Boron-Mediated Regioselective Aromatic C−H Functionalization via an Aryl BF 2 Complex
| العنوان: | Boron-Mediated Regioselective Aromatic C−H Functionalization via an Aryl BF 2 Complex |
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| المؤلفون: | Shinde, Ganesh H., Sundén, Henrik, 1978 |
| المصدر: | Chemistry - A European Journal. 29(1016) |
| مصطلحات موضوعية: | BBr 3, aryl-aldehydes, N-heterocycles, Selectfluor, regioselective, ortho C−H halogenation |
| الوصف: | An efficient regioselective functionalization of 2-aryl-heteroarenes and aryl aldehydes via an azaaryl BF2 complex has been developed. Mechanistically the reaction comprises fluoride to bromide ligand exchange on an aryl boron species and consecutive C−B bond cleavage to deliver a broad range of functionalized products. The reaction is high yielding, has a broad substrate scope where several different heteroarenes can be functionalized with chloro, bromo, iodo, hydroxyl, amine and BF2 in a highly regioselective fashion. The method can be applied for late-stage functionalization or for rapid skeleton remodeling with for instance cross-couplings. |
| وصف الملف: | electronic |
| الوصول الحر: | https://research.chalmers.se/publication/533972Test https://research.chalmers.se/publication/533972/file/533972_Fulltext.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 15213765 09476539 |
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| DOI: | 10.1002/chem.202203505 |