دورية أكاديمية
Targeting Sphingosine-1-Phosphate Signaling in Breast Cancer
| العنوان: | Targeting Sphingosine-1-Phosphate Signaling in Breast Cancer |
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| المؤلفون: | Masayuki Nagahashi, Yasuo Miyoshi |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 6, p 3354 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | sphinegosine-1-phosphate, breast cancer, microenvironment, lymphangiogenesis, lymphatic metastasis, targeted therapy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In recent years, newly emerging therapies, such as immune checkpoint inhibitors and antibody-drug conjugates, have further improved outcomes for breast cancer patients. However, recurrent and metastatic breast cancer often eventually develops resistance to these drugs, and cure is still rare. As such, the development of new therapies for refractory breast cancer that differ from conventional mechanisms of action is necessary. Sphingosine-1-phosphate (S1P) is a key molecule with a variety of bioactive activities, including involvement in cancer cell proliferation, invasion, and metastasis. S1P also contributes to the formation of the cancer microenvironment by inducing surrounding vascular- and lymph-angiogenesis and regulating the immune system. In this article, we outline the basic mechanism of action of S1P, summarize previous findings on the function of S1P in cancer cells and the cancer microenvironment, and discuss the clinical significance of S1P in breast cancer and the therapeutic potential of targeting S1P signaling. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/6/3354Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25063354 |
| الوصول الحر: | https://doaj.org/article/5b4c5585308f4e909a6e6768a69a5481Test |
| رقم الانضمام: | edsdoj.5b4c5585308f4e909a6e6768a69a5481 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25063354 |