دورية أكاديمية
Systemic atherosclerotic plaque vulnerability in patients with Coronary Artery Disease with a single Whole Body [FDG]PET-CT scan.
| العنوان: | Systemic atherosclerotic plaque vulnerability in patients with Coronary Artery Disease with a single Whole Body [FDG]PET-CT scan. |
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| المؤلفون: | Patricia Sanchez Roa, John Rees, Lee Bartley, Christopher Marshall |
| المصدر: | Asia Oceania Journal of Nuclear Medicine and Biology, Vol 8, Iss 1, Pp 18-26 (2020) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Biology (General) |
| مصطلحات موضوعية: | pet, plaque inflammation, plaque calcifications, atherosclerosis, coronary artery disease, Medical physics. Medical radiology. Nuclear medicine, R895-920, Biology (General), QH301-705.5 |
| الوصف: | Objective(s): Cardiovascular disease is a leading cause of morbimortality with over half cardiovascular events occurring in the asymptomatic population by traditional risk stratification. This preliminary study aimed to evaluate systemic plaque vulnerability in patients with prior Coronary Artery Disease (CAD) with a single Whole Body [FDG] PET-CT scan in terms of plaque inflammation and calcifications. Methods: Twenty-two patients referred for oncological evaluation and with prior history of advanced CAD or age and gender matched controls without cardiovascular disease, underwent a Whole Body PET-CT scan 90 min after injection of 18F-FDG. A total of 975 transaxial PET images were retrospectively analysed to assess plaque inflammation using a standardized method of analysis with averaged Target-to-Background Ratios (TBRs) at different levels, in the thoracic and abdominal aorta, carotids, LAD, common iliac and femoral arteries, and were correlated with calcium scores from the CT images. Results: TBRs from the thoracic aorta were higher in male patients than controls (1.49±0.11, p descending > aortic arch), and were also higher in the carotids in female patients (1.43±0.07) versus controls (pConclusion: Patients with advanced CAD are at risk for vulnerable inflamed atheromas in other territories such as the thoracic aorta and carotid arteries, underpinning the systemic nature of the atherosclerotic disease. Coexistence with calcifications is rare, suggesting a different functional status of the plaques and different stages of the disease. Evaluation of subclinical systemic plaque vulnerability in CAD with a Whole Body [FDG] PET-CT scan is feasible and a potentially useful biomarker to assess subclinical vascular risk for risk stratification and treatment optimization, but further studies are needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2322-5718 2322-5726 |
| العلاقة: | http://aojnmb.mums.ac.ir/article_14015_35f08db1d431a3df3e1393b876c0bb97.pdfTest; https://doaj.org/toc/2322-5718Test; https://doaj.org/toc/2322-5726Test |
| DOI: | 10.22038/aojnmb.2019.40696.1273 |
| الوصول الحر: | https://doaj.org/article/9f61dffc36924dfebb9eff867950a1ceTest |
| رقم الانضمام: | edsdoj.9f61dffc36924dfebb9eff867950a1ce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23225718 23225726 |
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| DOI: | 10.22038/aojnmb.2019.40696.1273 |