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1دورية أكاديمية
المصدر: Медицинская иммунология, Vol 26, Iss 2, Pp 401-406 (2024)
مصطلحات موضوعية: streptococcus pyogenes, experimental streptococcal infection, antimicrobial activity, immunotropic action, interleukins, pyrimidine derivative, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
العلاقة: https://www.mimmun.ru/mimmun/article/view/2705Test; https://doaj.org/toc/1563-0625Test; https://doaj.org/toc/2313-741XTest
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2دورية أكاديمية
المصدر: Carbon Resources Conversion, Vol 7, Iss 3, Pp 100222- (2024)
مصطلحات موضوعية: Pyrimidine derivative, Compounds, Binding energy, Active site, Antibacterial activity, Chemical technology, TP1-1185
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2588913324000115Test; https://doaj.org/toc/2588-9133Test
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3دورية أكاديمية
المؤلفون: Ying Li, Si-wei Song, Si-tong Chen, Kang-cai Wang, Qing-hua Zhang
المصدر: Energetic Materials Frontiers, Vol 4, Iss 1, Pp 16-23 (2023)
مصطلحات موضوعية: Energetic material, Pyrimidine derivative, Hydrogen bond, Low sensitivity, Detonation performance, Chemical technology, TP1-1185
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2666647223000076Test; https://doaj.org/toc/2666-6472Test
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4دورية أكاديمية
المؤلفون: Spasov, A. A., Fedorova, O. V., Rasputin, N. A., Ovchinnikova, I. G., Ishmetova, R. I., Ignatenko, N. K., Gorbunov, E. B., Sadykhov, G. A. O., Kucheryavenko, A. F., Gaidukova, K. A., Sirotenko, V. S., Rusinov, G. L., Verbitskiy, E. V., Charushin, V. N.
المصدر: International Journal of Molecular Sciences
مصطلحات موضوعية: 1,2,4-TRIAZOLO[5,1-C]TRIAZINES, ANTICOAGULANT, AZOLO[1,2,4,5]TETRAZINES, AZOLO[1,5-A]PYRIMIDINES, CYTOKINE STORM, INDOLO[2,3-B]QUINOXALINES, 2 CYCLOPENTYLTHIO 6 NITRO 7 METHOXY 4,7 DIHYDRO[1,5 A]PYRIMIDYL 4 GUANIDATE, 2 TRIFLUOROMETHYL 6 NITRO 7 METHOXY 4,7 DIHYDRO[1,5 A]PYRIMIDYL 4 GUANIDATE, 3 GUANIDINO 6 ALKYLTHIOIMIDAZO[1,2 B][1,2,4,5]TETRAZINE DERIVATIVE, 4 [7 (THIOPHEN 2 YL)[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5 YL]ANILINE, 4,4' (IMIDAZO[1,2 A]PYRIMIDINE 5,7 DIYL)DIANILINE, 4,5 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE DERIVATIVE, 6 GUANIDINO 3 ALKYLTHIO[1,2,4]TRIAZOLO[4,3 B][1,2,4,5]TETRAZINE DERIVATIVE, 6 GUANIDINO 3 CYCLOPENTYLTHIO[1,2,4]TRIAZOLO[4,3 B][1,2,4,5]TETRAZINE, 6 GUANIDINO 3 OCTYLTHIO[1,2,4]TRIAZOLO[4,3 B][1,2,4,5]TETRAZINE, 6 NITRO 7 HYDROXY 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 C ]TRIAZINYL 4 GUANIDATE, ANTICOAGULANT AGENT, ANTITHROMBIN, DABIGATRAN ETEXILATE, ECARIN, ETHYL 7 [3 (2 AMINOACETAMIDO)PHENYL] 5 METHYL 4,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 6 CARBOXYLATE, ETHYL 7 [4 (2 AMINOACETAMIDO)PHENYL] 5 METHYL 4,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 6 CARBOXYLATE, INDOLO[2,3 B]PYRAZINE DERIVATIVE, PYRIMIDINE DERIVATIVE, UNCLASSIFIED DRUG, ANTIDIABETIC AGENT, ANTIVIRUS AGENT, DABIGATRAN, ACTIVATED PARTIAL THROMBOPLASTIN TIME, ANIMAL EXPERIMENT
وصف الملف: application/pdf
