المؤلفون: Petr G Vikhorev, Natalia N Vikhoreva, WaiChun Yeung, Amy Li, Sean Lal, Cristobal G dos Remedios, Cheavar A Blair, Maya Guglin, Kenneth S Campbell, Magdi H Yacoub, Pieter de Tombe, Steven B Marston

مصطلحات موضوعية: Uncategorized, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Dilated cardiomyopathy, Titin, Cardiac contractility and energetics, Length-dependent activation, Super-relaxed state of myosin, BINDING PROTEIN-C, TROPONIN-I PHOSPHORYLATION, HEART-FAILURE, HUMAN MYOCARDIUM, PASSIVE STIFFNESS, STRESS, THICK, CONTRACTION, EXPRESSION, GENETICS, Super- relaxed state of myosin, Adult, Cardiomyopathy, Dilated, Carrier Proteins, Connectin, Cyclic AMP-Dependent Protein Kinases, Female, Genetic Predisposition to Disease, Humans

العلاقة: https://figshare.com/articles/journal_contribution/Titin-truncating_mutations_associated_with_dilated_cardiomyopathy_alter_length-dependent_activation_and_its_modulation_via_phosphorylation/19697221Test

الإتاحة: https://doi.org/10.26181/19697221.v1Test
https://figshare.com/articles/journal_contribution/Titin-truncating_mutations_associated_with_dilated_cardiomyopathy_alter_length-dependent_activation_and_its_modulation_via_phosphorylation/19697221Test

المؤلفون: Marston, S, Alsulami, K

المصدر: 30 ; 1

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, contractility, sarcomere, cardiomyopathy, crossbridge cycle, therapeutics, drug trials, CARDIAC MYOSIN ACTIVATOR, POTENTIAL THERAPEUTIC APPROACH, OMECAMTIV MECARBIL INCREASES, DILATED CARDIOMYOPATHY MUTATIONS, MYOCARDIAL OXYGEN-CONSUMPTION, TROPONIN-I PHOSPHORYLATION, HYPERTROPHIC CARDIOMYOPATHY, DOUBLE-BLIND, CALCIUM SENSITIVITY, GREEN TEA, Chemical Physics, 0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences

العلاقة: International Journal of Molecular Sciences; http://hdl.handle.net/10044/1/84991Test

الإتاحة: https://doi.org/10.3390/ijms21249599Test
http://hdl.handle.net/10044/1/84991Test

المؤلفون: Marston, S

المصدر: 76 ; 69

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Myosin, Actin, Troponin, Tropomyosin, Contraction, Small molecules, Regulation, DEPENDENT ADENOSINE-TRIPHOSPHATASE, TROPONIN-I PHOSPHORYLATION, CARDIAC MYOSIN ACTIVATION, LINKED CALCIUM REGULATION, DILATED CARDIOMYOPATHY, OMECAMTIV MECARBIL, HYPERTROPHIC CARDIOMYOPATHY, INHIBITORY SUBUNIT, NEMALINE MYOPATHY, CA2+ SENSITIVITY, Physiology, 0601 Biochemistry and Cell Biology, 0606 Physiology

جغرافية الموضوع: Netherlands

العلاقة: Journal of Muscle Research and Cell Motility; http://hdl.handle.net/10044/1/71043Test

الإتاحة: https://doi.org/10.1007/s10974-019-09526-wTest
http://hdl.handle.net/10044/1/71043Test

المؤلفون: Alice Sheehan, Andrew E. Messer, Maria Papadaki, Afnan Choudhry, Vladimír Kren, David Biedermann, Brian Blagg, Anuj Khandelwal, Steven B. Marston

المصدر: Frontiers in Physiology, Vol 9 (2018)

مصطلحات موضوعية: cardiomyopathy, sarcomeric protein mutations, troponin I phosphorylation, PKA, Ca2+ regulation, small molecule pharmacology, Physiology, QP1-981

وصف الملف: electronic resource

العلاقة: http://journal.frontiersin.org/article/10.3389/fphys.2018.00243/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/9f4cc4a1c9ae44e7b2ed21de81cc6c4fTest

المؤلفون: Sheehan, Alice, Messer, Andrew E., Papadaki, Maria, Choudhry, Afnan, Kren, Vladimír, Biedermann, David, Blagg, Brian S. J., Khandelwal, Anuj, Marston, Steven B.

