvesicles affect microglia phenotype in glioma |
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| المؤلفون: | Grimaldi, Alfonso, SERPE, Carmela, Chece, Giuseppina, Nigro, Valentina, Sarra, Angelo, Ruzicka, Barbara, Relucenti, Michela, Familiari, Giuseppe, Ruocco, Giancarlo, Pascucci, Giuseppe Rubens, Guerrieri, Francesca, Limatola, Cristina, Catalano, Myriam |
| المساهمون: | Grimaldi, Alfonso, Serpe, Carmela, Chece, Giuseppina, Nigro, Valentina, Sarra, Angelo, Ruzicka, Barbara, Relucenti, Michela, Familiari, Giuseppe, Ruocco, Giancarlo, Pascucci, Giuseppe Ruben, Guerrieri, Francesca, Limatola, Cristina, Catalano, Myriam |
| بيانات النشر: | Frontiers Research Foundation Lausanne |
| سنة النشر: | 2019 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | microglia, extracellular vesicle, tumor associated myeloid cell, brain tumor, glioma |
| الوصف: | Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to preserve brain homeostasis and, when dysfunctional, involved in several CNS diseases. We investigated whether microglia-derived EVs could be used to transfer a protective phenotype to dysfunctional microglia in the context of a brain tumor. When MV, isolated from microglia stimulated with LPS/IFNg were brain injected in glioma-bearing mice, we observed a phenotype switch of tumor associated myeloid cells (TAMs) and a reduction of tumor size. Our findings indicate that the MV cargo, which contains upregulated transcripts for several inflammation-related genes, can transfer information in the brain of glioma bearing mice modifying microglial gene expression, reducing neuronal death and glioma invasion, thus promoting the recovery of brain homeostasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30853898; info:eu-repo/semantics/altIdentifier/wos/WOS:000459391200001; volume:13; firstpage:1; lastpage:14; numberofpages:14; journal:FRONTIERS IN CELLULAR NEUROSCIENCE; http://hdl.handle.net/11573/1239819Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85064210119 |
| DOI: | 10.3389/fncel.2019.00041 |
| الإتاحة: | https://doi.org/10.3389/fncel.2019.00041Test http://hdl.handle.net/11573/1239819Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DB388F2C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fncel.2019.00041 |
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