Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss
| العنوان: | Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss |
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| المؤلفون: | Satoru Takahashi, Yosuke Takei, Saki Tome, Tetsuya Sasaki |
| المصدر: | Experimental Animals |
| بيانات النشر: | Japanese Association for Laboratory Animal Science, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, polyinosinic-polycytidylic acid [poly:(IC)], Original, Receptors, Retinoic Acid, Retinoic acid, Mice, Transgenic, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Immune system, Downregulation and upregulation, RAR-related orphan receptor gamma, Pregnancy, Internal medicine, medicine, Animals, Orphan receptor, retinoic acid-related orphan receptor gamma-t (RORγt), maternal immune activation, General Veterinary, Cell growth, Interleukin-17, Abortion, Induced, General Medicine, abortion, Mice, Inbred C57BL, IL-17, 030104 developmental biology, Endocrinology, Poly I-C, chemistry, Polyinosinic:polycytidylic acid, Th17 Cells, Animal Science and Zoology, Female, Interleukin 17, 030217 neurology & neurosurgery |
| الوصف: | T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid receptor-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum IL-17A and decreased E-cadherin expression in cell-cell junctions of placental tissues. Abortion after the administration of a viral-mimicking synthetic double-stranded RNA polyinosinic-polycytidylic acid was more frequent in RORγt Tg mice than wild-type mice. These results suggest that excessive Th17 cell activity alters immune responsiveness and increases the rate of abortion during gestation. |
| اللغة: | English |
| تدمد: | 1881-7122 1341-1357 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b9d68fa0fb4715646e7642bef8ee4aTest http://europepmc.org/articles/PMC6842800Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54b9d68fa0fb4715646e7642bef8ee4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817122 13411357 |
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