دورية أكاديمية

Impact of Mineralocorticoid Receptor Gene NR3C2 on the Prediction of Functional Classification of Left Ventricular Remodeling and Arrhythmia after Acute Myocardial Infarction

التفاصيل البيبلوغرافية
العنوان: Impact of Mineralocorticoid Receptor Gene NR3C2 on the Prediction of Functional Classification of Left Ventricular Remodeling and Arrhythmia after Acute Myocardial Infarction
المؤلفون: Rima Braukyliene, Ali Aldujeli, Ayman Haq, Laurynas Maciulevicius, Darija Jankauskaite, Martynas Jurenas, Ramunas Unikas, Vytautas Zabiela, Vaiva Lesauskaite, Sandrita Simonyte, Diana Zaliaduonytė
المصدر: International Journal of Environmental Research and Public Health; Volume 20; Issue 1; Pages: 12
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2022
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: NR3C2 gene, acute myocardial infarction, mineralocorticoid receptor, rs5522, rs4635799, rs2070950
جغرافية الموضوع: agris
الوصف: Background: The NR3C2 gene encodes the mineralocorticoid receptor, which is present on cardiomyocytes. Prior studies reported an association between the presence of NR3C2 single-nucleotide polymorphisms (SNPs) and an increased cortisol production during a stress response such as acute myocardial infarction (AMI), which may lead to adverse cardiac remodeling. Objective: To study the impact of the NR3C2 rs2070950, rs4635799 and rs5522 gene polymorphisms on left ventricular (LV) remodeling, rhythm and conduction disorders in AMI patients. Methods: A cohort of 301 AMI patients who underwent revascularization was included. SNPs of the NR3C2 gene (rs2070950, rs4635799 and rs5522) were evaluated. A total of 127 AMI patients underwent transthoracic echocardiography follow-up after 72 h and 6 months. Results: The rs2070950 GG genotype and rs4635799 TT genotype were most common in patients who had LV end-diastolic volume increase < 20% and the same or increased LV ejection fraction, indicating a possible protective effect of these SNPs. The rs5522 TT genotype was associated with a higher frequency of arrhythmias, while the presence of at least one rs5522 C allele was associated with a lower risk of arrhythmias. Conclusion: SNPs of the NR3C2 gene appear to correlate with better ventricular remodeling and a reduced rate of arrhythmias post-AMI, possibly by limiting the deleterious effects of cortisol on cardiomyocytes.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
العلاقة: Global Health; https://dx.doi.org/10.3390/ijerph20010012Test
DOI: 10.3390/ijerph20010012
الإتاحة: https://doi.org/10.3390/ijerph20010012Test
حقوق: https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.29D7EACA
قاعدة البيانات: BASE