دورية أكاديمية
Inflammatory Bowel Disease Increases the Severity of Myocardial Infarction after Acute Ischemia–Reperfusion Injury in Mice
| العنوان: | Inflammatory Bowel Disease Increases the Severity of Myocardial Infarction after Acute Ischemia–Reperfusion Injury in Mice |
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| المؤلفون: | Mami, Wael, Znaidi-Marzouki, Soumaya, Doghri, Raoudha, Ben Ahmed, Melika, Znaidi, Sadri, Messadi, Erij |
| المساهمون: | University of Tunis El Manar, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity (BPF), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute Pasteur in Tunis Internal Collaborative Project ProgramPCI_22/2017 |
| المصدر: | ISSN: 2227-9059 ; Biomedicines ; https://hal.inrae.fr/hal-04583539Test ; Biomedicines, 2023, 11 (11), pp.2945. ⟨10.3390/biomedicines11112945⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | myocardial infarction, ischemia-reperfusion injury, inflammatory bowel disease, cytokine, sanimal model, translational medicine, cytokines, animal model, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| الوصف: | International audience ; (1) Background: Increased risk of myocardial infarction (MI) has been linked to several inflammatory conditions, including inflammatory bowel disease (IBD). However, the relationship between IBD and MI remains unclear. Here, we implemented an original mouse model combining IBD and MI to determine IBD’s impact on MI severity and the link between the two diseases. (2) Methods: An IBD model was established by dextran sulfate sodium (DSS) administration in drinking water, alone or with oral C. albicans (Ca) gavage. IBD severity was assessed by clinical/histological scores and intestinal/systemic inflammatory biomarker measurement. Mice were subjected to myocardial ischemia–reperfusion (IR), and MI severity was assessed by quantifying infarct size (IS) and serum cardiac troponin I (cTnI) levels. (3) Results: IBD mice exhibited elevated fecal lipocalin 2 (Lcn2) and IL-6 levels. DSS mice exhibited almost two-fold increase in IS compared to controls, with serum cTnI levels strongly correlated with IS. Ca inoculation tended to worsen DSS-induced systemic inflammation and IR injury, an observation which is not statistically significant. (4) Conclusions: This is the first proof-of-concept study demonstrating the impact of IBD on MI severity and suggesting mechanistic aspects involved in the IBD–MI connection. Our findings could pave the way for MI therapeutic approaches based on identified IBD-induced inflammatory mediators. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-01-108148-9 0-01-108148-1 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38001946; hal-04583539; https://hal.inrae.fr/hal-04583539Test; https://hal.inrae.fr/hal-04583539/documentTest; https://hal.inrae.fr/hal-04583539/file/2023_Mami_Biomedicines.pdfTest; PUBMED: 38001946; PUBMEDCENTRAL: PMC10669621; WOS: 001108148100001 |
| DOI: | 10.3390/biomedicines11112945 |
| الإتاحة: | https://doi.org/10.3390/biomedicines11112945Test https://hal.inrae.fr/hal-04583539Test https://hal.inrae.fr/hal-04583539/documentTest https://hal.inrae.fr/hal-04583539/file/2023_Mami_Biomedicines.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.89ADDC23 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780011081489 0011081481 |
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| DOI: | 10.3390/biomedicines11112945 |