Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure
| العنوان: | Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure |
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| المؤلفون: | Natalie Pattison, Sally Humphreys, Timothy S. Walsh, Bronwen Connolly, Philip Hopkins, Nishkantha Arulkumaran, Geraldine O’Gara, Paul Dark |
| المصدر: | Pattison, N, Arulkumaran, N, O'gara, G, Connolly, B, Humphreys, S, Walsh, T, Hopkins, P & Dark, P 2019, ' Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure ', BMJ Open, vol. 9, no. 12, pp. e030815 . https://doi.org/10.1136/bmjopen-2019-030815Test BMJ Open |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Patient Consent, Critical Care, barriers, critical care trials, 03 medical and health sciences, 0302 clinical medicine, Nursing, Intensive care, Health care, access to research, Humans, Medicine, 030212 general & internal medicine, Qualitative Research, Original Research, Clinical Trials as Topic, business.industry, Patient Selection, Resource constraints, Intensive Care, 030208 emergency & critical care medicine, General Medicine, United Kingdom, Clinical trial, Patient recruitment, Intensive Care Units, qualitative synthesis, facilitators, Thematic analysis, business, normalising research, Qualitative research |
| الوصف: | Conducting clinical trials in critical care is integral to improving patient care. Unique practical and ethical considerations exist in this patient population that make patient recruitment challenging, including narrow recruitment timeframes and obtaining patient consent often in time-critical situations. Units currently vary significantly in their ability to recruit according to infrastructure and level of research activity.AimTo identify variability in the research infrastructure of UK intensive care units and their ability to conduct research and recruit patients into clinical trials.DesignWe evaluated factors related to intensive care patient enrolment into clinical trials in the UK. This consisted of a qualitative synthesis carried out with two datasets of in-depth interviews (distinct participants across the two datasets) conducted with 27 intensive care consultants (n=9), research nurses (n=17) and trial coordinators (n=1) from 27 units across the UK. Primary and secondary analyses of two datasets (one dataset had been analysed previously) were undertaken in the thematic analysis.FindingsThe synthesis yielded an overarching core theme of normalising research, characterised by motivations for promoting research and fostering research-active cultures within resource constraints, with six themes under this to explain the factors influencing critical care research capacity: organisational, human, study, practical resources, clinician and patient/family factors. There was a strong sense of integrating research in routine clinical practice, and recommendations are outlined.ConclusionsThe central and transferable tenet of normalising research advocates the importance of developing a culture where research is inclusive alongside clinical practice in routine patient care and is a requisite for all healthcare individuals from organisational to direct patient contact level. |
| وصف الملف: | application/pdf |
| تدمد: | 2044-6055 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436ee3880013ba5043574fd232558e8eTest https://doi.org/10.1136/bmjopen-2019-030815Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....436ee3880013ba5043574fd232558e8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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