العلاقة: Spasov, A, Fedorova, O, Rasputin, N, Ovchinnikova, I, Ishmetova, R, Ignatenko, N, Gorbunov, E, Sadykhov, G, Kucheryavenko, A, Gaidukova, K, Sirotenko, VS, Rusinov, GL, Verbitskiy, E & Charushin, V 2023, 'Novel Substituted Azoloazines with Anticoagulant Activity', International Journal of Molecular Sciences, Том. 24, № 21, 15581. https://doi.org/10.3390/ijms242115581Test; Spasov, A., Fedorova, O., Rasputin, N., Ovchinnikova, I., Ishmetova, R., Ignatenko, N., Gorbunov, E., Sadykhov, G., Kucheryavenko, A., Gaidukova, K., Sirotenko, V. S., Rusinov, G. L., Verbitskiy, E., & Charushin, V. (2023). Novel Substituted Azoloazines with Anticoagulant Activity. International Journal of Molecular Sciences, 24(21), [15581]. https://doi.org/10.3390/ijms242115581Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176322723&doi=10.3390%2fijms242115581&partnerID=40&md5=57c29372a6ef5a898df667f5a2fd5e50Test; https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588Test; http://elar.urfu.ru/handle/10995/130943Test; 85176322723
الإتاحة: https://doi.org/10.3390/ijms242115581Test
http://elar.urfu.ru/handle/10995/130943Test
https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588Test -
5
المؤلفون: Wan, Yi-Hong, Nandakumar, Kutty Selva, 1965
المصدر: Acta Pharmacologica Sinica. 41(5):706-718
مصطلحات موضوعية: Dengue virus, JAK/STAT signaling pathway, RdRp inhibitor, [1, 4]triazolo[1, 5-a]pyrimidine derivative, antiviral agent, inflammation
وصف الملف: electronic
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48357Test
https://doi.org/10.1038/s41401-019-0316-7Test
https://hh.diva-portal.org/smash/get/diva2:1702772/FULLTEXT01.pdfTest -
6
المؤلفون: Zeng, S., Dou, W., Li, M., Zhou, Yang, 1989, Guo, J., Zhao, N., Huang, H., Zhou, Q., Hu, W., Ma, Y., Zhao, X., Xie, H.
المصدر: ChemMedChem. 15(16):1608-1617
مصطلحات موضوعية: biostability, DPP-IV, in silico testing, inhibitors, metabolism, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (1h pyrazol 4 yl)thieno[3, 2 d]pyrimidin 3(4h) yl]methyl] 4 fluorobenzonitrile, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 (pyridin 4 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 6 [3 (trifluoromethyl)phenyl]thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxo 7 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (2 methoxypyridin 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (2 methylpyridin 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (3 fluorophenyl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (3, 5 dimethylisoxazol 4 yl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 (4 fluorophenyl) 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 bromo 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 6 [3 (methylsulfonyl)phenyl] 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 bromo 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 fluoro 4 oxothieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 methyl 4 oxo 6 (pyridin 3 yl)thieno[3, 2 [[2 (3 aminopiperidin 1 yl) 7 methyl 4 oxothieno[3, antidiabetic agent, cytochrome P450, dipeptidyl peptidase IV inhibitor, long acting drug, pyrimidine derivative, trelagliptin, unclassified drug, xanthine derivative, animal experiment, area under the curve, Article, computer model, controlled study, drug bioavailability, drug design, drug efficacy, drug half life, drug potency, drug transformation, glycemic control, IC50, in vitro study, in vivo study, infant, male, maximum plasma concentration, mean residence time, metabolic stability, nonhuman, priority journal, rat, time to maximum plasma concentration
وصف الملف: print
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-286487Test
https://doi.org/10.1002/cmdc.202000175Test -
7دورية أكاديمية
المؤلفون: Spasov, A., Ovchinnikova, I., Fedorova, O., Titova, Y., Babkov, D., Kosolapov, V., Borisov, A., Sokolova, E., Klochkov, V., Skripka, M., Velikorodnaya, Y., Smirnov, A., Rusinov, G., Charushin, V.
