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1دورية أكاديمية
المؤلفون: Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong, Qiyuan Li
المصدر: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
مصطلحات موضوعية: Gastric cancer, Circular RNA 0001789, MicroRNA-140-3p, p21 activated kinase 2, Epithelial-mesenchymal transition, Medicine
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1479-5876Test
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2رسالة جامعية
المؤلفون: Vendrell Arasa, Alexandre
المساهمون: University/Department: Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
مرشدي الرسالة: Posas Garriga, Francesc
المصدر: TDX (Tesis Doctorals en Xarxa)
مصطلحات موضوعية: STRE: stress response element, TOR: target of rapamycin, SMAC: second mitochondria-derived activator of cas, SAPK: stress activated protein kinase, SCF (complex): Skp1-Cdc53-F-box protein complex, ROS: reactive oxygen species, RING (domain): really interesting new gene domain, RENT (complex): regulator of nucleolar silencing a, PCD: programmed cell death, rDNA: risbosomal DNA, PAK: p21 activated kinase, NAM: nicotinamide, OD: optical density, MEF2C: myocyte enhancer factor 2C, NAD+: nicotinamide adenine dinucleotide, MAPK: mitogen activated protein kinase, SRF from homo sapiens, agamous fromaArabidopsis thaliana, deficiens from the snapdragon antirrhinum majus, saccharomyces cerevisiae, MADS (box): box found in MCM1 from the budding yea, IAP: inhibitor of apoptosis proteins, HECT (domain): homologous to the E6-AP carboxyl te, HOG: high osmolarity glycerol, FACS: fluorescent-activated cell sorting, ERC: extrachromosomal rDNA circles, DUBs: deubiquitinases, CR: caloric restriction, DNA: desoxirribobucleic acid, CDK: cyclin dependent kinase, cdc (mutant): cell-division-cycle defective mutant, bZIP (domain): basic leucine zipper domain, ATP: adenosine triphosphate, as (mutant or allele): analogue-ATP sensitive muta, AMP: adenosine monophosphate, APC/C: anaphase promoting complex/cyclosome, AIF: apoptosis-inducing factor, TUNEL: marcatge d'extrems terminals amb la deoxinu, TOR: Diana de la rapamicina, STRE element de resposta a l'estrés, SCF (complexe): complexe de proteïnes Skp1-Cdc53-F, SMAC: segon activador de caspasses derivat de la m, SAPK: proteïna kinassa activada per stress, RING (domini): domini d'un nou gen realment intere, ROS: especies reactives de l'oygen, RENT (complexe): regulador del silenciament nucleo, rDNA: DNA risbosomal, PCD: mort cel·lular programada, PAK: kinassa activada per p21, OD: densitat òptica, NAM: nicotinàmida, NAD+: nicotinàmida adenina dinucleòtid, MAPK: proteïna kinassa activada per mitògenics, MEF2C: factor 2C activador del miócits, i SRF d'Homo sapiens, del rèptil Antirrhinum majus, AGAMOUS d'Arabidopsis thaliana, DEFICIENS, Saccharomyces cerevisiae, MADS (caixa): caixa trobada a MCM1del llevat, TUNEL: terminal deoxynucleotidyl transferase dUTP, IAP: inhibidor de proteins d'apoptosi, HOG: Osmolaritat elevada de glicerol, HECT (domini): domini homoòleg al domini E6-AP car, FACS: selecció de cèl·lues activada per fluorescèn, ERC: cercle d'rDNA extracromosòmic, DUB: deubiquitinassa, DNA: Àcid desoxirriblonucleic, CR: restricció calòrica, CDK: kinassa dependent de ciclines, cdc (mutant): mutant defectiu en divisió cel·lular, bZIP (domini): bomini en cremallera bàsic de leuci, ATP: trifosfat d'adenosina, as (mutant o al·lel): mutant sensible a l'anàleg d, APC/C: complexe promotor de l'anafase/ciclosoma, AMP: monofosfat d'adenosina, AIF: factor inductor d'apoptosi
وصف الملف: application/pdf
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3دورية أكاديمية
المصدر: Cancers; Volume 15; Issue 2; Pages: 551
مصطلحات موضوعية: p21 Activated Kinase, liver cancer, hepatitis, liver fibrosis, hepatic ischemia-reperfusion injury, small molecular inhibitors
وصف الملف: application/pdf
العلاقة: Cancer Therapy; https://dx.doi.org/10.3390/cancers15020551Test
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4رسالة جامعية
المؤلفون: Hawley, Eric Thomas
مرشدي الرسالة: Clapp, D. Wade, Goebl, Mark G., Harrington, Maureen A., Mirmira, Raghu G.
