دورية أكاديمية
An Adjuvant Micelle-Based Multifunctional Nanosystem for Tumor Immunotherapy by Remodeling Three Types of Immunosuppressive Cells
| العنوان: | An Adjuvant Micelle-Based Multifunctional Nanosystem for Tumor Immunotherapy by Remodeling Three Types of Immunosuppressive Cells |
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| المؤلفون: | Siyu Meng, Huiping Du, Xiang Li, Xinmin Zheng, Pan Zhao, Zhang Yuan, Shaohui Huang, Yanli Zhao, Liangliang Dai |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Cell Biology, Pharmacology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, responsive size reduction, mediated targeting endocytosis, charge reversal strategy, nanosystem significantly conquers, infiltrating dendritic cells, derived suppressor cells, penetration barrier via, electrostatic adsorption pathways, intricate immune tolerance, evokes immune memory, based multifunctional nanosystem, tams ), tumor, immunosuppressive cells immunotherapy, remodeling three types, based nanosystem, immunosuppressive cells, three types, tolerant cells, via mannose, tidcs ) |
| الوصف: | Immunotherapy is restricted by a complex tumor immunosuppressive microenvironment (TIM) and low drug delivery efficiency. Herein, a multifunctional adjuvant micelle nanosystem (PPD/MPC) integrated with broken barriers and re-education of three classes of immune-tolerant cells is constructed for cancer immunotherapy. The nanosystem significantly conquers the penetration barrier via the weakly acidic tumor microenvironment-responsive size reduction and charge reversal strategy. The detached core micelle MPC could effectively be internalized by tumor-associated macrophages (TAMs), tumor-infiltrating dendritic cells (TIDCs), and myeloid-derived suppressor cells (MDSCs) via mannose-mediated targeting endocytosis and electrostatic adsorption pathways, promoting the re-education of immunosuppressive cells for allowing them to reverse from pro-tumor to antitumor phenotypes by activating TLR4/9 pathways. This process in turn leads to the remodeling of TIM. In vitro and in vivo studies collectively indicate that the adjuvant micelle-based nanosystem not only relieves the intricate immune tolerance and remodels TIM via reprogramming the three types of immunosuppressive cells and regulating the secretion of relevant cytokines/immunity factors but also strengthens immune response and evokes immune memory, consequently suppressing the tumor growth and metastasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/An_Adjuvant_Micelle-Based_Multifunctional_Nanosystem_for_Tumor_Immunotherapy_by_Remodeling_Three_Types_of_Immunosuppressive_Cells/25021322Test |
| DOI: | 10.1021/acsnano.3c08792.s001 |
| الإتاحة: | https://doi.org/10.1021/acsnano.3c08792.s001Test https://figshare.com/articles/journal_contribution/An_Adjuvant_Micelle-Based_Multifunctional_Nanosystem_for_Tumor_Immunotherapy_by_Remodeling_Three_Types_of_Immunosuppressive_Cells/25021322Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.C6FF07B2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsnano.3c08792.s001 |
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