المؤلفون: Krysantieva, A. I., Voronina, J. K., Safin, D. A.

المصدر: International Journal of Molecular Sciences

مصطلحات موضوعية: AMBROXOL, COVID-19, CRYSTAL STRUCTURE, MOLECULAR DOCKING, MOLECULAR DYNAMICS, NMR, SARS-COV-2, SYNTHESIS, TETRAHYDROQUINAZOLINE, X-RAY, 2 [6,8 DIBROMO 3 (4 HYDROXYCYCLOHEXYL) 1,2,3,4 TETRAHYDROQUINAZOLIN 2 YL]PHENOL, ALCOHOL, CARBON, CORONAVIRUS PAPAIN-LIKE PROTEASE, CORONAVIRUS PROTEIN, LIGAND, METHANOL, NONSTRUCTURAL PROTEIN 3, SALICYLALDEHYDE, TETRAHYDROQUINAZOLINE DERIVATIVE, UNCLASSIFIED DRUG, PAPAIN, PEPTIDE HYDROLASE, ARTICLE, BINDING AFFINITY, BLOOD BRAIN BARRIER, CHIRALITY, CONTROLLED STUDY, CORONAVIRUS DISEASE 2019, DENSITY FUNCTIONAL THEORY

وصف الملف: application/pdf

العلاقة: Krysantieva, AI, Voronina, JK & Safin, DA 2023, 'A Novel Ambroxol-Derived Tetrahydroquinazoline with a Potency against SARS-CoV-2 Proteins', International Journal of Molecular Sciences, Том. 24, № 5, 4660. https://doi.org/10.3390/ijms24054660Test; Krysantieva, A. I., Voronina, J. K., & Safin, D. A. (2023). A Novel Ambroxol-Derived Tetrahydroquinazoline with a Potency against SARS-CoV-2 Proteins. International Journal of Molecular Sciences, 24(5), [4660]. https://doi.org/10.3390/ijms24054660Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149865474&doi=10.3390%2fijms24054660&partnerID=40&md5=d393beede35287c50cfe9c01a4437c1dTest; https://www.mdpi.com/1422-0067/24/5/4660/pdf?version=1678180496Test; http://elar.urfu.ru/handle/10995/130271Test; 85149865474

الإتاحة: https://doi.org/10.3390/ijms24054660Test
http://elar.urfu.ru/handle/10995/130271Test
https://www.mdpi.com/1422-0067/24/5/4660/pdf?version=1678180496Test

المؤلفون: Jane Yeh, Elizabeth Troisi, Rachy Abraham, Diane Griffin

المصدر: Proceedings, Vol 50, Iss 78, p 78 (2020)

مصطلحات موضوعية: Sindbis virus, NF-κB, IRF7, encephalomyelitis, mice, nonstructural protein 3, General Works

العلاقة: https://www.mdpi.com/2504-3900/50/1/78Test; https://doaj.org/toc/2504-3900Test; https://doaj.org/article/26fc5fdeb67c43f883dc9f90aa31cb0cTest

الإتاحة: https://doi.org/10.3390/proceedings2020050078Test
https://doaj.org/article/26fc5fdeb67c43f883dc9f90aa31cb0cTest

المؤلفون: Bobby Brooke Herrera, Wen-Yang Tsai, Carlos Brites, Estela Luz, Celia Pedroso, Jan Felix Drexler, Wei-Kung Wang, Phyllis J. Kanki

المصدر: mBio, Vol 9, Iss 4 (2018)

مصطلحات موضوعية: Brazil, dengue virus, T cell immunity, Zika virus, nonstructural protein 3, Microbiology, QR1-502