مصطلحات موضوعية: Neurofibromatosis Type 2, NF-kB Signaling, P21 Activated Kinase, Schwannoma
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5دورية أكاديمية
المؤلفون: Acosta, M.I, Urbach, S, Doye, A, Ng, Y.-W, Boudeau, J, Mettouchi, A, Debant, A, Manser, E, Visvikis, O, Lemichez, E
المساهمون: DEPT OF PHARMACOLOGY
المصدر: Unpaywall 20201031
مصطلحات موضوعية: bacterial toxin, cytotoxic necrotizing factor 1, Escherichia coli protein, HACE1 protein, human, p21 activated kinase, Rac1 protein, serine, ubiquitin protein ligase, vasculotropin A, cell line, chemistry, metabolism, phosphorylation, protein multimerization, proteomics, ubiquitination, umbilical vein endothelial cell, Bacterial Toxins, Escherichia coli Proteins, Human Umbilical Vein Endothelial Cells, Humans, p21-Activated Kinases, rac1 GTP-Binding Protein, Ubiquitin-Protein Ligases, Vascular Endothelial Growth Factor A
العلاقة: Acosta, M.I, Urbach, S, Doye, A, Ng, Y.-W, Boudeau, J, Mettouchi, A, Debant, A, Manser, E, Visvikis, O, Lemichez, E (2018). Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination. Scientific Reports 8 (1) : 1410. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-19471-2Test; https://scholarbank.nus.edu.sg/handle/10635/178469Test
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6دورية أكاديمية
المؤلفون: Alli-Shaik, A, Wee, S, Lim, L.H.K, Gunaratne, J
المساهمون: ANATOMY, PHYSIOLOGY
المصدر: Unpaywall 20201031
مصطلحات موضوعية: calcium calmodulin dependent protein kinase II, I kappa B kinase beta, lipocortin 1, mitogen activated protein kinase, p21 activated kinase, annexin A1, mouse, phosphoprotein, proteome, animal cell, Article, breast epithelium cell, cell adhesion, controlled study, down regulation, focal adhesion, hippo signaling, isotope labeling, mass spectrometry, microtubule assembly, nonhuman, phosphoproteomics, protein phosphorylation, protein processing, signal transduction, stress fiber, Wnt signaling, animal, biology, cluster analysis
العلاقة: Alli-Shaik, A, Wee, S, Lim, L.H.K, Gunaratne, J (2017). Phosphoproteomics reveals network rewiring to a pro-adhesion state in annexin-1-deficient mammary epithelial cells. Breast Cancer Research 19 (1) : 132. ScholarBank@NUS Repository. https://doi.org/10.1186/s13058-017-0924-4Test; https://scholarbank.nus.edu.sg/handle/10635/183471Test
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7
المؤلفون: Venu Akkanapally, Ganesh Krishnamurthy, Archana B, Sowmiya Murugan, Veena Kumari Vuttaradhi, D Prathiba, Dymova Mayya Alexandrovna, Rahul Kanumuri, Lawrence D'Cruze, Ganesh Venkatraman, Rayala Suresh Kumar
المصدر: Cancer Investigation. 39:98-113
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, Young Adult, 03 medical and health sciences, 0302 clinical medicine, PAK1, Cell Line, Tumor, Glioma, Humans, Medicine, Proliferation Marker, Cell Proliferation, Brain Neoplasms, business.industry, Cell growth, General Medicine, Middle Aged, medicine.disease, Phenotype, 030104 developmental biology, p21-Activated Kinases, Oncology, 030220 oncology & carcinogenesis, P21 Activated Kinase 1, Cancer research, Immunohistochemistry, Female, business, Clinical evaluation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fff7db336576c387235aab93943de97Test
https://doi.org/10.1080/07357907.2020.1858097Test -
8دورية أكاديمية
المؤلفون: Selamat W., Tay P.-L.F., Baskaran Y., Manser E.
