المؤلفون: Yuanyuan Jia, Yuhui Yao, Lingyao Fan, Qiqing Huang, Guohao Wei, Peiliang Shen, Jia Sun, Gaoshuang Zhu, Zhaorui Sun, Chuandong Zhu, Xin Han

المصدر: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Doxorubicin (DOX), Isoliquiritigenin (ISL), CRISPR-Cas 9, Protein tyrosine phosphatase non-receptor type 2 (PTPN2), Immunotherapy, Synergistic therapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1477-3155Test

الوصول الحر: https://doaj.org/article/7a6103de8d214d88bda12105e3dddc0bTest

المؤلفون: Ellegård, Sander, 1985

المساهمون: Stål, Olle, Professor, 1952, Elander, Nils, Associate Professor, 1980, Hallbeck, Anna-Lotta, PhD, 1967, Foukakis, Theodoros, Associate Professor

المصدر: Linköping University Medical Dissertations.

مصطلحات موضوعية: HER2 amplification, PTPN2, Implementation, sTILs, Brain metastasis

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203226Test
https://doi.org/10.3384/9789180756242Test
https://liu.diva-portal.org/smash/get/diva2:1856153/FULLTEXT01.pdfTest
https://liu.diva-portal.org/smash/get/diva2:1856153/PREVIEW01.pngTest

المؤلفون: Luis Alberto Perez-Quintero, Belma Melda Abidin, Michel L. Tremblay

المصدر: Frontiers in Medicine, Vol 11 (2024)

مصطلحات موضوعية: protein tyrosine phosphatases, T cells, immunotherapy, signaling, PTP1B (PTPN1), TCPTP (PTPN2), Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2024.1364778/fullTest; https://doaj.org/toc/2296-858XTest

الوصول الحر: https://doaj.org/article/00e8f967a7a54fcdabfb4d7e0f1364e3Test

المؤلفون: Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: cardiovascular disease, atherosclerosis, PTPN2, inflammatory response, inflammatory cytokines, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1219690/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/0daa4d9c863f445aae8fe804f87c5cf9Test

المؤلفون: Yapeng Liu, Lu Han, Ping Zhu, Ming Song, Yaoyuan Zhang, Linlin Meng, Wei Zhang, Cheng Zhang, Ming Zhong

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: PTPN2, TAK1, adipocytes, senescence, adipose tissue browning, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1124633/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/73f5adecb8c04d98b533cd0a87a62a55Test

المؤلفون: Xiaolong Tang, Xue Sui, Yongshuo Liu

المصدر: Heliyon, Vol 9, Iss 1, Pp e12873- (2023)

مصطلحات موضوعية: PTPN2, Pan-cancer, Prognosis, Immunotherapy, Biomarker, Science (General), Q1-390, Social sciences (General), H1-99

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844023000804Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/bbb70248c5a248cca5c5fcba2ffcb28aTest

المؤلفون: Ivana Samaržija, Paško Konjevoda

المصدر: Biomedicines; Volume 11; Issue 7; Pages: 2006

مصطلحات موضوعية: prostate cancer, extracellular matrix, integrin adhesion complex, cancer prognosis, progression-free survival, recursive partitioning, Gleason score, FMOD, PTPN2

وصف الملف: application/pdf

العلاقة: Cell Biology and Pathology; https://dx.doi.org/10.3390/biomedicines11072006Test

الإتاحة: https://doi.org/10.3390/biomedicines11072006Test

المؤلفون: Dohee Ahn, Jihee Kwon, Songyi Song, Jooyoung Lee, Sunyoung Yoon, Sang J. Chung

المصدر: Life; Volume 13; Issue 6; Pages: 1372

مصطلحات موضوعية: protein tyrosine phosphatases (PTPs), PTPN2, PTPN6, methyl syringate, catalytic activity, type 2 diabetes, glucose uptake

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Pharmaceutical Science; https://dx.doi.org/10.3390/life13061372Test

الإتاحة: https://doi.org/10.3390/life13061372Test

المؤلفون: N. V. Nikitchenko, H. A. Yatskiu, E. S. Siniauskaya, H. G. Bialkevich, I. A. Kazyra, N. Yu. Dostanko, V. E. Yagur, R. I. Goncharova, Н. В. Никитченко, А. А. Яцкив, Е. С. Синявская, А. Г. Белькевич, И. А. Козыро, Н. Ю. Достанко, В. Е. Ягур, Р. И. Гончарова

المصدر: Doklady of the National Academy of Sciences of Belarus; Том 67, № 3 (2023); 222-230 ; Доклады Национальной академии наук Беларуси; Том 67, № 3 (2023); 222-230 ; 2524-2431 ; 1561-8323 ; 10.29235/1561-8323-2023-67-3

مصطلحات موضوعية: PTPN22, lupus nephritis, STAT4, PTPN2, люпус нефрит

وصف الملف: application/pdf

العلاقة: https://doklady.belnauka.by/jour/article/view/1132/1131Test; Козыро, И. А. Системная красная волчанка с поражением почек у детей / И. А. Козыро, А. В. Сукало. – Минск, 2021. – 214 c.; Первичная и общая заболеваемость ревматоидным артритом и системными заболеваниями соединительной ткани среди взрослых в г. Минске по данным официальной статистики за 2001–2005 годы / В. Е. Ягур [и др.] // Здравоохранение. – 2009. – № 2. – С. 39–42.; Mohan, C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis / C. Mohan, C. Putterman // Nature Reviews Nephrology. – 2015. – Vol. 11, N 6. – P. 329–341. https://doi.org/10.1038/nrneph.2015.33Test; JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation / K. Ikeda [et al.] // BMC Immunol. – 2017. – Vol. 18, N 1. – Art. 41. https://doi.org/10.1186/s12865-017-0225-9Test; Yamamoto, K. Shared genetic factors and their causality in autoimmune diseases / K. Yamamoto, Y. Okada // Annals of the Rheumatic Diseases. – 2019. – Vol. 78, N 11. – P. 1449–1451. https://doi.org/10.1136/annrheumdis-2019-215099Test; Полиморфизм генов иммунного и воспалительного ответа у детей с суставным синдромом / А. А. Яцкив [и др.] // Молекулярная и прикладная генетика. – Минск, 2019. – Т. 27. – С. 5–16.; Полиморфизм генов STAT4, PD-1, PD-L1 у детей, страдающих системной красной волчанкой и люпус нефритом / Е. С. Синявская [и др.] // Молекулярная и прикладная генетика. – Минск, 2019. – Т. 27. – С. 25–32.; Wang, J.-M. Association of STAT4 gene rs7574865, rs10168266 polymorphisms and systemic lupus erythematosus susceptibility: A meta-analysis / J.-M. Wang, W.-D. Xu, an-F. Huang // Immunological Investigations. – 2021. – Vol. 50, N 2–3. – P. 282–294. https://doi.org/10.1080/08820139.2020.1752712Test; STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk / A. K. Abelson [et al.] // Annals of the Rheumatic Diseases. – 2009. – Vol. 68, N 11. – P. 1746–1753. https://doi.org/10.1136/ard.2008.097642Test; Hagberg, N. Immunogenetics in Systemic Lupus Erythematosus: Transitioning from Genetic Associations to Cellular Effects / N. Hagberg, C. Lundtoft, L. Rönnblom // Scandinavian Journal of Immunology. – 2020. – Vol. 92, N 4. – Art. e12894. https://doi.org/10.1111/sji.12894Test; High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups / B. Namjou [et al.] // Arthritis Rheum. – 2009. – Vol. 60, N 4. – P. 1085–1095. https://doi.org/10.1002/art.24387Test; Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus / K. E. Taylor [et al.] // PLoS Genetics. – 2008. – Vol. 4, N 5. – Art. e1000084. https://doi.org/10.1371/journal.pgen.1000084Test; Chistiakov, D. A. T-cell protein tyrosine phosphatase: a role in inflammation and autoimmunity / D. A. Chistiakov, E. I. Chistiakova // Int. J. Diabetes Mellit. – 2010. – Vol. 2, N 2. – P. 114–118. https://doi.org/10.1016/j.ijdm.2010.05.012Test; A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene / C. Ciccacci [et al.] // PLoS One. – 2014. – Vol. 9, N 11. – Art. e111991. https://doi.org/10.1371/journal.pone.0111991Test; Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls / WTCCC (Welcome Trust Case Control Consortium) // Nature. – 2007. – Vol. 447. – P. 661–678.; Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis / L. Y. Hu [et al.] // Arch. Dermatol. Res. – 2017. – Vol. 309, N 6. – P. 461–477. https://doi.org/10.1007/s00403-017-1745-0Test; AB0016 Genetic variants of predisposition to rheumatoid arthritis in Belarusian population [EULAR Annual Congress, Copenhagen, June 1–4, 2022] / E. Siniauskaya [et al.] // Ann. Rheum. Dis. – 2022. – Vol. 81, N 1. – Art. 1143. https://doi.org/10.1136/annrheumdis-2022-eular.4519Test; https://doklady.belnauka.by/jour/article/view/1132Test

الإتاحة: https://doi.org/10.29235/1561-8323-2023-67-3-222-230Test
https://doi.org/10.29235/1561-8323-2023-67-3Test
https://doi.org/10.1038/nrneph.2015.33Test
https://doi.org/10.1186/s12865-017-0225-9Test
https://doi.org/10.1136/annrheumdis-2019-215099Test
https://doi.org/10.1080/08820139.2020.1752712Test
https://doi.org/10.1136/ard.2008.097642Test
https://doi.org/10.1111/sji.12894Test
https://doi.org/10.1002/art.24387Test
https://doi.org/10.1371/journal.pgen.1000084Test

المؤلفون: Niechcial, Anna, Schwarzfischer, Marlene, Wawrzyniak, Marcin, Atrott, Kirstin, Laimbacher, Andrea, Morsy, Yasser, Katkeviciutė, Egle, Häfliger, Janine, Westermann, Patrick, Akdis, Cezmi A, Scharl, Michael, Spalinger, Marianne R

المصدر: Niechcial, Anna; Schwarzfischer, Marlene; Wawrzyniak, Marcin; Atrott, Kirstin; Laimbacher, Andrea; Morsy, Yasser; Katkeviciutė, Egle; Häfliger, Janine; Westermann, Patrick; Akdis, Cezmi A; Scharl, Michael; Spalinger, Marianne R (2023). Spermidine ameliorates colitis via induction of anti-inflammatory macrophages and prevention of intestinal dysbiosis. Journal of Crohn's & Colitis, 17(9):1489-1503.

مصطلحات موضوعية: Clinic for Gastroenterology and Hepatology, Swiss Institute of Allergy and Asthma Research, 610 Medicine & health, IBD, PTPN2, Spermidine, anti-inflammatory macrophages, dysbiosis

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/235155/1/ZORA_235155.pdfTest; info:pmid/36995738; urn:issn:1873-9946

الإتاحة: https://doi.org/10.5167/uzh-23515510.1093/ecco-jcc/jjad058Test
https://www.zora.uzh.ch/id/eprint/235155Test/
https://www.zora.uzh.ch/id/eprint/235155/1/ZORA_235155.pdfTest