دورية أكاديمية
Pathophysiological Implications of Interstitial Cajal-like Cells (ICC-like) in Uterus: A Comparative Study with Gastrointestinal ICCs
| العنوان: | Pathophysiological Implications of Interstitial Cajal-like Cells (ICC-like) in Uterus: A Comparative Study with Gastrointestinal ICCs |
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| المؤلفون: | Laura López-Pingarrón, Henrique Almeida, Desirée Pereboom-Maicas, Joaquín J. García |
| المصدر: | Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7557-7571 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | interstitial cells of Cajal, interstitial cells of Cajal-like cells, pacemaker, slow electrical waves, ultrastructure, immunohistochemistry, Biology (General), QH301-705.5 |
| الوصف: | The main function of interstitial cells of Cajal (ICCs) is to regulate gastrointestinal peristalsis by acting as a “pacemaker” cell by generating spontaneous slow electrical waves. In 2005, electron microscopy revealed a cell type similar to ICCs (ICC-like) outside the gastrointestinal tract, with contractile activity and c-Kit+ immunohistochemistry shared with ICCs. Among the locations where ICC-like cells have been observed, it is in the uterus where they have a significant functional and pathophysiological role. These cells are involved in obstetric phenomena of contractile action, such as ascending sperm transport, embryo implantation, pregnancy, delivery, and the expulsion of menstrual debris. Within the pathophysiology related to these cells, we find obstetric alterations such as recurrent miscarriages, premature deliveries, abolition of uterine contractions, and failures of embryo implantation, in addition to other common conditions in the fertile age, such as endometriosis and leiomyoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| العلاقة: | https://www.mdpi.com/1467-3045/45/9/476Test; https://doaj.org/toc/1467-3037Test; https://doaj.org/toc/1467-3045Test |
| DOI: | 10.3390/cimb45090476 |
| الوصول الحر: | https://doaj.org/article/3c674c59220f46329a72c3bcbc8ecd8eTest |
| رقم الانضمام: | edsdoj.3c674c59220f46329a72c3bcbc8ecd8e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb45090476 |