دورية أكاديمية
Polyanhydride Microcapsules Exhibiting a Sharp pH Transition at Physiological Conditions for Instantaneous Triggered Release
| العنوان: | Polyanhydride Microcapsules Exhibiting a Sharp pH Transition at Physiological Conditions for Instantaneous Triggered Release |
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| المؤلفون: | Viktor Eriksson, Leyla Beckerman, Erik Aerts, Markus Andersson Trojer, Lars Evenäs |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Ecology, Inorganic Chemistry, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, quartz crystal microbalance, diffusion coefficients fitted, responsive microcapsules pose, varying ph values, sharp ph transition, controlled triggered release, achieve controlled release, polyanhydride microcapsules exhibiting, microcapsules presented, polyanhydride poly, release measurements, spectrophotometric detection, physiological conditions, mild conditions, mass changes, external stimulus, dissipation monitoring, degradation products, degradation kinetics, correlate excellently, 9 allowed |
| الوصف: | Stimulus-responsive microcapsules pose an opportunity to achieve controlled release of the entire load instantaneously upon exposure to an external stimulus. Core–shell microcapsules based on the polyanhydride poly(bis(2-carboxyphenyl)adipate) as a shell were formulated in this work to encapsulate the model active substance pyrene and enable a pH-controlled triggered release. A remarkably narrow triggering pH interval was found where a change in pH from 6.4 to 6.9 allowed for release of the entire core content within seconds. The degradation kinetics of the shell were measured by both spectrophotometric detection of degradation products and mass changes by quartz crystal microbalance with dissipation monitoring and were found to correlate excellently with diffusion coefficients fitted to release measurements at varying pH values. The microcapsules presented in this work allow for an almost instantaneous triggered release even under mild conditions, thanks to the designed core–shell morphology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Polyanhydride_Microcapsules_Exhibiting_a_Sharp_pH_Transition_at_Physiological_Conditions_for_Instantaneous_Triggered_Release/24584975Test |
| DOI: | 10.1021/acs.langmuir.3c02708.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.langmuir.3c02708.s001Test https://figshare.com/articles/journal_contribution/Polyanhydride_Microcapsules_Exhibiting_a_Sharp_pH_Transition_at_Physiological_Conditions_for_Instantaneous_Triggered_Release/24584975Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.A3AF9116 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.langmuir.3c02708.s001 |
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