المصدر: Molecules
مصطلحات موضوعية: CYTOKINE RELEASE, INFLAMMATION, LUNG INJURY, PYRIMIDINES, [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINES, INTERLEUKIN 6, LIPOPOLYSACCHARIDE, PROTECTIVE AGENT, PYRIMIDINE DERIVATIVE, ACUTE LUNG INJURY, ANIMAL, CHEMISTRY, LUNG, MOUSE, ANIMALS, INTERLEUKIN-6, LIPOPOLYSACCHARIDES, MICE, PROTECTIVE AGENTS
وصف الملف: application/pdf
العلاقة: Spasov, A, Ovchinnikova, I, Fedorova, OV, Titova, Y, Babkov, D, Kosolapov, V, Borisov, A, Sokolova, E, Klochkov, V, Skripka, M, Velikorodnaya, Y, Smirnov, A, Rusinov, G & Charushin, V 2023, 'Amino Derivatives of Diaryl Pyrimidines and Azolopyrimidines as Protective Agents against LPS-Induced Acute Lung Injury', Molecules, Том. 28, № 2, 741. https://doi.org/10.3390/molecules28020741Test; Spasov, A., Ovchinnikova, I., Fedorova, O. V., Titova, Y., Babkov, D., Kosolapov, V., Borisov, A., Sokolova, E., Klochkov, V., Skripka, M., Velikorodnaya, Y., Smirnov, A., Rusinov, G., & Charushin, V. (2023). Amino Derivatives of Diaryl Pyrimidines and Azolopyrimidines as Protective Agents against LPS-Induced Acute Lung Injury. Molecules, 28(2), [741]. https://doi.org/10.3390/molecules28020741Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146661927&doi=10.3390%2fmolecules28020741&partnerID=40&md5=70b72ca2016b949c44f0ccc9a7e1a1deTest; https://www.mdpi.com/1420-3049/28/2/741/pdf?version=1674033724Test; http://elar.urfu.ru/handle/10995/130859Test; 85146661927; 000918798700001
الإتاحة: https://doi.org/10.3390/molecules28020741Test
http://elar.urfu.ru/handle/10995/130859Test
https://www.mdpi.com/1420-3049/28/2/741/pdf?version=1674033724Test -
8دورية أكاديمية
المؤلفون: Ying-Zhe Wang, Hong-Yu Li, Yan Zhang, Rui-Xin Jiang, Jun Xu, Jing Gu, Zheng Jiang, Zheng-Yu Jiang, Qi-Dong You, Xiao-Ke Guo
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Infectious Diseases, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, various human cancers, regulating rna processing, favorable safety profile, could selectively inhibit, based virtual screening, >] pyrimidine derivative, alkb homologue 5, alkbh5 targeting therapies, ii )/ 2, 6 , 2728 , selective alkbh5 inhibitor, selective inhibitor, 5 ‑<, selective probe, tacc3 <, n <, significant role
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01374.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Pyrazolo_1_5_i_a_i_pyrimidine_Derivative_as_a_Novel_and_Selective_ALKBH5_Inhibitor_for_the_Treatment_of_AML/24595766Test -
9دورية أكاديمية
المؤلفون: Hıncal, H.O., Aslan, N.A., Elver, Ö., Erol, V., Güler, N.
مصطلحات موضوعية: adenosine deaminase, adult, Bosutinib, pleural effusion, cross-intolerance, chronic myeloid leukemia, C reactive protein, creatinine, dasatinib, furosemide, hemoglobin, imatinib, nilotinib, prednisolone, protein kinase inhibitor, protein tyrosine kinase inhibitor, pyrimidine derivative, absolute neutrophil count, Article, cancer chemotherapy, case report, catheter removal, clinical article, corticosteroid therapy, diuretic therapy, drug dose reduction, drug hypersensitivity, drug induced disease, drug substitution, drug withdrawal
العلاقة: Journal of Oncology Pharmacy Practice; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/52846Test; https://doi.org/10.1177/10781552221114070Test; 29; 511; 516; 2-s2.0-85134254623
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10دورية أكاديمية
المؤلفون: A. A. Tsibizova, A. L. Yasenyavskaya, I. N. Tyurenkov, A. A. Ozerov, M. A. Samotrueva, А. А. Цибизова, А. Л. Ясенявская, И. Н. Тюренков, А. А. Озеров, М. А. Самотруева
المساهمون: Работа выполнена в рамках государственного задания Министерства здравоохранения Российской Федерации в части проведения НИР по теме «Поиск и разработка перспективных соединений с антибактериальной активностью среди производных пиримидина для создания лекарственных препаратов» 48.2-2021.
