المؤلفون: Mary O’Reilly, Aleksandar Krstic, Luis F. Iglesias-Martinez, Éanna J. Ryan, Bruce Moran, Des Winter, Kieran Sheahan, Ray McDermott, Walter Kolch

المصدر: Journal of Personalized Medicine, Vol 14, Iss 6, p 639 (2024)

مصطلحات موضوعية: early-onset colorectal cancer (EOCRC), colorectal cancer (CRC), focal nodular hyperplasia, RAS mutated cancers, WRN (Werner Syndrome RecQ-like Helicase), Medicine

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4426/14/6/639Test; https://doaj.org/toc/2075-4426Test

الوصول الحر: https://doaj.org/article/a3ef6a494cbc45ac8d1769223a2f6c7aTest

المؤلفون: Ying Liang, Quanlin An, Huaxin Song, Yigang Tang, Shujun Xiao, Jiale Wu, Ni Yan, Biao Yu, Xin Cao, Min Lu

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, similar binding mechanism, potential clinical candidate, potent cellular uptake, poor cellular uptake, frequently mutated protein, acglcas significantly extended, targeting ato trials, targeting arsenical, xenograft tumor, targets pml, sulfur atoms, rationally developed, preclinical studies, oral bioavailability, novel arsenical, normal lines, mutated cancers, miraculous success, mice bearing, mediated pathway, maximally 127

العلاقة: https://figshare.com/articles/journal_contribution/AcGlcAs_A_Novel_P53-Targeting_Arsenical_with_Potent_Cellular_Uptake_and_Cancer_Cell_Selectivity/24781865Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00104.s001Test
https://figshare.com/articles/journal_contribution/AcGlcAs_A_Novel_P53-Targeting_Arsenical_with_Potent_Cellular_Uptake_and_Cancer_Cell_Selectivity/24781865Test

المؤلفون: Antonella Verrienti, Giorgio Grani, Marialuisa Sponziello, Valeria Pecce, Giuseppe Damante, Cosimo Durante, Diego Russo, Sebastiano Filetti

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: RET deletions, RET indels, acquired resistance, medullary thyroid cancer (MTC), RET-mutated cancers, pralsetinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.992636/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/0449b9661b194587b895f881303c1e68Test

المؤلفون: O'Reilly, Mary, Krstic, Aleksandar, Iglesias-Martinez, Luis F, Ryan, Éanna J, Moran, Bruce, Winter, Des, Sheahan, Kieran, McDermott, Ray, Kolch, Walter

المصدر: J Pers Med ; ISSN:2075-4426 ; Volume:14 ; Issue:6

مصطلحات موضوعية: RAS mutated cancers, WRN (Werner Syndrome RecQ-like Helicase), colorectal cancer (CRC), early-onset colorectal cancer (EOCRC), focal nodular hyperplasia

العلاقة: https://doi.org/10.3390/jpm14060639Test; https://pubmed.ncbi.nlm.nih.gov/38929861Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204579Test/

الإتاحة: https://doi.org/10.3390/jpm14060639Test
https://pubmed.ncbi.nlm.nih.gov/38929861Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11204579Test/

المؤلفون: Zijun Chen (286584), Gianluca Destro (6166061), Florian Guibbal (6588116), Chung Ying Chan (11355308), Bart Cornelissen (339544), Véronique Gouverneur (1300443)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Virology, Chemical Sciences not elsewhere classified, successful approach features, report two strategies, poly ­( adp, >- mutated cancers, affords [< sup, ), molar activity (<, 18 , f ]­ rucaparib, [< sup, activity yield, >< sub, vitro <, n <, brca <, mediated radiosynthesis, mediated nucleophilic, inhibitor rucaparib, 30 gbq

العلاقة: https://figshare.com/articles/journal_contribution/Copper-Mediated_Radiosynthesis_of_sup_18_sup_F_Rucaparib/16539848Test

الإتاحة: https://doi.org/10.1021/acs.orglett.1c02770.s001Test

المؤلفون: Carmen Muñoz-Maldonado, Yitzhak Zimmer, Michaela Medová

المصدر: Frontiers in Oncology, Vol 9 (2019)

مصطلحات موضوعية: RAS mutations, RAS profile, RAS-mutated cancers, treatment responses, RAS-related omics, GTP/GDP binding, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fonc.2019.01088/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/bc2c377d2160459aa4a782fa5191af82Test

المصدر: A Phase 2 Study to Evaluate the Efficacy and Safety of Belzutifan (MK-6482, Formerly PT2977) Monotherapy in Participants With Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Advanced Solid Tumors With HIF-2α Related Genetic Alterations

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04924075Test

Other URLs: https://www.merckclinicaltrials.comTest/
https://trialstransparency.merckclinicaltrials.com/Study.aspx?id=6482-015&&kw=6482-015Test