دورية أكاديمية
Chemical Site-Differentiation of Calix[4]arenes through Enforced Conformations by Confinement in a Cage
| العنوان: | Chemical Site-Differentiation of Calix[4]arenes through Enforced Conformations by Confinement in a Cage |
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| المؤلفون: | Kenta Iizuka, Hiroki Takezawa, Makoto Fujita |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Genetics, Biotechnology, Evolutionary Biology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, symmetric molecule within, lower symmetry abac, difficult synthetic strategy, symmetric molecules remains, stage functionalization, selectively activate, selective reactions, guest conformation, enforced conformations, coordination cage, controlled desymmetrization, cage desymmetrization |
| الوصف: | Desymmetrization of a symmetric skeleton enables late-stage functionalization of molecules. However, reagent-controlled desymmetrization by site-selective reactions of symmetric molecules remains a difficult synthetic strategy. Here, we found that complete confinement of a symmetric molecule within a coordination cage can desymmetrize the guest conformation, making it possible to site-selectively activate or protect the otherwise equivalent reaction sites of calix[4]arene derivatives. Multistep, one-cage reactions also demonstrated the transformation of an AAAA-type calix[4]arene into a lower symmetry ABAC-type one. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Chemical_Site-Differentiation_of_Calix_4_arenes_through_Enforced_Conformations_by_Confinement_in_a_Cage/24585204Test |
| DOI: | 10.1021/jacs.3c10720.s001 |
| الإتاحة: | https://doi.org/10.1021/jacs.3c10720.s001Test https://figshare.com/articles/journal_contribution/Chemical_Site-Differentiation_of_Calix_4_arenes_through_Enforced_Conformations_by_Confinement_in_a_Cage/24585204Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.2F00BFC3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/jacs.3c10720.s001 |
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