دورية أكاديمية
Piperine Attenuates Bmal1 -Mediated Glucose Metabolism Disorder in a Trpv1 -Dependent Manner in HepG2 Cells
| العنوان: | Piperine Attenuates Bmal1 -Mediated Glucose Metabolism Disorder in a Trpv1 -Dependent Manner in HepG2 Cells |
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| المؤلفون: | Jiayi Sun, Biqi Tang, Chi-Tang Ho, Muwen Lu |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Cancer, Mental Health, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, various pharmacological effects, resistant cell model, pungent alkaloid found, >- dependent manner, 98 ± 5, 76 ± 4, 47 ± 3, 43 ± 3, 36 ± 6, 19 ± 1, mitigated circadian disruption, hepg2 cells via, hepg2 cells piperine, circadian clock gene, pip alleviated glucosamine, hepg2 cells, circadian misalignment, piperine attenuates, pip alleviated |
| الوصف: | Piperine (PIP), a pungent alkaloid found in black pepper, has various pharmacological effects by activating the transient receptor potential vanilloid 1 (TRPV1) receptor. In this study, the regulating effect of PIP on glucose metabolism and the underlying mechanism were examined using an insulin-resistant cell model. Results showed that PIP alleviated glucosamine (GlcN)-induced glucose metabolism disorder (from 59.19 ± 1.90 to 88.36 ± 6.57%), restored cellular redox balance (from 148.43 ± 3.52 to 110.47 ± 3.52%), improved mitochondrial function (from 63.76 ± 4.87 to 85.98 ± 5.12%), and mitigated circadian disruption in HepG2 cells via the mediation of circadian clock gene Bmal1 . After the knockdown of the Trpv1 gene, the modulating effect of PIP on Bmal1 -mediated glucose metabolism was weakened, indicating that PIP alleviated Bmal1 -involved insulin resistance and circadian misalignment in a Trpv1 -dependent manner in HepG2 cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Piperine_Attenuates_i_Bmal1_i_-Mediated_Glucose_Metabolism_Disorder_in_a_i_Trpv1_i_-Dependent_Manner_in_HepG2_Cells/24711709Test |
| DOI: | 10.1021/acs.jafc.3c06683.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.jafc.3c06683.s001Test https://figshare.com/articles/journal_contribution/Piperine_Attenuates_i_Bmal1_i_-Mediated_Glucose_Metabolism_Disorder_in_a_i_Trpv1_i_-Dependent_Manner_in_HepG2_Cells/24711709Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.98C055B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jafc.3c06683.s001 |
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