التفاصيل البيبلوغرافية
| العنوان: |
Effect of DNA Flexibility on Complex Formation of a Cationic Nanoparticle with Double-Stranded DNA |
| المؤلفون: |
Sehui Bae (11141646), Inrok Oh (11141649), Jejoong Yoo (1234710), Jun Soo Kim (1737499) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Biotechnology, Developmental Biology, Cancer, Space Science, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, persistence length, Martini coarse-grained models, charge, double-stranded DNA molecule, DNA flexibility, cationic nanoparticle increases, cationic nanoparticle, sequence-dependent DNA flexibility, double-stranded DNA molecules, 10 nm, DNA molecule bends |
| الوصف: |
We present extensive molecular dynamics simulations of a cationic nanoparticle and a double-stranded DNA molecule to discuss the effect of DNA flexibility on the complex formation of a cationic nanoparticle with double-stranded DNA. Martini coarse-grained models were employed to describe double-stranded DNA molecules with two different flexibilities and cationic nanoparticles with three different electric charges. As the electric charge of a cationic nanoparticle increases, the degree of DNA bending increases, eventually leading to the wrapping of DNA around the nanoparticle at high electric charges. However, a small increase in the persistence length of DNA by 10 nm requires a cationic nanoparticle with a markedly increased electric charge to bend and wrap DNA around. Thus, a more flexible DNA molecule bends and wraps around a cationic nanoparticle with an intermediate electric charge, whereas a less flexible DNA molecule binds to a nanoparticle with the same electric charge without notable bending. This work provides solid evidence that a small difference in DNA flexibility (as small as 10 nm in persistence length) has a substantial influence on the complex formation of DNA with proteins from a biological perspective and suggests that the variation of sequence-dependent DNA flexibility can be utilized in DNA nanotechnology as a new tool to manipulate the structure of DNA molecules mediated by nanoparticle binding. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Effect_of_DNA_Flexibility_on_Complex_Formation_of_a_Cationic_Nanoparticle_with_Double-Stranded_DNA/14991594Test |
| DOI: |
10.1021/acsomega.1c01709.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsomega.1c01709.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.1A984F32 |
| قاعدة البيانات: |
BASE |
