التفاصيل البيبلوغرافية
| العنوان: |
Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-κBTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway |
| المؤلفون: |
Janka Leskovská, Natalia Miklášová, Paul Milan Kubelac, Patriciu Achimaş-Cadariu, Jindra Valentová, Mário Markuliak, Eva Fischer-Fodor |
| المصدر: |
Molecules; Volume 27; Issue 14; Pages: 4565 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
bisdemethoxycurcumin (BDMC), syringaldehyde curcumin, ruthenium(II) complexes, cytotoxicity, NF- κ B, FGF-2, MMP-9 |
| جغرافية الموضوع: |
agris |
| الوصف: |
So far, the polyphenolic components of turmeric have shown a significant pharmacological preventative activity for a wide spectrum of diseases, including oncological disorders. This type of natural product could be of great interest for the inhibition of cancer cell proliferation, displaying less side effects in comparison to classical chemotherapeutics. The poor bioavailability and quick metabolism of such natural compounds require new investigative methods to improve their stability in the organisms. A synthetic approach to increase the efficiency of curcuminoids is to coordinate them to metals through the beta-dicarbonyl moiety. We report the synthesis and the biological attempts on human ovarian carcinoma A2780 of ruthenium(II) complexes 1–4, containing curcuminoid ligands. The cytotoxicity of complexes 1–4 proves their antiproliferative capability, and a correlation between the IC50 values and NF-κB transcription factor, FGF-2, and MMP-9 levels was figured out through the principal component analysis (PCA). |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Medicinal Chemistry; https://dx.doi.org/10.3390/molecules27144565Test |
| DOI: |
10.3390/molecules27144565 |
| الإتاحة: |
https://doi.org/10.3390/molecules27144565Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.476E0913 |
| قاعدة البيانات: |
BASE |