مصطلحات موضوعية: Cardiomyopathy, Sarcomeric protein mutations, Troponin I phosphorylation, PKA, Ca2+ regulation, Small molecule pharmacology, EGCG, Silybin

وصف الملف: application/pdf

العلاقة: Sheehan, A., Messer, A. E., Papadaki, M., Choudhry, A., Kren, V., Biedermann, D., … Marston, S. B. (2018). Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin. Frontiers in Physiology, 9, 243. http://doi.org/10.3389/fphys.2018.00243Test; http://hdl.handle.net/1808/26501Test; orcid:0000-0003-4492-4400

الإتاحة: https://doi.org/10.3389/fphys.2018.00243Test
http://hdl.handle.net/1808/26501Test

المؤلفون: Marston, SB

المساهمون: British Heart Foundation

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, actin, myosin, myopathy, mutation, contractility, Ca2+-regulation, A-triad, super relaxed state, myosin mesa, FAMILIAL HYPERTROPHIC CARDIOMYOPATHY, BETA-CARDIAC MYOSIN, MUSCLE THIN FILAMENT, TROPONIN-I PHOSPHORYLATION, DILATED CARDIOMYOPATHY, NEMALINE MYOPATHY, MOUSE MODEL, ALPHA-ACTIN, PAPILLARY-MUSCLE, NATURAL-HISTORY, 0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences, Chemical Physics

العلاقة: International Journal of Molecular Sciences; http://hdl.handle.net/10044/1/62594Test; https://dx.doi.org/10.3390/ijms19072020Test; RG/11/20/29266

الإتاحة: https://doi.org/10.3390/ijms19072020Test
http://hdl.handle.net/10044/1/62594Test

المؤلفون: Surdo, NC, Berrera, M, Koschinski, A, Brescia, M, Machado, MR, Carr, C, Wright, P, Gorelik, J, Morotti, S, Grandi, E, Bers, DM, Pantano, S, Zaccolo, M

المساهمون: Medical Research Council (MRC), British Heart Foundation

مصطلحات موضوعية: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, TROPONIN-I PHOSPHORYLATION, PROTEIN-KINASE-A, HEART-FAILURE, CYCLIC-AMP, INTACT-CELLS, CALCIUM, TIME, PHOSPHODIESTERASES, MYOFILAMENTS, RELAXATION, Adrenergic beta-Agonists, Amino Acid Sequence, Animals, Biosensing Techniques, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Cyclic AMP, Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit, Fluorescence Resonance Energy Transfer, Isoproterenol, Luminescent Proteins, Male, Myocardial Contraction, Myocytes

العلاقة: Nature Communications; http://hdl.handle.net/10044/1/48424Test; MR/L006855/1; RG/12/18/30088

الإتاحة: https://doi.org/10.1038/ncomms15031Test
http://hdl.handle.net/10044/1/48424Test

المؤلفون: Messer, AE, Chan, WS, Daley, A, Copeland, O, Marston, SB, Connolly, D

المساهمون: British Heart Foundation

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Physiology, Felix catus, Ragdoll cat, hypertrophic cardiomyopathy, cardiac muscle, Ca2+ regulation, troponin, phosphorylation, uncoupling/recoupling, TROPONIN-I PHOSPHORYLATION, HUMAN HEART-MUSCLE, MAINE COON CATS, APPARENTLY HEALTHY CATS, HUMAN-DISEASE, ANIMAL-MODEL, RAGDOLL CATS, C MUTATION, SPHYNX CAT, ASSOCIATION

العلاقة: Frontiers in Physiology; http://hdl.handle.net/10044/1/48573Test; https://dx.doi.org/10.3389/fphys.2017.00348Test; RG/11/20/29266

الإتاحة: https://doi.org/10.3389/fphys.2017.00348Test
http://hdl.handle.net/10044/1/48573Test

المؤلفون: Ravichandran, Vani

مصطلحات موضوعية: Heart failure, myofilaments, sarcomeres, troponin, troponin I, troponin I phosphorylation, mitochondrial dysfunction, Science General, Science

الإتاحة: https://doi.org/10.7302/4798Test
http://deepblue.lib.umich.edu/handle/2027.42/172769Test

المؤلفون: Maria Papadaki, Adam Jacques, Andrew E. Messer, Emma Dyer, Steven B. Marston, Christopher R. Bayliss, Massimiliano Memo

المصدر: Biophysical Reviews

مصطلحات موضوعية: Sydney Heart Bank, medicine.medical_specialty, In vitro motility, Biophysics, Review, Contractility, Human myocardium, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Internal medicine, Troponin I, medicine, Normal heart, Molecular Biology, Troponin I phosphorylation, 030304 developmental biology, Donor heart, 0303 health sciences, business.industry, Human heart, Cardiology, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ff120f274e2e5ba4c5aa1024e0aee2Test
https://doi.org/10.1007/s12551-020-00740-2Test