دورية أكاديمية
Late Thrombosis After Double Versus Single Drug-Eluting Stent in the Treatment of Coronary Bifurcations : a meta-analysis of randomized and observational Studies.
| العنوان: | Late Thrombosis After Double Versus Single Drug-Eluting Stent in the Treatment of Coronary Bifurcations : a meta-analysis of randomized and observational Studies. |
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| المؤلفون: | Marco Zimarino, CORAZZINI, ALESSANDRO, RICCI, FABRIZIO, DI NICOLA, MARTA, DE CATERINA, Raffaele |
| المساهمون: | Marco, Zimarino, Corazzini, Alessandro, Ricci, Fabrizio, DI NICOLA, Marta, DE CATERINA, Raffaele |
| سنة النشر: | 2013 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | CI, DDS, DES, MI, PCI, RCT, RR, SDS, TVR, confidence interval, coronary bifurcation, double drug-eluting stent strategy, drug-eluting stent thrombosi, drug-eluting stent(s), myocardial infarction, nROS, nonrandomized, observational study, percutaneous coronary intervention, randomized, controlled trial, relative risk, single drug-eluting stent strategy, target vessel revascularization |
| الوصف: | OBJECTIVES: This study sought to hypothesize that the higher risk of myocardial infarction (MI) documented after a routine double drug-eluting stent (DES) strategy (DDS) compared with a single DES strategy (SDS) with provisional stenting in percutaneous coronary interventions (PCI) of bifurcation lesions is driven by an increased rate of DES thrombosis. BACKGROUND: The results of currently available randomized, controlled trials (RCTs) were inconclusive in the choice between SDS and DDS. Meta-analyses have shown an increased risk of MI in the DDS group, without identifying the underlying mechanism(s). METHODS: We performed a meta-analysis of 12 major (>100 patients) studies of bifurcation DES PCI: 5 RCTs and 7 nonrandomized observational studies, for a total of 6,961 patients. Random-effects models were used to calculate summary risk ratios (RRs). As a primary endpoint, we assessed the RRs and 95% confidence intervals (CIs) of definite DES thrombosis; death, MI, and target vessel revascularization (TVR) were evaluated as secondary endpoints. RESULTS: Compared with SDS, DDS had an increased risk of DES thrombosis (RR: 2.31; 95% CI: 1.33 to 4.03) and MI (RR: 1.86; 95% CI: 1.34 to 2.60). Mortality (RR: 1.18; 95% CI: 0.85 to 1.65) and TVR (RR: 1.02; 95% CI: 0.80 to 1.30) were similar. The RRs of MI and DES thrombosis were associated (p = 0.040). CONCLUSIONS: In PCI of coronary bifurcations, SDS should be the preferred approach, as DDS is associated with an increased risk of MI, likely driven by DES thrombosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23769650; info:eu-repo/semantics/altIdentifier/wos/WOS:000322129400009; volume:6; issue:7; firstpage:687; lastpage:695; numberofpages:9; journal:JACC: CARDIOVASCULAR INTERVENTIONS; http://hdl.handle.net/11564/444485Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84880271031; https://www.sciencedirect.com/science/article/pii/S193687981300808XTest |
| DOI: | 10.1016/j.jcin.2013.03.012 |
| الإتاحة: | https://doi.org/10.1016/j.jcin.2013.03.012Test http://hdl.handle.net/11564/444485Test https://www.sciencedirect.com/science/article/pii/S193687981300808XTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.58DC185 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jcin.2013.03.012 |
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