التفاصيل البيبلوغرافية
| العنوان: |
Magnetic Resonance Imaging Evaluation of Bone Metastases Treated with Radiotherapy in Palliative Intent: A Multicenter Prospective Study on Clinical and Instrumental Evaluation Assessment Concordance (MARTE Study) |
| المؤلفون: |
Alfonso Reginelli, Vittorio Patanè, Fabrizio Urraro, Anna Russo, Marco De Chiara, Alfredo Clemente, Umberto Atripaldi, Giovanni Balestrucci, Mauro Buono, Emma D’ippolito, Roberta Grassi, Ida D’onofrio, Stefania Napolitano, Teresa Troiani, Ferdinando De Vita, Fortunato Ciardiello, Valerio Nardone, Salvatore Cappabianca |
| المصدر: |
Diagnostics; Volume 13; Issue 14; Pages: 2334 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
magnetic resonance, oncologic, radiotherapy, oncologic diagnostics, bone metastases, lung cancer, breast cancer, prostate cancer, whole-body diffusion weighted imaging, whole body-MRI |
| الوصف: |
Metastasis to bone is a common occurrence among epithelial tumors, with a high incidence rate in the Western world. As a result, bone lesions are a significant burden on the healthcare system, with a high morbidity index. These injuries are often symptomatic and can lead to functional limitations, which in turn cause reduced mobility in patients. Additionally, they can lead to secondary complications such as pathological fractures, spinal cord compression, hypercalcemia, or bone marrow suppression. The treatment of bone metastases requires collaboration between multiple healthcare professionals, including oncologists, orthopedists, neurosurgeons, physiatrists, and radiotherapists. The primary objective of this study is to evaluate the correlation between two methods used to assess local control. Specifically, the study aims to determine if a reduction in the volume of bone lesions corresponds to better symptomatic control in the clinical management of patients, and vice versa. To achieve this objective, the study evaluates morphological criteria by comparing pre- and post-radiotherapy treatment imaging using MRI and RECIST 1.1 criteria. MRI without contrast is the preferred diagnostic imaging method, due to its excellent tolerance by patients, the absence of exposure to ionizing radiation, and the avoidance of paramagnetic contrast media side effects. This imaging modality allows for accurate assessment of bone lesions. One of the secondary objectives of this study is to identify potentially useful parameters that can distinguish patients into two classes: “good” and “poor” responders to treatment, as reported by previous studies in the literature. These parameters can be evaluated from the imaging examinations by analyzing morphological changes and radiomic features on different sequences, such as T1, STIR (short tau inversion recovery), and DWI-MRI (diffusion-weighted). |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Medical Imaging and Theranostics; https://dx.doi.org/10.3390/diagnostics13142334Test |
| DOI: |
10.3390/diagnostics13142334 |
| الإتاحة: |
https://doi.org/10.3390/diagnostics13142334Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A3AF39A7 |
| قاعدة البيانات: |
BASE |
