المؤلفون: Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: praliciguat, cGMP (cyclic GMP), nitric oxide, metabolic disease, thermoneutrality, obesity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2022.852080/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/276425e92d2143c0a1202416a49b9492Test

المؤلفون: Ataei Ataabadi, Ehsan, Golshiri, Keivan, Juttner, Annika, Krenning, Guido, Danser, A. H. Jan, Roks, Anton J. M.

المصدر: Ataei Ataabadi , E , Golshiri , K , Juttner , A , Krenning , G , Danser , A H J & Roks , A J M 2020 , ' Nitric Oxide-cGMP Signaling in Hypertension : Current and Future Options for Pharmacotherapy ' , Hypertension , vol. 76 , no. 4 , pp. 1055-1068 . https://doi.org/10.1161/HYPERTENSIONAHA.120.15856Test

مصطلحات موضوعية: hypertension, mitochondria, nitric oxide, oxidoreductase, soluble guanylyl cyclase, SOLUBLE GUANYLATE-CYCLASE, KINASE G I, ACETYLCHOLINE-INDUCED HYPOTENSION, ELECTRONIC CIGARETTE-SMOKING, REACTIVE OXYGEN, BLOOD-PRESSURE, ENDOTHELIAL DYSFUNCTION, STIMULATOR PRALICIGUAT, HEART-FAILURE, ORGAN DAMAGE

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/20e6ea62-9652-4d54-97e4-a594264af4ebTest

الإتاحة: https://doi.org/10.1161/HYPERTENSIONAHA.120.15856Test
https://hdl.handle.net/11370/20e6ea62-9652-4d54-97e4-a594264af4ebTest
https://research.rug.nl/en/publications/20e6ea62-9652-4d54-97e4-a594264af4ebTest
https://pure.rug.nl/ws/files/168960551/HYPERTENSIONAHA.120.15856_1_.pdfTest

المصدر: Hypertension. 76(4):1055-1068

مصطلحات موضوعية: hypertension, ACETYLCHOLINE-INDUCED HYPOTENSION, ELECTRONIC CIGARETTE-SMOKING, soluble guanylyl cyclase, BLOOD-PRESSURE, KINASE G I, ORGAN DAMAGE, mitochondria, nitric oxide, ENDOTHELIAL DYSFUNCTION, SOLUBLE GUANYLATE-CYCLASE, HEART-FAILURE, REACTIVE OXYGEN, STIMULATOR PRALICIGUAT, oxidoreductase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dris___01423::390e45cebb0591100cfdae6428d71ddaTest
https://research.rug.nl/en/publications/20e6ea62-9652-4d54-97e4-a594264af4ebTest

المؤلفون: Annika Jüttner, Guido Krenning, Keivan Golshiri, A.H. Jan Danser, Anton J.M. Roks, Ehsan Ataei Ataabadi

المساهمون: Internal Medicine

المصدر: Hypertension, 76(4), 1055-1068. Lippincott Williams & Wilkins

مصطلحات موضوعية: 0301 basic medicine, Drug, ACETYLCHOLINE-INDUCED HYPOTENSION, media_common.quotation_subject, ELECTRONIC CIGARETTE-SMOKING, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, Pharmacology, Nitric Oxide, Nitric oxide, ORGAN DAMAGE, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacotherapy, Soluble Guanylyl Cyclase, Guanosine monophosphate, Internal Medicine, medicine, SOLUBLE GUANYLATE-CYCLASE, Humans, Endothelial dysfunction, oxidoreductase, Cyclic GMP, Antihypertensive Agents, media_common, business.industry, Phosphodiesterase, medicine.disease, KINASE G I, mitochondria, 030104 developmental biology, chemistry, ENDOTHELIAL DYSFUNCTION, Hypertension, HEART-FAILURE, REACTIVE OXYGEN, STIMULATOR PRALICIGUAT, Soluble guanylyl cyclase, business, cGMP-dependent protein kinase, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4886961b192fa43b4be75f0272de5ee3Test
https://doi.org/10.1161/hypertensionaha.120.15856Test

