Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity
| العنوان: | Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity |
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| المؤلفون: | Naying He, Fuhua Yan, Weiqing Wang, Yafeng Zhan, Guang Ning, Jie Hong, Zheng Wang, Liuqing Xi, Danjie Li, Tingting Bo, Jiqiu Wang, Xiaoqiang Xu, Juan Shi, Peiwen Liang, Wanyu Li, Yufei Chen, Ruixin Liu, Weiqiong Gu |
| المصدر: | The Journal of Clinical Endocrinology and Metabolism |
| بيانات النشر: | The Endocrine Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Physiology, Gut flora, postprandial aGLP-1, Biochemistry, Cohort Studies, Eating, Endocrinology, Glucagon-Like Peptide 1, Weight loss, metagenomic sequencing, Surveys and Questionnaires, Cerebral Cortex, biology, fMRI, Motor Cortex, Putamen, Brain, Clostridia, Magnetic Resonance Imaging, Ghrelin, Treatment Outcome, Postprandial, Female, medicine.symptom, AcademicSubjects/MED00250, Adult, medicine.medical_specialty, Sleeve gastrectomy, vertical sleeve gastrectomy, Context (language use), Gastrointestinal Hormones, Young Adult, Gastrectomy, Internal medicine, medicine, Humans, Obesity, Online Only Articles, Clinical Research Articles, business.industry, Body Weight, Biochemistry (medical), Repeated measures design, eating habits, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, business |
| الوصف: | Context Vertical sleeve gastrectomy (VSG) is becoming a prioritized surgical intervention for obese individuals; however, the brain circuits that mediate its effective control of food intake and predict surgical outcome remain largely unclear. Objective We investigated VSG-correlated alterations of the gut-brain axis. Methods In this observational cohort study, 80 patients with obesity were screened. A total of 36 patients together with 26 normal-weight subjects were enrolled and evaluated using the 21-item Three-Factor Eating Questionnaire (TFEQ), MRI scanning, plasma intestinal hormone analysis, and fecal sample sequencing. Thirty-two patients underwent VSG treatment and 19 subjects completed an average of 4-month follow-up evaluation. Data-driven regional homogeneity (ReHo) coupled with seed-based connectivity analysis were used to quantify VSG-related brain activity. Longitudinal alterations of body weight, eating behavior, brain activity, gastrointestinal hormones, and gut microbiota were detected and subjected to repeated measures correlation analysis. Results VSG induced significant functional changes in the right putamen (PUT.R) and left supplementary motor area, both of which correlated with weight loss and TFEQ scores. Moreover, postprandial levels of active glucagon-like peptide-1 (aGLP-1) and Ghrelin were associated with ReHo of PUT.R; meanwhile, relative abundance of Clostridia increased by VSG was associated with improvements in aGLP-1 secretion, PUT.R activity, and weight loss. Importantly, VSG normalized excessive functional connectivities with PUT.R, among which baseline connectivity between PUT.R and right orbitofrontal cortex was related to postoperative weight loss. Conclusion VSG causes correlated alterations of gut-brain axis, including Clostridia, postprandial aGLP-1, PUT.R activity, and eating habits. Preoperative connectivity of PUT.R may represent a potential predictive marker of surgical outcome in patients with obesity. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44355486e2cab554fb8edb53bfe7d8f5Test https://doi.org/10.1210/clinem/dgab297Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....44355486e2cab554fb8edb53bfe7d8f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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