المؤلفون: Gooding, Sarah, Whistler, Jennifer

مصطلحات موضوعية: G protein, arrestin, opioid, receptor trafficking, signaling bias, Humans, Analgesics, Opioid, Drug Tolerance, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8qw6g0ztTest

المؤلفون: Pinqi Wang, Arun Raja, Vincent B. Luscombe, Carole J. R. Bataille, Daniel Lucy, Vanessa V. Rogga, David R. Greaves, Angela J. Russell

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ox04529 ), enhanced, low picomolar values, >- oxide group, new gpr84 agonists, displayed excellent potency, coupled receptor 84, 69 , 68 , protein signaling bias, vivo <, n <, camp signaling, yielding compounds, rapidly metabolized, pharmacokinetic profile, hydroxy substituent, highly potent, high g, fibrotic diseases, biased agonist

العلاقة: https://figshare.com/articles/journal_contribution/Development_of_Highly_Potent_G_Protein_Pathway_Biased_Selective_and_Orally_Bioavailable_GPR84_Agonists/24903313Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00951.s001Test
https://figshare.com/articles/journal_contribution/Development_of_Highly_Potent_G_Protein_Pathway_Biased_Selective_and_Orally_Bioavailable_GPR84_Agonists/24903313Test

المؤلفون: Chen Zheng, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, Vsevolod V. Gurevich

المصدر: Cells; Volume 12; Issue 12; Pages: 1563

مصطلحات موضوعية: arrestin, GPCR, JNK3, conformation, signaling bias

وصف الملف: application/pdf

العلاقة: Cell Signaling; https://dx.doi.org/10.3390/cells12121563Test

الإتاحة: https://doi.org/10.3390/cells12121563Test

المؤلفون: Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7356

مصطلحات موضوعية: M1 muscarinic acetylcholine receptor, signaling bias, Gαq, β-arrestin, BRET, molecular docking

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Biology; https://dx.doi.org/10.3390/ijms24087356Test

الإتاحة: https://doi.org/10.3390/ijms24087356Test

المؤلفون: Bransom, Luke, Bassett, Ava P, Zhou, Mi, Cimino, Jack X, Mailman, Richard B, Yang, Yang

المصدر: Neuroscience ; ISSN:1873-7544 ; Volume:551

مصطلحات موضوعية: age-related cognitive decline, dopamine D1 agonist, functional selectivity/signaling bias, temporal order recognition, working memory

العلاقة: https://doi.org/10.1016/j.neuroscience.2024.05.033Test; https://pubmed.ncbi.nlm.nih.gov/38823551Test

الإتاحة: https://doi.org/10.1016/j.neuroscience.2024.05.033Test
https://pubmed.ncbi.nlm.nih.gov/38823551Test

المؤلفون: Fernández, Francisco J., Vega, María Cristina

المساهمون: Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, European Commission, Consejo Superior de Investigaciones Científicas (España), Fernández, Francisco J., Vega, María Cristina

مصطلحات موضوعية: GPCR receptors C5aR1 and C3aR, Agonist binding, Anaphylatoxins C5a and C3a, Receptor activation, Selectivity, Signaling bias

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; S2022/BMD-7278-COMPLEMENTO 3-CM; Postprint; https://doi.org/10.1016/j.tibs.2024.01.001Test; Sí; Trends in Biochemical Sciences S0968-0004(24)00001-X (2024); http://hdl.handle.net/10261/346466Test

الإتاحة: https://doi.org/10.1016/j.tibs.2024.01.001Test
http://hdl.handle.net/10261/346466Test

المؤلفون: Ian Winfield, Kerry Barkan, Sarah Routledge, Nathan J. Robertson, Matthew Harris, Ali Jazayeri, John Simms, Christopher A. Reynolds, David R. Poyner, Graham Ladds

المصدر: Frontiers in Endocrinology, Vol 12 (2022)

مصطلحات موضوعية: GPCRs, signaling bias, CLR, RAMPs, mutagenesis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2021.792912/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/52f71ab3e9e546068dc01614028b312bTest

المؤلفون: Adrian Morales-Pastor, Francho Nerín-Fonz, David Aranda-García, Miguel Dieguez-Eceolaza, Brian Medel-Lacruz, Mariona Torrens-Fontanals, Alejandro Peralta-García, Jana Selent

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7809

مصطلحات موضوعية: GPCR, signaling bias, functional selectivity, biased agonist, receptor dynamics, allosteric communication networks, molecular dynamics, network theory

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms23147809Test

الإتاحة: https://doi.org/10.3390/ijms23147809Test

المؤلفون: Declan M. Gorman (11681500), Xaria X. Li (11681503), John D. Lee (6445073), Jenny N. Fung (11681506), Cedric S. Cui (11681509), Han Siean Lee (8459298), Barbara E. Rolfe (4578907), Trent M. Woodruff (614066), Richard J. Clark (468092)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Physiology, Immunology, Developmental Biology, Cancer, Hematology, useful research tools, mediated calcium mobilization, complement peptide associated, none show selectivity, investigate c5ar1 function, c5a receptor function, fold selectivity, vivo activity, two gpcrs, signaling bias, selective agonists, related disorders, mouse model, mammary carcinoma, induces c5ar1, includes bm213, functionally similar, equal potency, c5a binds, arrestin recruitment, anaphylatoxin c5a

العلاقة: https://figshare.com/articles/journal_contribution/Development_of_Potent_and_Selective_Agonists_for_Complement_C5a_Receptor_1_with_In_Vivo_Activity/16990057Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01174.s001Test

المؤلفون: Alena Randáková, Dominik Nelic, Martina Hochmalová, Pavel Zimčík, Mutale Jane Mulenga, John Boulos, Jan Jakubík

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 18; Pages: 10089

مصطلحات موضوعية: muscarinic receptors, signaling bias, fusion proteins, non-canonical signaling

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Biochemistry; https://dx.doi.org/10.3390/ijms221810089Test

الإتاحة: https://doi.org/10.3390/ijms221810089Test