المساهمون: DEPT OF PHARMACOLOGY
المصدر: Unpaywall 20191101
مصطلحات موضوعية: beta catenin, p21 activated kinase 4, protein Cdc42, protein serine threonine kinase inhibitor, serine, CTNNB1 protein, human, p21 activated kinase, PAK4 protein, PF 3758309, protein kinase inhibitor, pyrazole derivative, pyrrole derivative, animal cell, Article, cell junction, cell migration, cell polarity, centrosome, complex formation, focal adhesion, human cell, MCF 7 cell line, monolayer culture, nonhuman, protein assembly, protein depletion, protein localization, protein phosphorylation, U2OS cell line
العلاقة: Selamat W., Tay P.-L.F., Baskaran Y., Manser E. (2015). The Cdc42 effector kinase PAK4 localizes to cell-cell junctions and contributes to establishing cell polarity. PLoS ONE 10 (6) : e0129634. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0129634Test; https://scholarbank.nus.edu.sg/handle/10635/161506Test
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9
المؤلفون: Shahinozzaman, Shinkichi Tawata, Diana N. Obanda
المصدر: Phytotherapy Research. 35:207-222
مصطلحات موضوعية: Longevity, Anti-Inflammatory Agents, Antineoplastic Agents, Biology, Pacific Islands, Antioxidants, Propolis, Macaranga tanarius, 03 medical and health sciences, 0302 clinical medicine, Anti-Infective Agents, Animals, Humans, Hypoglycemic Agents, Mode of action, Macaranga, Flavonoids, Prenylation, Pharmacology, 0303 health sciences, Molecular Structure, Traditional medicine, 030302 biochemistry & molecular biology, Euphorbiaceae, Bees, biology.organism_classification, Antimicrobial, p21-Activated Kinases, 030220 oncology & carcinogenesis, P21 Activated Kinase 1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc111e6a9abad5d7e898b970aac6d02Test
https://doi.org/10.1002/ptr.6819Test -
10
المؤلفون: Katlin B. Massirer, Lewis E. Pennicott, Fiona Scott, Jonathan M. Elkins, Simon E. Ward, Tristan Reuillon, A.M. Fala
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Models, Molecular, HATU, hexafluorophosphate azabenzotriazole tetramethyl uronium, PARP, poly(ADP-ribose) polymerase, Chemical tool, Clinical Biochemistry, Pharmaceutical Science, IC50, half maximal inhibitory concentration, Chemical probe, PRK, protein kinase C-related kinase, DMSO, dimethyl sulfoxide, Crystallography, X-Ray, PRO2, glutamate 5-kinase Pro2, EGTA, egtazic acid, Benzimidazole, 01 natural sciences, Biochemistry, GST, glutathione S-transferase, CDI, 1,1′-carbonyldiimidazole, AGC, protein kinase A/G/C families, DNA, deoxyribonucleic acid, Neoplasms, CLK, CDC2-like kinase, DMF, N,N-dimethyl-formamide, Drug Discovery, PDB, protein databank, Kinome, Ki, inhibitor constant, Protein Kinase C, Cancer, ChEMBL, European Molecular Biology Laboratory Chemical database, Molecular Structure, Kinase, Chemistry, PRK2, KD, dissociation constant, PAK2, p21 activated kinase 2, DCM, dichloromethane, SFM, scanning force microscopy, Agc kinase, Molecular Medicine, THF, tetrahydrofuran, EtOH, ethanol, SDS, sodium dodecyl sulfate, ATP, adenosine triphosphate, TCEP, tris(2-carboxyethyl)phosphine, Antineoplastic Agents, Kinases, Heart failure, STK, serine/threonine kinase, Article, Structure-Activity Relationship, Protein kinase N2, Drug Development, TR-FRET, time resolved fluorescence resonance energy transfer, AcOH, acetic acid, PKC, protein kinase C, DIPEA, N,N-diisopropylethylamine, medicine, Humans, NMR, nuclear magnetic resonance, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, PAGE, polyacrylamide gel electrophoresis, ComputingMethodologies_COMPUTERGRAPHICS, PKN2, Inflammation, Dose-Response Relationship, Drug, EDTA, ethylenediaminetetraacetic acid, 010405 organic chemistry, Organic Chemistry, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, AGC kinase, medicine.disease, SAR, structure activity relationship, 0104 chemical sciences, Abl, Abelson murine leukemia viral oncogene, 010404 medicinal & biomolecular chemistry, CV, column volumes, Benzimidazoles, MeOH, methanol, PKN, protein kinase N
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1561d0a57fd94895c128a26cfe5805Test
https://doi.org/10.1016/j.bmcl.2020.127040Test
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