التفاصيل البيبلوغرافية
| العنوان: |
Design and characterization of an estradiol self-emulsifying drug delivery system (SEDDS) by pseudoternary phase diagrams and physicochemical tests ; Diseño y caracterización de un sistema de entrega de fármacos autoemulsificable (SEDDS) de estradiol por diagramas de fases pseudoternarios y pruebas fisicoquímicas ; Projeto e caracterização de um sistema de liberação de drogas autoemulsificante de estradiol (SEDDS) por meio de diagramas de fases pseudoternários e testes físico-químicos |
| المؤلفون: |
Goméz Palencia, Karolaine, Goméz de la Cruz, Laura, Herrera Marquéz, Alberto, Sotomayor, Reinaldo G. |
| المصدر: |
Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 51 No. 1 (2022) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 51 Núm. 1 (2022) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; v. 51 n. 1 (2022) ; 1909-6356 ; 0034-7418 |
| بيانات النشر: |
Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia |
| سنة النشر: |
2022 |
| المجموعة: |
Universidad Nacional de Colombia: Portal de Revistas UN |
| مصطلحات موضوعية: |
Estradiol, diagramas de fases, solubilidad, sistemas de entrega de fármacos autoemulsificables, phase diagrams, solubility, self-emulsifying drug delivery systems, solubilidade, sistemas de liberação de fármacos autoemulsificantes |
| الوصف: |
Introduction: Estradiol is a female sex steroid hormone widely used as hormonal therapy that has low bioavailability, due to its low aqueous solubility and high hydrophobicity, belonging to class II of the Biopharmaceutical Classification System. Aim:To design and characterize a self-emulsifying drug delivery system (SEDDS) for the drug estradiol by physicochemical tests to obtain the most optimal ratio that would improve its aqueous solubility, dissolution rate, and potentially its bioavailability. Method: Solubility studies in different solvents; pseudo ternary phase diagrams made up of oils, surfactants, co-surfactants, and water, allowed to recognize the different regions of SEDDS formation and identify the percentages of excipients that lead to the formation of isotropic solutions; The resulting formulations were characterized in autoemulsification time, robustness to dilution, cloud point and dissolution profile in a hard capsule. Results: The formulations containing Capmul MCM®, Kolliphor® RH40, and Transcutol®, had an autoemulsification time of approximately 1 minute; were stable at three different pHs (1.2, 4.5 and 7.2), at different dilution volumes, exhibiting a transparent, slightly bluish appearance, without precipitates, or phase separation, higher cloud points compared to the formulations containing Gelucire® 44/14. Conclusions: The characterization strategies used in the development of this research proved to be efficient for the adequate selection of excipients and their optimal ratio for the effective design of a self-emulsifying drug delivery system (SEDDS). ; Introdución: el estradiol es una hormona esteroide sexual femenina usada ampliamente como terapia hormonal que presenta una baja biodisponibilidad, debido asu baja solubilidad acuosa y a su alta hidrofobicidad, perteneciendo a la clase II del sistema de clasificación de biofarmacéutica. Objetivos: diseñar y caracterizar un sistema de entrega de fármacos autoemulsificable (SEDDS) para el fármaco estradiol por pruebas fisicoquímicas con el ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Spanish; Castilian |
| العلاقة: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/102729/83906Test; https://revistas.unal.edu.co/index.php/rccquifa/article/view/102729Test |
| الإتاحة: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/102729Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.30667259 |
| قاعدة البيانات: |
BASE |
