دورية أكاديمية
New Insights into the Molecular Structure of Tear Film Lipids Revealed by Surface X‑ray Scattering
| العنوان: | New Insights into the Molecular Structure of Tear Film Lipids Revealed by Surface X‑ray Scattering |
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| المؤلفون: | Ryan M. Trevorah, Mira Viljanen, Tuomo Viitaja, Henrik Stubb, Julia Sevón, Oleg Konovalov, Maciej Jankowski, Philippe Fontaine, Arnaud Hemmerle, Jan-Erik Raitanen, Filip S. Ekholm, Kirsi J. Svedström |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Medicine, Cell Biology, Biotechnology, Cancer, Computational Biology, Environmental Sciences not elsewhere classified, Physical Sciences not elsewhere classified, unique biological membrane, surface scattering methods, studying films formed, simulated physiological conditions, reveal quantitative data, principal lipid classes, ocular surface health, natural lipid composition, individual lipid classes, ray reflectivity studies, molecular tilt angles, functional roles played, grazing incidence x, ray diffraction, molecular structure, functional principle, pivotal role, overarching understanding, obtained previously, multilayer thickness, lattice distances |
| الوصف: | The tear film lipid layer (TFLL) is a unique biological membrane that serves a pivotal role in the maintenance of ocular surface health. Reaching an overarching understanding of the functional principle of the TFLL has been hampered by a lack of insights into the structural and functional roles played by individual lipid classes. To bridge this knowledge gap, we herein focus on studying films formed by principal lipid classes by surface scattering methods. Through grazing incidence X-ray diffraction and X-ray reflectivity studies, we reveal quantitative data about the lattice distances, molecular tilt angles, and mono/multilayer thickness and density profiles for central TFLL lipid classes under close to simulated physiological conditions. In addition, we discuss the correlation of the results to those obtained previously with the natural lipid composition of meibum. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/New_Insights_into_the_Molecular_Structure_of_Tear_Film_Lipids_Revealed_by_Surface_X_ray_Scattering/24936962Test |
| DOI: | 10.1021/acs.jpclett.3c02958.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.jpclett.3c02958.s001Test https://figshare.com/articles/journal_contribution/New_Insights_into_the_Molecular_Structure_of_Tear_Film_Lipids_Revealed_by_Surface_X_ray_Scattering/24936962Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.8ECB0C15 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jpclett.3c02958.s001 |
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