دورية أكاديمية
Clinically Approved Ferric Maltol: A Potent Nanozyme with Added Effect for High-Efficient Catalytic Disinfection
| العنوان: | Clinically Approved Ferric Maltol: A Potent Nanozyme with Added Effect for High-Efficient Catalytic Disinfection |
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| المؤلفون: | Zehui Su, Ting Du, Jianxing Feng, Jianlong Wang, Wentao Zhang |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Biotechnology, Infectious Diseases, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, natural horseradish peroxidase, limited function beyond, ideal therapeutic outcome, facile scalable method, exhibits excellent peroxidase, current antibiotic therapy, commonly reported fe, unknown clinical safety, resistant staphylococcus aureus, desired nanozyme provides, added effects inherited, resistant bacteria, potent nanozyme, clinical application, added effect, wound disinfection, timely alternative, promising candidate, ferric maltol, contained maltol, based nanozymes, 100 %) |
| الوصف: | Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Clinically_Approved_Ferric_Maltol_A_Potent_Nanozyme_with_Added_Effect_for_High-Efficient_Catalytic_Disinfection/25282229Test |
| DOI: | 10.1021/acsami.3c17758.s001 |
| الإتاحة: | https://doi.org/10.1021/acsami.3c17758.s001Test https://figshare.com/articles/journal_contribution/Clinically_Approved_Ferric_Maltol_A_Potent_Nanozyme_with_Added_Effect_for_High-Efficient_Catalytic_Disinfection/25282229Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.4522A249 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsami.3c17758.s001 |
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