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2150-7511Test

الوصول الحر: https://doaj.org/article/6c10ba21bab8448fafe27a256ff4c24cTest

المؤلفون: Wei-Li Hsu, Yeu Yang Tseng, Abigail Lien, Guan Ru Liao

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1072-1080 (2021)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: PRCV, porcine respiratory coronavirus, viruses, CoV, coronavirus, medicine.disease_cause, Biochemistry, ECoV, equine coronavirus, N protein, 0302 clinical medicine, Structural Biology, Virtual screen, Pandemic, FIPV, feline infectious peritonitis virus, RNP, ribonucleoproteins, Coronavirus, COVID-19, coronavirus disease 2019, 0303 health sciences, BCoV, bovine coronavirus, virus diseases, MERS-CoV, Middle East respiratory syndrome coronavirus, PEDV, Porcine epidemic diarrhea virus, Computer Science Applications, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, HCoVs, human coronaviruses, Severe acute respiratory syndrome coronavirus, nsp3, the nonstructural protein 3, Biotechnology, FECV, feline enteric coronavirus, Coronavirus disease 2019 (COVID-19), TGEV, transmissible gastroenteritis virus, Middle East respiratory syndrome coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV, severe acute respiratory syndrome coronavirus, IBV, infectious bronchitis virus, Biophysics, Article, AMP, UMP, GMP and CMP, ribonucleoside 5′-monophosphates, 03 medical and health sciences, E, envelope protein, medicine, Genetics, NTD, N-terminus RNA-binding domain, IFN, interferon, SP, spike protein, MHV, mouse hepatitis virus, shRNAs, short hairpin RNAs, 030304 developmental biology, SeCoV, swine enteric coronavirus, business.industry, RBD, RNA-binding domain, SARS-CoV-2, Inhibitors, Viral nucleocapsid, CCoV, canine coronavirus, COVID-19, PDCoV, porcine deltacoronavirus, Virology, MP, membrane protein, TCoV, turkey coronavirus, siRNA, small interfering RNA, CTD, C-terminus dimerization domain, Antagonists, business, TP248.13-248.65

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3629fc57d66d1eb6084c8bf060868ebTest
http://www.sciencedirect.com/science/article/pii/S2001037021000362Test

المؤلفون: Phoo, W.W, Li, Y, Zhang, Z, Lee, M.Y, Loh, Y.R, Tan, Y.B, Ng, E.Y, Lescar, J, Kang, C, Luo, D

المساهمون: DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20201031

مصطلحات موضوعية: nonstructural protein 2B, nonstructural protein 3, polyprotein, protease inhibitor BPTI, proteinase, proteinase inhibitor, structural protein, unclassified drug, peptide hydrolase, protein binding, viral protein, amino acid, crystal structure, nuclear magnetic resonance, population outbreak, protein, public health, substrate, viral disease, virus, Article, carboxy terminal sequence, comparative study, controlled study, enzyme active site, enzyme activity, enzyme assay, enzyme inhibition, enzyme structure, molecular recognition

العلاقة: Phoo, W.W, Li, Y, Zhang, Z, Lee, M.Y, Loh, Y.R, Tan, Y.B, Ng, E.Y, Lescar, J, Kang, C, Luo, D (2016). Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nature Communications 7 : 13410. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms13410Test; https://scholarbank.nus.edu.sg/handle/10635/179788Test

الإتاحة: https://doi.org/10.1038/ncomms13410Test
https://scholarbank.nus.edu.sg/handle/10635/179788Test

المؤلفون: Cheri A. Koetzner, Kelley R. Hurst-Hess, Lili Kuo, Paul S. Masters

المصدر: Virology

مصطلحات موضوعية: Nucleocapsid protein, Murine hepatitis virus, Coronavirus RNA-Dependent RNA Polymerase, Viral genomic RNA, Mouse hepatitis virus, viruses, Amino Acid Motifs, Viral RNA synthesis, Intracellular Membranes, Article, Nonstructural protein 3, Cell Line, Coronavirus, Mice, Protein Domains, Virology, Mutation, Animals, Coronavirus Nucleocapsid Proteins, RNA, Viral, Viral Replicase Complex Proteins, Viral Replication Compartments, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94739690db851fc99216a4906a9f153Test
https://pubmed.ncbi.nlm.nih.gov/34933176Test

المؤلفون: Sweeney, Noreena L., Hanson, Alicia M., Mukherjee, Sourav, Ndjomou, Jean, Geiss, Brian J., Steel, J. Jordan, Frankowski, Kevin J., Li, Kelin, Schoenen, Frank J., Frick, David N.

مصطلحات موضوعية: Nonstructural protein 3, ATPase, Motor protein, Direct acting antiviral, Dengue fever, West Nile virus, Yellow fever virus, Positive sense single-strand RNA ((+)ssRNA) virus

وصف الملف: application/pdf

العلاقة: Sweeney, N. L., Hanson, A. M., Mukherjee, S., Ndjomou, J., Geiss, B. J., Steel, J. J., … Frick, D. N. (2015). Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. ACS Infectious Diseases, 1(3), 140–148. http://doi.org/10.1021/id5000458Test; http://hdl.handle.net/1808/23840Test; PMC4444071

الإتاحة: https://doi.org/10.1021/id5000458Test
http://hdl.handle.net/1808/23840Test

المؤلفون: Mark W. Jackwood, Brian J. Jordan, Grace A. Albanese, Deborah A. Hilt, Dong-Hun Lee, I-Hsin N. Cheng

