دورية أكاديمية
Detection of a Parkinson's Disease-Specific MicroRNA Signature in Nasal and Oral Swabs.
| العنوان: | Detection of a Parkinson's Disease-Specific MicroRNA Signature in Nasal and Oral Swabs. |
|---|---|
| المؤلفون: | Schließer, Patricia, Struebing, Felix L, Northoff, Bernd H, Kurz, Anna, Rémi, Jan, Holdt, Lesca, Höglinger, Günter U, Herms, Jochen, Koeglsperger, Thomas |
| المصدر: | Movement disorders 38(9), 1706 - 1715 (2023). doi:10.1002/mds.29515 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Humans, Parkinson Disease: diagnosis, Parkinson Disease: genetics, Parkinson Disease: complications, MicroRNAs, Synucleinopathies, REM Sleep Behavior Disorder: diagnosis, Biomarkers, Lewy body disease, Parkinson's disease, biomarker, microRNA, oral and nasal swab |
| جغرافية الموضوع: | DE |
| الوصف: | Biomaterials from oral and nasal swabs provide, in theory, a potential resource for biomarker development. However, their diagnostic value has not yet been investigated in the context of Parkinson's disease (PD) and associated conditions.We have previously identified a PD-specific microRNA (miRNA) signature in gut biopsies. In this work, we aimed to investigate the expression of miRNAs in routine buccal (oral) and nasal swabs obtained from cases with idiopathic PD and isolated rapid eye movement sleep behavior disorder (iRBD), a prodromal symptom that often precedes α-synucleinopathies. We aimed to address their value as a diagnostic biomarker for PD and their mechanistic contribution to PD onset and progression.Healthy control cases (n = 28), cases with PD (n = 29), and cases with iRBD (n = 8) were prospectively recruited to undergo routine buccal and nasal swabs. Total RNA was extracted from the swab material, and the expression of a predefined set of miRNAs was quantified by quantitative real-time polymerase chain reaction.Statistical analysis revealed a significantly increased expression of hsa-miR-1260a in cases who had PD. Interestingly, hsa-miR-1260a expression levels correlated with diseases severity, as well as olfactory function, in the PD and iRBD cohorts. Mechanistically, hsa-miR-1260a segregated to Golgi-associated cellular processes with a potential role in mucosal plasma cells. Predicted hsa-miR-1260a target gene expression was reduced in iRBD and PD groups.Our work demonstrates oral and nasal swabs as a valuable biomarker pool in PD and associated neurodegenerative conditions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/0885-3185; info:eu-repo/semantics/altIdentifier/issn/1531-8257; info:eu-repo/semantics/altIdentifier/pmid/pmid:37382573; https://pub.dzne.de/record/263984Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-00918%22Test |
| الإتاحة: | https://doi.org/10.1002/mds.29515Test https://pub.dzne.de/record/263984Test https://pub.dzne.de/search?p=id:%22DZNE-2023-00918%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D1C4540C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |