The Multifaceted Roles of Proline in Cell Behavior
| العنوان: | The Multifaceted Roles of Proline in Cell Behavior |
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| المؤلفون: | Annalisa Fico, Dario De Cesare, Federica Cermola, Eduardo J. Patriarca, Gabriella Minchiotti, Ombretta Guardiola, Cristina D'Aniello |
| المصدر: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology 9 (2021). doi:10.3389/fcell.2021.728576 info:cnr-pdr/source/autori:Patriarca E.J.; Cermola F.; D'Aniello C.; Fico A.; Guardiola O.; De Cesare D.; Minchiotti G./titolo:The Multifaceted Roles of Proline in Cell Behavior/doi:10.3389%2Ffcell.2021.728576/rivista:Frontiers in Cell and Developmental Biology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:9 Frontiers in Cell and Developmental Biology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | genetic structures, QH301-705.5, Antimicrobial peptides, energy source, Review, Cell morphology, behavioral disciplines and activities, antistress activity, signaling modulators, neural toxicity, Cell and Developmental Biology, proline metabolism, extracellular proteins, Extracellular, Biology (General), proline metabolismcell plasticityextracellular proteinsenergy sourceantistress activityneural toxicitysignaling modulatorsmetabolism, chemistry.chemical_classification, Innate immune system, cell plasticity, Chemistry, Cell Biology, Amino acid, Cell biology, nervous system, Cancer cell, Chemical chaperone, Energy source, metabolism, psychological phenomena and processes, Developmental Biology |
| الوصف: | Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer. |
| اللغة: | English |
| تدمد: | 2296-634X |
| DOI: | 10.3389/fcell.2021.728576 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6bce68264226bc446661a85694d05bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8b6bce68264226bc446661a85694d05b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296634X |
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| DOI: | 10.3389/fcell.2021.728576 |