التفاصيل البيبلوغرافية
| العنوان: |
Density Functional Theory Calculation May Confirm Arsenic–Thiol Adhesion as the Primary Mechanism of Arsenical Toxicity |
| المؤلفون: |
Meng-Han Tsai, Ying-Ting Lin |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Genetics, Biotechnology, Ecology, Cancer, Inorganic Chemistry, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, transition states associated, metabolized intermediate known, including proton transfer, frequency vibration mode, detoxify inorganic arsenic, v , iii , increasing energy barriers, five arsenicals reacting, arsenical toxicity previously, arsenic thiol adhesion, mol ), dma, arsenite, arsenate, energy barriers, arsenic ’, arsenic toxicity, arsenic binding |
| الوصف: |
Previously, it was believed that methylation was the body’s primary method to detoxify inorganic arsenic. However, recent research has shown that the metabolized intermediate known as MMA III is more toxic than arsenite and arsenate, contradicting a previous understanding. Another important question arises: is arsenical toxicity truly caused by arsenic binding to proteins through arsenic thiol adhesion? Based on the toxicity order of the experiment, with MMA III being the most toxic, followed by arsenite, arsenate, DMA V , and MMA V , density functional theory (DFT) calculations can provide a straightforward assessment of this issue. Our practice captures all the transition states associated with a specific imaginary-frequency vibration mode, including proton transfer and simultaneous departure of leaving group. We have obtained the energy barriers for five arsenicals reacting with thiol, alcohol, and amine separately. In addition to energetic favorability, the following are the energy barriers for arsenic’s reaction with thiol ranked from low to high: MMA III (25.4 kcal/mol), arsenite (27.7 kcal/mol), arsenate (32.8 kcal/mol), DMA V (36.2 kcal/mol), and MMA V (38.3 kcal/mol). Results show that the toxicity of arsenicals is mainly caused by their reaction with thiol rather than with alcohol or amine, as supported by the trend of decreasing toxicity and increasing energy barriers. Thus, this DFT calculation may confirm the paradigm that arsenic–thiol adhesion is the primary cause of arsenic toxicity in the body. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Density_Functional_Theory_Calculation_May_Confirm_Arsenic_Thiol_Adhesion_as_the_Primary_Mechanism_of_Arsenical_Toxicity/25403640Test |
| DOI: |
10.1021/acsomega.3c09269.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsomega.3c09269.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.B388EA31 |
| قاعدة البيانات: |
BASE |