المصدر: Medical Immunology (Russia); Том 26, № 2 (2024); 401-406 ; Медицинская иммунология; Том 26, № 2 (2024); 401-406 ; 2313-741X ; 1563-0625
مصطلحات موضوعية: производное пиримидина, experimental streptococcal infection, antimicrobial activity, immunotropic action, interleukins, pyrimidine derivative, экспериментальная стрептококковая инфекция, противомикробная активность, иммунотропное действие, интерлейкины
وصف الملف: application/pdf
العلاقة: https://www.mimmun.ru/mimmun/article/view/2705/1913Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11065Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11066Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11067Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11068Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11069Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11070Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11071Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11315Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11316Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11317Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/11318Test; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2705/12687Test; Бурова Л.А., Суворов А.Н., Тотолян А.А. Streptococcus pyogenes: феномен неиммунного связывания иммуноглобулинов человека и его роль в патологии // Медицинская иммунология, 2022. Т. 24, № 2. С. 217-234. doi:10.15789/1563-0625-SPP-2450.; Бурова Л.А., Тотолян А.А. Основные факторы патогенности Streptococcus pyogenes // Инфекция и иммунитет, 2022. Т. 12, № 1. С. 33-50. doi:10.15789/2220-7619-MPF-1723.; Коваленко Л.П., Никитин С.В., Кузнецова О.С., Журиков Р.В., Сорокина А.В., Мирошкина И.А., Коржова К.В. Изучение противовоспалительных, иммуномодулирующих и противоопухолевых свойств СНК-411 // Экспериментальная и клиническая фармакология, 2018. Т. 81, № S. С. 115.; Красницкая А.С., Бочарова О.С., Первов Ю.Ю., Климкина Т.Н. Характеристика местного цитокинового профиля у больных хроническим тонзиллитом в зависимости от этиологии // Российский иммунологический журнал, 2019. T. 22, № 2-1. С. 338-340. doi:10.31857/S102872210006620-7.; Нурбоев Х.И. Производные пиримидина и их применение в медицине // Boshqaruv va etika qoidalari onlayn ilmiy jurnali, 2022. T. 2, № 4. С. 32-35.; Фрейдлин И.С., Старикова Э.А., Лебедева А.М. Преодоление защитных функций макрофагов факторами вирулентности Streptococcus pyogenes // Бюллетень сибирской медицины, 2019. T. 18, № 1.C. 109-118.; Цибизова А.А., Тюренков И.Н., Озеров А.А., Башкина О.А., Самотруева М.А. Регуляторное влияние производного хиназолина с альфа-нафтильным радикалом на уровень TNF-α, IL-6 и IL-10 в условиях экспериментальной генерализованной инфекции // Астраханский медицинский журнал, 2020. Т. 15, № 4. C. 97-107.; Цибизова А.А., Ясенявская А.Л., Озеров А.А., Самотруева М.А., Тюренков, И.Н. Оценка острой токсичности нового пиримидинового производного // Астраханский медицинский журнал, 2021. Т. 16, № 1. С. 82-87.; Чиряпкин А.С. Обзор производных пиримидина как фармакологически активных соединений // Juvenis Scientia, 2022. T. 8, № 5. С. 16-30.; Anderson D., Imran S., Frost H.R., Azzopardi K.I., Jalali S., Novakovich B., Pellicci D.G. The immune signature of acute pharyngitis in the study of Streptococcus pyogenes in humans. Nat. Commun., 2022, Vol. 13, no. 1, 769. doi:10.1038/s41467-022-28335-3.; Avire N.J., While H., Ross K. Review of Streptococcus pyogenes: public health risk factors, prevention and control. Pathogens, 2021, Vol. 10, no. 2, 248. doi:10.3390/pathogens10020248.; Gonzales A.J., Bowman J.W., Fici G.J., Zhang M., Mann D.W., Mitton-Fry M. Oclacitinib (APOQUEL(®)) is a novel janus kinase inhibitor with activity against cytokines involved in allergy. J. Vet. Pharmacol. Ther., 2014, Vol. 37, no. 4, pp. 317-324.; Morelli M., Scarponi C., Mercurio L., Facchiano F., Pallotta S., Madonna S., Girolomoni G., Albanesi C. Selective immunomodulation of inflammatory pathways in keratinocytes by the janus kinase(JAK) inhibitor tofacitinib: implications for the employment of JAK-targeting drugs in psoriasis. J. Immunol. Res., 2018, Vol. 2018, 7897263. doi:10.1155/2018/7897263.; Rath E., Palma Medina L.M., Jahagirdar S., Mosevoll K.A., Damås J.K., Madsen M.B., Svensson M., Hyldegaard O., Martins Dos Santos V.A.P.; INFECT Study group; Saccenti E., Norrby-Teglund A., Skrede S., Bruun T. Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study. Clin. Immunol., 2023, Vol. 249, no. 9, 109276. doi:10.1016/j.clim.2023.109276.; Singh S.B., Young K., Silver L.L. What is an “ideal” antibiotic? Challenges of discovery and the way forward. Biochem. Pharmacol., 2017, no. 133, pp. 63-73.; Yılmaz Ç., Özcengiz G. Antibiotics: Pharmacokinetics, toxicity, resistance and multi-drug efflux pumps. Biochem. Pharmacol., 2017, no. 133, pp. 43-62.; https://www.mimmun.ru/mimmun/article/view/2705Test
الإتاحة: https://doi.org/10.15789/1563-0625-EOA-2705Test
https://doi.org/10.15789/1563-0625-SPP-2450Test
https://doi.org/10.15789/2220-7619-MPF-1723Test
https://doi.org/10.31857/S102872210006620-7Test
https://doi.org/10.1038/s41467-022-28335-3Test
https://doi.org/10.3390/pathogens10020248Test
https://doi.org/10.1155/2018/7897263Test
https://doi.org/10.1016/j.clim.2023.109276Test
https://www.mimmun.ru/mimmun/article/view/2705Test
النص الكامل