المؤلفون: Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, praliciguat, cGMP (cyclic GMP), nitric oxide, metabolic disease, thermoneutrality, obesity, soluble guanylate cyclase (sGC)

العلاقة: https://figshare.com/articles/figure/Image1_Beneficial_Metabolic_Effects_of_Praliciguat_a_Soluble_Guanylate_Cyclase_Stimulator_in_a_Mouse_Diet-Induced_Obesity_Model_TIF/19304636Test

الإتاحة: https://doi.org/10.3389/fphar.2022.852080.s001Test
https://figshare.com/articles/figure/Image1_Beneficial_Metabolic_Effects_of_Praliciguat_a_Soluble_Guanylate_Cyclase_Stimulator_in_a_Mouse_Diet-Induced_Obesity_Model_TIF/19304636Test

المؤلفون: Guang Liu, Katherine C. Hall, Sarah Jacobson, Mark G. Currie, Renee Sarno, Sylvie G. Bernier, Victoria Catanzano, Ping Y. Zhang, Jaime L. Masferrer

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: 0301 basic medicine, soluble guanylate cyclase, praliciguat, Anti-Inflammatory Agents, Enzyme Activators, Inflammation, Nitric Oxide, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Soluble Guanylyl Cyclase, Fibrosis, Non-alcoholic Fatty Liver Disease, medicine, Hepatic Stellate Cells, Animals, Humans, Cells, Cultured, Pharmacology, Multidisciplinary, business.industry, AMPK, Biological Sciences, medicine.disease, NASH fibrosis, Coculture Techniques, 030104 developmental biology, Pyrimidines, chemistry, 030220 oncology & carcinogenesis, Hepatic stellate cell, Cancer research, Pyrazoles, Steatosis, medicine.symptom, Signal transduction, business, Myofibroblast, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c65ebd93360b967319371168329084Test
http://europepmc.org/articles/PMC6561202Test

المؤلفون: Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude

المصدر: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)

مصطلحات موضوعية: Male, medicine.medical_specialty, sGC, Metabolite, praliciguat, Glucuronidation, Adipose tissue, RM1-950, 030226 pharmacology & pharmacy, Excretion, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Soluble Guanylyl Cyclase, Pharmacokinetics, Oral administration, nitric oxide, Internal medicine, QWBA, medicine, Animals, Bile, Rats, Long-Evans, Tissue Distribution, General Pharmacology, Toxicology and Pharmaceutics, Original Articles, Bioavailability, cGMP, Endocrinology, Pyrimidines, Neurology, chemistry, 030220 oncology & carcinogenesis, Pyrazoles, Original Article, excretion, Therapeutics. Pharmacology, absorption, metabolism, pharmacokinetics, Drug metabolism, mass balance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4Test
http://europepmc.org/articles/PMC7171252Test

المؤلفون: Andreas Friebe, Peter Sandner, Achim Schmidtko

المصدر: Naunyn-Schmiedeberg's Archives of Pharmacology

مصطلحات موضوعية: Review, sGC stimulators, Nitric oxide, chemistry.chemical_compound, Vericiguat, Animals, Humans, Natriuretic peptides, Receptor, Cyclic guanosine monophosphate, Cyclic GMP, Pharmacology, Riociguat, Chemistry, Effector, Phosphodiesterase, Guanylyl cyclases, General Medicine, Cell biology, cGMP, Crosstalk (biology), sGC activators, Phosphodiesterases, Second messenger system, Soluble guanylyl cyclase, Signal Transduction, Praliciguat

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a6c356bd419fd8073f8b52fc2500bTest
https://pubmed.ncbi.nlm.nih.gov/31853617Test

المصدر: A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Praliciguat ([14C]-IW-1973) Following a Single Oral Dose in Healthy Male Subjects

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03818295Test

المصدر: An Open-label, 2-Period, Fixed-sequence, Phase 1 Study in Healthy Volunteers to Evaluate the Effect of Itraconazole, a Potent CYP3A Inhibitor, on the Pharmacokinetics of IW-1973

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03499106Test