المصدر: Vaccine

مصطلحات موضوعية: 0301 basic medicine, Serotype, Infectious bronchitis virus, Virus Replication, US, United States, Arkansas GA serotype vaccine, 0403 veterinary science, ArkDPI, Arkansas Delmarva Poultry Industry, SPF, specific-pathogen free, CT, cycle threshold, nsp3, nonstructural protein 3, Ark99, Arkansas 99, Attenuated vaccine, Reverse Transcriptase Polymerase Chain Reaction, Vaccination, 04 agricultural and veterinary sciences, SNP, single nucleotide polymorphism, SEM, standard error of mean, Infectious Diseases, Molecular Medicine, Coronavirus Infections, RT-PCR, reverse-transcriptase polymerase chain reaction, 040301 veterinary sciences, CAS, chorioallantoic sac, IBV, infectious bronchitis virus, SARS-CoV, severe acute respiratory syndrome coronavirus, PBS, phosphate-buffered saline, ArkGA, Arkansas Georgia, Biology, EID50, 50% embryo infective dose, Real-Time Polymerase Chain Reaction, Serogroup, Vaccines, Attenuated, Polymorphism, Single Nucleotide, Virus, Article, 03 medical and health sciences, nsp2, nonstructural protein 2, Animals, Tropism, USDA, United States Department of Agriculture, General Veterinary, General Immunology and Microbiology, qRT-PCR, quantitative real-time reverse-transcriptase polymerase chain reaction, Public Health, Environmental and Occupational Health, Embryonated, Virology, 030104 developmental biology, P, passage, Viral replication, Arkansas DPI serotype vaccine, SD, standard deviation, Chickens, MHV, murine hepatitis virus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a19bcbbdb1f2146246a226dd527ac93Test
http://europepmc.org/articles/PMC7115623Test

المؤلفون: C.A. Brosey, Davide Moiani, Leslie S. Warden, Shobanbabu Bommagani, John A. Tainer, Panagiotis Katsonis, Olivier Lichtarge, Todd M. Link, Zamal Ahmed, Darin E. Jones, Andy Arvai, Jerry H. Houl, Albino Bacolla, Lakshitha P.F. Balapiti-Modarage

المصدر: Progress in Biophysics and Molecular Biology

مصطلحات موضوعية: Models, Molecular, Glycoside Hydrolases, poly(ADP-ribose) glycohydrolase, (PARG), 030303 biophysics, Protein domain, SARS-CoV-2 Nsp3 macrodomain, Biophysics, Coronavirus Papain-Like Proteases, Computational biology, Biology, Crystallography, X-Ray, Antiviral Agents, Article, Chemical library, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Protein Domains, In silico screening, microscale thermophoresis, (MST), Catalytic Domain, Drug Discovery, Structure–activity relationship, Humans, evolutionary trace, (ET), Amino Acid Sequence, Enzyme Inhibitors, Molecular Biology, Poly(ADP-ribose) glycohydrolase, Severe Acute Respiratory Syndrome, (SARS), Poly(ADP-Ribose) glycohydrolase (PARG), 0303 health sciences, PARG, Drug discovery, SARS-CoV-2, multiple sequence alignment, (MSA), Active site, nonstructural protein 3, (Nsp3), COVID-19 Drug Treatment, Evolutionary trace (ET), chemistry, PARG inhibitor (PARGi), Xanthines, Proteome, biology.protein, 2-(N-morpholino)ethanesulfonic acid, (MES), poly(ADP-ribose) polymerase, (PARP)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5969135f8e4ac8f12c9f9de86d773513Test
https://pubmed.ncbi.nlm.nih.gov/33636189Test

المؤلفون: Khan, M. I., Baig, M. H., Mondal, Tanmoy, 1981, Alorabi, M., Sharma, T., Dong, J. J., Cho, J. Y.

المصدر: Viruses. 13(11)

مصطلحات موضوعية: Microbiology in the medical area, Mikrobiologi inom det medicinska området, COVID-19, Delta variant, Double mutant, Kappa variant, Molecular dynamics, SARS-CoV-2, Variant, angiotensin converting enzyme 2, bamlanivimab, monoclonal antibody, nonstructural protein 3, receptor binding domain, unclassified drug, viral protein, virus spike protein, Article, binding affinity, binding site, computer simulation, controlled study, crystal structure, gene interaction, gene mutation, genetic analysis, human, hydrogen bond, hydrophobicity, mathematical analysis, molecular docking, molecular interaction, nonhuman, pandemic, principal component analysis, receptor binding, SARS-CoV-2 variant VUI-21APR-01, virus transmission

الوصول الحر: https://gup.ub.gu.se/publication/315487Test