المؤلفون: Zhao, Xutong, Sun, Jing, Huang, Dalong

المصدر: J Biopharm Stat ; ISSN:1520-5711

مصطلحات موضوعية: Concentration-QTc model, cardiac safety assessment, meta-analysis, safety margin, thorough QT study

العلاقة: https://doi.org/10.1080/10543406.2024.2365972Test; https://pubmed.ncbi.nlm.nih.gov/38875133Test

الإتاحة: https://doi.org/10.1080/10543406.2024.2365972Test
https://pubmed.ncbi.nlm.nih.gov/38875133Test

المؤلفون: Markus S. Mueller, Patricia N. Sidharta, Christine Voors-Pette, Borje Darpo, Hongqi Xue, Jasper Dingemanse

المصدر: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-15 (2020)

مصطلحات موضوعية: Lucerastat, Glucosylceramide synthase inhibitor, Fabry disease, QT interval, Thorough QT study, Medicine

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13023-020-01582-7Test; https://doaj.org/toc/1750-1172Test

الوصول الحر: https://doaj.org/article/f0abba24de554ee6a78152eb628f9a5eTest

المؤلفون: Li-yu Liang, Ying-chun He, Yun-fei Li, Juan Yang, Feng-yan Xu, Lu-jin Li, Ji-han Huang, Kun Wang, Qing-shan Zheng

المصدر: Biomedicine & Pharmacotherapy, Vol 130, Iss , Pp 110619- (2020)

مصطلحات موضوعية: Antofloxacin, QT interval prolongation, Thorough QT study, Population modeling, False-positive rate, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S075333222030812XTest; https://doaj.org/toc/0753-3322Test

الوصول الحر: https://doaj.org/article/79ce4a23422045b390252935e0c2eaf6Test

المؤلفون: Funck-Brentano, Christian, Felices, Mathieu, Fur, Nathalie Le, Dubourdieu, Corinne, Desché, Pierre, Vanhoutte, Frédéric, Voiriot, Pascal

المساهمون: Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

المصدر: ISSN: 0306-5251.

مصطلحات موضوعية: QTc interval, gadopiclenol, healthy subjects, osmolarity, thorough QT study, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32302009; hal-02875281; https://hal.sorbonne-universite.fr/hal-02875281Test; https://hal.sorbonne-universite.fr/hal-02875281/documentTest; https://hal.sorbonne-universite.fr/hal-02875281/file/MP-00973-19%20TQT%20manuscript%20gadopiclenol%20for%20BJCP%20FINAL%20pour%20HAL.pdfTest; PUBMED: 32302009

الإتاحة: https://doi.org/10.1111/bcp.14309Test
https://hal.sorbonne-universite.fr/hal-02875281Test
https://hal.sorbonne-universite.fr/hal-02875281/documentTest
https://hal.sorbonne-universite.fr/hal-02875281/file/MP-00973-19%20TQT%20manuscript%20gadopiclenol%20for%20BJCP%20FINAL%20pour%20HAL.pdfTest

المؤلفون: Grenier J, Paglialunga S, Morimoto BH, Lester RM

المصدر: Drug, Healthcare and Patient Safety, Vol Volume 10, Pp 27-36 (2018)

مصطلحات موضوعية: Concentration-effect modeling, Thorough QT study, Intensive ECG collection, Intersection Union Test, QT/QTc, Assay sensitivity, Positive control, Moxifloxacin, Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/evaluating-cardiac-risk-exposure-response-analysis-in-early-clinical-d-peer-reviewed-article-DHPSTest; https://doaj.org/toc/1179-1365Test

الوصول الحر: https://doaj.org/article/1f0485c562cc4f3c8bd089fb0cd0c0c4Test

المؤلفون: Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

المصدر: Drug Design, Development and Therapy, Vol Volume 10, Pp 3509-3517 (2016)

مصطلحات موضوعية: lesinurad, maximum tolerated dose study, QT interval, selective uric acid reabsorption inhibitor, thorough QT study, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/supratherapeutic-dose-evaluation-and-effect-of-lesinurad-on-cardiac-re-peer-reviewed-article-DDDTTest; https://doaj.org/toc/1177-8881Test

الوصول الحر: https://doaj.org/article/956896beeaa84ecd8a54888ca1c29996Test

المؤلفون: Robert M. Lester

المصدر: Clinical Pharmacology in Drug Development

مصطلحات موضوعية: Questions and answers, Heart Diseases, Best practice, Drug Evaluation, Preclinical, Pharmaceutical Science, Harmonization, Review, Food and drug administration, Drug Development, Animals, Humans, Medicine, hERG, Pharmacology (medical), Drug Labeling, Product Labeling, United States Food and Drug Administration, business.industry, Liability, cardiac liability, concentration response analysis, thorough QT study (TQT), Cardiotoxicity, United States, Risk analysis (engineering), Drug development, proarrhythmia risk, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7abefaa53a7bd47024b9f839280f80Test
https://doi.org/10.1002/cpdd.1003Test

المؤلفون: Matthew Butler, Danielle McGeeney, Antonia Periclou, Li Yao, Brian McNamee, Lisa Borbridge, Ramesh Boinpally

المصدر: Clinical Pharmacology in Drug Development

مصطلحات موضوعية: Adult, Male, Adolescent, Pyridines, Moxifloxacin, Pharmaceutical Science, Original Manuscript, atogepant, thorough QT study, Placebo, 030226 pharmacology & pharmacy, QT interval, Electrocardiography, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Calcitonin gene-related peptide receptor antagonist, Double-Blind Method, Piperidines, migraine disorders, Calcitonin Gene-Related Peptide Receptor Antagonists, Humans, Medicine, Pyrroles, Spiro Compounds, Pharmacology (medical), Adverse effect, Cross-Over Studies, business.industry, Articles, Assay sensitivity, Crossover study, Confidence interval, Long QT Syndrome, Area Under Curve, 030220 oncology & carcinogenesis, Anesthesia, Female, cardiac repolarization, business, calcitonin gene–related peptide receptor antagonist, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5746721d8d548bc4cbc43c5e349ed9Test
https://doi.org/10.1002/cpdd.940Test

المؤلفون: Jay Mason, Thomas Moon

المصدر: Antibiotics; Volume 6; Issue 1; Pages: 5

مصطلحات موضوعية: moxifloxacin, heart rate, thorough QT study

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/antibiotics6010005Test

الإتاحة: https://doi.org/10.3390/antibiotics6010005Test

المؤلفون: Mamodikoe Makhene, Blaire Osborn, Wael El-Amin, George A Saviolakis, Tian J. Yang, Mengchun Li, Jerry R Nedelman, Daniel Everitt

المصدر: Clinical Pharmacology in Drug Development

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Moxifloxacin, Antitubercular Agents, Pharmaceutical Science, Context (language use), Original Manuscript, thorough QT study, 030226 pharmacology & pharmacy, QT interval, 03 medical and health sciences, chemistry.chemical_compound, Electrocardiography, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Internal medicine, medicine, Humans, Pharmacology (medical), Drug Interactions, Dosing, Cross-Over Studies, Dose-Response Relationship, Drug, business.industry, PA‐824, Articles, Middle Aged, Crossover study, Regimen, Long QT Syndrome, chemistry, tuberculosis, Nitroimidazoles, 030220 oncology & carcinogenesis, pretomanid, Female, Bedaquiline, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e9cc7d60794e9e69f8faf1347a3e4cTest
http://europepmc.org/articles/PMC8246780Test