دورية أكاديمية
Arsenite S ‑Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120
| العنوان: | Arsenite S ‑Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120 |
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| المؤلفون: | Jianwei Li, Zhipeng Yin, Kun Xu, Li Yan, Li Ye, Jingjing Du, Chuanyong Jing, Jianbo Shi |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Microbiology, Genetics, Molecular Biology, Ecology, Sociology, Inorganic Chemistry, Biological Sciences not elsewhere classified, three conserved cysteines, paddy soil cultures, high metabolic potential, even global scale, >‑ adenosylmethionine methyltransferase, >- adenosylmethionine methyltransferase, gaseous methylated species, trimethylated sb species, sb biogeochemical cycling, methylated sb species, converting intracellular sb, preferred arsm substrate, gaseous phase, mobilizing sb, catalyze sb, uninformed process, study shows, readily coordinated, phylogenetic analysis, pcc7120 antimony, great diversity, emerging contaminant, detoxification process |
| الوصف: | Antimony (Sb) biomethylation is an important but uninformed process in Sb biogeochemical cycling. Methylated Sb species have been widely detected in the environment, but the gene and enzyme for Sb methylation remain unknown. Here, we found that arsenite S -adenosylmethionine methyltransferase (ArsM) is able to catalyze Sb(III) methylation. The stepwise methylation by ArsM forms mono-, di-, and trimethylated Sb species. Sb(III) is readily coordinated with glutathione, forming the preferred ArsM substrate which is anchored on three conserved cysteines. Overexpressing arsM in Escherichia coli AW3110 conferred resistance to Sb(III) by converting intracellular Sb(III) into gaseous methylated species, serving as a detoxification process. Methylated Sb species were detected in paddy soil cultures, and phylogenetic analysis of ArsM showed its great diversity in ecosystems, suggesting a high metabolic potential for Sb(III) methylation in the environment. This study shows an undiscovered microbial process methylating aqueous Sb(III) into the gaseous phase, mobilizing Sb on a regional and even global scale as a re-emerging contaminant. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Arsenite_i_S_i_Adenosylmethionine_Methyltransferase_Is_Responsible_for_Antimony_Biomethylation_in_i_Nostoc_i_sp_PCC7120/24949366Test |
| DOI: | 10.1021/acs.est.3c07367.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.est.3c07367.s001Test https://figshare.com/articles/journal_contribution/Arsenite_i_S_i_Adenosylmethionine_Methyltransferase_Is_Responsible_for_Antimony_Biomethylation_in_i_Nostoc_i_sp_PCC7120/24949366Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.6E72819C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.est.3c07367.s001 |
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