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1دورية أكاديمية
المؤلفون: Lorea Alejaldre (6204719), Claudèle Lemay-St-Denis (9461747), Joelle N. Pelletier (111656), Daniela Quaglia (3727315)
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, various mechanisms contribute, hydrolytic active site, fatty acid esters, epistatic interactions contribute, combining experimental determination, shorter chain length, different chain lengths, reshaping tunnel morphology, diverse selectivity profiles, bind substrates preferentially, tunnel stabilization, tunnel region, tuning selectivity, synthetic substrates, substitutions within, selective hydrolysis, protein dynamics, paramount importance, key substitutions, investigate variants, dynamic nature, distal regions
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2دورية أكاديمية
المؤلفون: Lu Xiao (314030), Linglan Fang (6692990), Sayantan Chatterjee (9753722), Eric T. Kool (1310808)
مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, employed deep sequencing, systematically varied structure, altered selectivity profiles, map rna structure, widely used, unpaired nucleotides, small enough, simplest reagent, selective reactions, selective labeling, rna library, reagent scaffold, protein contacts, paired ones, leaving open, improved conjugation, generally relying, conjugating rna, chiefly restricted, cell permeable
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3دورية أكاديمية
المؤلفون: Hao Xie (406287), Sheng Wang (339979), Yuquan Wang (129095), Peng Guo (134478), Xing-Zhong Shu (1586953)
مصطلحات موضوعية: Biochemistry, Medicine, Biotechnology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tolerates various functionalities, carbon quaternary centers, ar – sime, various vinyl halides, >- haloalkenes gives, tertiary alcohols metal, tertiary alcohols, trans <, synthetically appealing, synthetic community, selectivity profiles, reaction works, reaction proceeds, particular challenge, mild conditions, including fluorides, different classes, cis <, aryl electrophiles
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4دورية أكاديمية
المؤلفون: Nis Halland (1585213), Friedemann Schmidt (1693618), Tilo Weiss (1693615), Ziyu Li (534234), Jörg Czech (1585207), Joachim Saas (58827), Danping Ding-Pfennigdorff (1634593), Matthias K. Dreyer (1969390), Carsten Strübing (1693621), Marc Nazare (1634590)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, threonine kinase sgk1, druglike sgk1 inhibitor, based computer models, diseased osteoarthritic cartilage, novel hsgk1 co, rational compound design, 17a b, rational design, cartilage degradation, subchronic proof, selectivity profiles, powerful stimulator, potentially disease, oral dosing, oral disease, multiple ligand, modifying treatments, modifying agent, mechanism studies, highly potent
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5دورية أكاديمية
المؤلفون: Clément G.A. Morisse (11781337), Annelouise M. McCullagh (11781340), James W. Campbell (6734345), Colin How (11781343), Donald A. MacLaren (1343118), Robert H. Carr (1831813), Chris J. Mitchell (11781346), David Lennon (1831816)
مصطلحات موضوعية: Cell Biology, Evolutionary Biology, Ecology, Environmental Sciences not elsewhere classified, programmed infrared spectroscopy, enhanced heat transfer, enhance heat recovery, unit operation equipped, maximizes aniline selectivity, indicating aniline selectivity, compromise aniline selectivity, 2 sub, different pd loading, supported palladium catalysts, low loading catalyst, 3 sub, pd crystallite morphology, selectivity profiles, produce aniline, aniline yield, scale operation, 3 wt, two pd, pd crystallites, residence time, reference catalyst, reaction testing, overhydrogenated products, industrial specifications, elevated temperatures
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6دورية أكاديمية
المؤلفون: J. Willem M. Nissink (7424531), Sana Bazzaz (8932829), Carolyn Blackett (10270205), Matthew A. Clark (1370337), Olga Collingwood (10270208), Jeremy S. Disch (1960423), Diana Gikunju (8932826), Kristin Goldberg (1720258), John P. Guilinger (8932835), Elizabeth Hardaker (6158861), Edward J. Hennessy (1533484), Rachael Jetson (10270211), Anthony D. Keefe (3622769), William McCoull (1763365), Lindsay McMurray (2068162), Allison Olszewski (2671783), Ross Overman (1637866), Alexander Pflug (2885099), Marian Preston (3715579), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Paul Smith (175833), Caroline Truman (112220), Elizabeth Underwood (9210380), Juli Warwicker (10270214), Jon Winter-Holt (8775911), Simon Woodcock (3682174), Ying Zhang (40767)
مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, lead-generation campaign, HT, selectivity profiles, data mining, kinase binding, cancer progression, orthogonal high-throughput screenin., DNA-encoded chemical library, campaign strategy, Concurrent execution, DECL screening, Mer inhibitors, screening outcomes, Comprehensive Lead-Generation Strat., kinase family, drug resistance, tumor microenvironment, TAM family members
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7دورية أكاديمية
المؤلفون: Yasmin Shamsudin (14048672), Masoud Kazemi (1373493), Hugo Gutiérrez-de-Terán (1373487), Johan Åqvist (553577)
مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, results may facilitate, peptic ulcer formation, improved selectivity profiles, free energy simulations, bind significantly stronger, distinctly different ways, enigmatic stepwise tight, 16 different nsaids, two conformational substates, selective nsaids may, two enzyme conformations, new cox inhibitors, affinity tight binding, different classes, conformational changes, inhibitors affect, binding inhibitors, widely used, structural determinants, step manner, slowly reversible, side effects, selective high, respectively )
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8
المؤلفون: Matt Butzler, Laura Simdon, Cris Cowan, Jacquelyn Hennek, Hicham Zegzouti, Seth Hanson, Said A. Goueli, Tracy J Worzella
المصدر: Slas Technology
مصطلحات موضوعية: 0301 basic medicine, selectivity profiles, Computer science, Drug Evaluation, Preclinical, ADP detection, Computational biology, liquid handling, 01 natural sciences, Workflow, World Wide Web, 03 medical and health sciences, Original Reports, Profiling (information science), Bioluminescence, Enzyme Inhibitors, Automation, Laboratory, Drug discovery, Phosphotransferases, bioluminescence, 0104 chemical sciences, Computer Science Applications, 010404 medicinal & biomolecular chemistry, Medical Laboratory Technology, 030104 developmental biology, kinase profiling, Luminescent Measurements
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72d2cc9e9434e39b5c4218126f77019Test
http://europepmc.org/articles/PMC5418932Test -
9
المؤلفون: Miljković, Filip, Bajorath, Jürgen
المصدر: ACS Omega
مصطلحات موضوعية: Human kinome, multi-kinase inhibitors, selectivity, kinase-based selectivity profiles, compound-based selectivity profiles, compound data mining
العلاقة: https://zenodo.org/record/1148959Test; https://doi.org/10.5281/zenodo.1148959Test; oai:zenodo.org:1148959
الإتاحة: https://doi.org/10.5281/zenodo.1148959Test
https://doi.org/10.5281/zenodo.1148958Test
https://zenodo.org/record/1148959Test -
10
المؤلفون: Norrgard, Malena A., Mannervik, Bengt
المصدر: Journal of Molecular Biology. 412(1):111-120
مصطلحات موضوعية: catalytic promiscuity, substrate selectivity profiles, iterative saturation mutagenesis, indene 1, 2-oxide, active-site residue
وصف الملف: print