التفاصيل البيبلوغرافية
| العنوان: |
Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues |
| المؤلفون: |
Silvia Sanz-González, José García-Medina, Vicente Zanón-Moreno, María López-Gálvez, David Galarreta-Mira, Lilianne Duarte, Mar Valero-Velló, Ana Ramírez, J. Arévalo, María Pinazo-Durán, on behalf of the Valencia Study Group on Diabetic Retinopathy (VSDR) Report number 4 |
| المصدر: |
Antioxidants; Volume 9; Issue 11; Pages: 1101 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
type 2 diabetes mellitus, retinopathy, oxidative stress, antioxidants, omega-3 fatty acids, candidate biomarkers, prevention of blindness |
| جغرافية الموضوع: |
agris |
| الوصف: |
Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Health Outcomes of Antioxidants and Oxidative Stress; https://dx.doi.org/10.3390/antiox9111101Test |
| DOI: |
10.3390/antiox9111101 |
| الإتاحة: |
https://doi.org/10.3390/antiox9111101Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.6D22621B |
| قاعدة البيانات: |
BASE |
