دورية أكاديمية
Performance of Panel-Estimated GFR Among Hospitalized Older Adults
| العنوان: | Performance of Panel-Estimated GFR Among Hospitalized Older Adults |
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| المؤلفون: | Iversen, Esben, Bengaard, Anne Kathrine, Leegaard Andersen, Aino, Tavenier, Juliette, Nielsen, Rikke Lundsgaard, Juul-Larsen, Helle Gybel, Jørgensen, Lillian Mørch, Bornæs, Olivia, Jawad, Baker Nawfal, Aharaz, Anissa, Walls, Anne Byriel, Kallemose, Thomas, Dalhoff, Kim, Nehlin, Jan Olof, Hornum, Mads, Feldt-Rasmussen, Bo, Damgaard, Morten, Andersen, Ove, Houlind, Morten Baltzer |
| المصدر: | Iversen , E , Bengaard , A K , Leegaard Andersen , A , Tavenier , J , Nielsen , R L , Juul-Larsen , H G , Jørgensen , L M , Bornæs , O , Jawad , B N , Aharaz , A , Walls , A B , Kallemose , T , Dalhoff , K , Nehlin , J O , Hornum , M , Feldt-Rasmussen , B , Damgaard , M , Andersen , O & Houlind , M B 2023 , ' Performance of Panel-Estimated GFR Among Hospitalized Older Adults ' , American Journal .... |
| سنة النشر: | 2023 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | creatinine, cystatin C, estimated glomerular filtration rate (eGFR), hospitalized older adults, renal risk medications, β-trace protein (BTP), β-Microglobulin (B2M) |
| الوصف: | Rationale & Objective: Older adults represent nearly half of all hospitalized patients and are vulnerable to inappropriate dosing of medications eliminated through the kidneys. However, few studies in this population have evaluated the performance of equations for estimating the glomerular filtration rate (GFR)—particularly those that incorporate multiple filtration markers. Study Design: Cross-sectional diagnostic test substudy of a randomized clinical trial. Setting & Participants: Adults ≥ 65 years of age presenting to the emergency department of Copenhagen University Hospital Amager and Hvidovre in Hvidovre, Denmark, between October 2018 and April 2021. Tests Compared: Measured GFR (mGFR) determined using 99mTc-DTPA plasma clearance compared with estimated GFR (eGFR) calculated using 6 different equations based on creatinine; 3 based on creatinine and cystatin C combined; and 2 based on panels of markers including creatinine, cystatin C, β-trace protein (BTP) and/or β 2 -microglobulin (B2M). Outcome: The performance of each eGFR equation compared with mGFR with respect to bias, relative bias, inaccuracy (1-P30), and root mean squared error (RMSE). Results: We assessed eGFR performance for 106 patients (58% female, median age 78.3 years, median mGFR 62.9 mL/min/1.73 m 2 ). Among the creatinine-based equations, the 2009 CKD-EPI cr equation yielded the smallest relative bias (+4.2%). Among the creatinine-cystatin C combination equations, the 2021 CKD-EPI comb equation yielded the smallest relative bias (−3.4%), inaccuracy (3.8%), and RMSE (0.139). Compared with the 2021 CKD-EPI comb , the CKD-EPI panel equation yielded a smaller RMSE (0.136) but larger relative bias (−4.0%) and inaccuracy (5.7%). Limitations: Only White patients were included; only a subset of patients from the original clinical trial underwent GFR measurement; and filtration marker concentration can be affected by subclinical changes in volume status. Conclusions: The 2009 CKD-EPI cr , 2021 CKD-EPI comb , and CKD-EPI panel equations ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1053/j.ajkd.2023.05.004 |
| الإتاحة: | https://doi.org/10.1053/j.ajkd.2023.05.004Test https://curis.ku.dk/portal/da/publications/performance-of-panelestimated-gfr-among-hospitalized-older-adultsTest(dc47f905-a26b-44f3-9de4-2bba3fc1c1e0).html https://curis.ku.dk/ws/files/375208601/1_s2.0_S0272638623007369.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.47931641 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1053/j.ajkd.2023.05.004 |
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